Efficacy of chitosan derivative films versus hydrocolloid dressing on superficial wounds

Abstract

Objectives Chitosan, the N-deacetylated derivative of chitin, has useful biological properties that promote haemostasis, analgesia, wound healing, and scar reduction; chitosan is bacteriostatic, biocompatible, and biodegradable. This study determined the efficacy of chitosan derivative film as a superficial wound dressing. Methods This multicentre randomised controlled trial included 244 patients, of whom 86 were treated with chitosan derivative film and 84 with hydrocolloid. The percentage of epithelisation, as well as patient comfort, clinical signs, and patient convenience in application and removal of the dressings were assessed. Results The primary outcome of this study was the percentage of epithelisation. Except for race ( p = 0.04), there were no significant differences between groups in sex, age, antibiotic usage, or initial wound size ( p > 0.05). There was no significant difference in the mean epithelisation percentage between groups ( p = 0.29). Patients using chitosan derivative film experienced more pain during removal of dressing than those in the hydrocolloid group ( p = 0.007). The chitosan derivative film group showed less exudate ( p = 0.036) and less odour ( p = 0.024) than the control group. Furthermore, there were no significant differences between groups in terms of adherence, ease of removal, wound drainage, erythema, itchiness, pain, and tenderness. No oedema or localised warmth was observed during the study. Conclusion This study concluded that chitosan derivative film is equivalent to hydrocolloid dressing and can be an option in the management of superficial and abrasion wounds. Clinical trial No. NMRR-11-948-10565.

Crab vs. Mushroom: A Review of Crustacean and Fungal Chitin in Wound Treatment

“…Dental surgery clinical trials also found chitosan-based wound treatments to significantly shorten bleeding time and improve wound healing for patients undergoing minor surgery and tooth extractions [167,168]. Clinical trials examining the effect of chitosan on a range of other wounds also exhibited very promising results, with improved cell adherence, hemostasis and re-epithelialization [164,171], less itching and sensitivity [171], less exudate and odor [175], and reductions in wound healing time [170,173], post-hemodialysis puncture site bleeding [173], and rebleeding [174] in diabetic, puncture, superficial, skin graft, and sinus postoperative wounds. Chitosan has also been utilized in clinical trials for treatment of ulcers with notable reductions in exudate, pain on dressing removal, wound area and depth when compared to traditional Vaseline gauze dressings [176,177].…”

“…Human clinical trials utilizing commercially available and custom-made chitin and chitosan wound treatments, resulting in significant improvements in the healing of ear, nasal, oral, and skin wounds, in addition to treatment of ulcers and serious hemorrhages. Data from [162][163][164][165][166][167][168][169][170][171][172][173][174][175][176][177]. Chitosan, unknown [177] These wound treatments have experienced significant success in oral clinical trials where they have been used to treat aphthous stomatitis (mouth ulcers), postoperative and tooth extraction wounds.…”

Recent trends on wound management: New therapeutic choices based on polymeric carriers

“…Moreover, similar data were found in terms of adherence, ease of removal, wound drainage, erythema, itchiness, pain, and tenderness between the groups. Finally, it can be said that both CS derivative film and hydrocolloid dressing is a beneficial solution for superficial and abrasion wounds [49] .…”

Role of different types of nanomaterials against diagnosis, prevention and therapy of COVID-19

“…Chitosan as the second most abundant natural polymer-based nanoparticles with the potential to modify into desired size and shape, are highly demanded to apply in biomedical applications ( Halim et al, 2018 ; Sonaje et al, 2012 ). Chitosan with the linear and partially acetylated (1–4)-2-amino-2-deoxy-d-glucan structure widely employed as drug carriers and also ideal nucleic acid delivery vehicles due to their biocompatibility, biodegradability and non-toxicity properties ( Wang et al, 2011 ).…”