Efficacy of chemical approaches for implant surface decontamination in conjunction with sub‐marginal instrumentation, in the non‐surgical treatment of peri‐implantitis: A systematic review

Abstract

Aim: To answer the following PICOS question: In adult patients with peri-implantitis, what is the efficacy of sub-marginal instrumentation combined with chemical surface decontamination in comparison with sub-marginal instrumentation with or without placebo, in terms of changes in probing depth (PD) and/or bleeding on probing, as reported in prospective randomized controlled trials, nonrandomized controlled trials, or prospective cohort studies, with a minimum of 6-month "follow-up". Materials and Methods: A systematic literature search was performed in PubMed, Web of Science, Embase, Scopus, Ovid Medline, and The Cochrane Library of the Cochrane Collaboration (CENTRAL) for articles published until March 2022. Data addressing the primary and secondary outcomes were extracted.Results: The search gave 2033 results of which 3 fulfilled the inclusion criteria. Two studies investigated the use of anti-microbial photodynamic therapy as adjunct to sub-marginal instrumentation and the third study assessed the adjunctive use of a desiccant material. A meta-analysis was not deemed meaningful because of the large heterogeneity among the studies. All three studies showed favourable results in terms of PD reduction for chemical surface decontamination over control approaches, but were inconsistent or showed no differences for the other outcome variables.Conclusions: Adjunctive chemical approaches for implant surface decontamination may offer an advantage over sub-marginal instrumentation alone, in terms of improved PD.

Prevention and treatment of peri‐implant diseases—The EFP S3 level clinical practice guideline

“…For this guideline, a total of 13 SRs were conducted to support the guideline development process (Carra et al, 2023; Cosgarea et al, 2023; de Waal et al, 2023; Dommisch et al, 2023; Donos et al, 2023; Gennai et al, 2023; Karlsson et al, 2023; Liñares et al, 2023; Ramanauskaite et al, 2023; Stiesch et al, 2023; Teughels et al, 2023; Verket et al, 2023; Wilensky et al, 2023). The corresponding manuscripts are published within this special issue of the Journal of Clinical Periodontology .…”

“…Supporting literature (Cosgarea et al, 2023;de Waal et al, 2023;Liñares et al, 2023) and Expert opinion Quality of evidence Moderate-indirect evidence derived from 15 RCTs, with at least 6 months of follow-up (10 with low, 3 with some concerns and 2 with high risk of bias)…”

“…The group identified interventions within those detailed and performed in test and control groups of the 15 RCTs included in the three SRs (Cosgarea et al, 2023; de Waal et al, 2023; Liñares et al, 2023). Among them, the most relevant were selected and placed in chronological sequence: OH instructions and motivation, see Section 5. Risk factor control, see Section 6. Prosthesis cleaning/removal/modification, including controlling biofilm retentive factors and evaluation of the components of the prosthesis, whenever needed and feasible.…”

“…In the SRs prepared for the present project (Cosgarea et al, 2023; de Waal et al, 2023; Liñares et al, 2023), 15 RCTs with at least 6‐month follow‐up were considered as valid for developing recommendations. For the present recommendation, outcomes from both test and control groups are considered.…”

An antibacterial conjugate of carbon nanohorns for NIR-light mediated peri-implantitis treatment

“…The complex threedimensional surface structure makes it difficult to remove bacteria, limiting the success of most treatment modalities, including surgery. 15,16 One treatment for peri-implantitis is the topical administration of antibiotics. Because of the diverse microflora present in peri-implantitis lesions, broad-spectrum antibiotics are used.…”