“…The above results guaranteed that rTPA@ms-QD possesses both abilities of bright photolabeling and photoinduced 1 O 2 generation, which is useful for medical applications of photo-mediated cancer or bacterial killing. 46,57 Thus, rTPA@ms-QD was tested in a spheroid, a living cellular assembly consisting of more than hundreds of cells that mimic realistic tissues. 58 Because spheroids are usually much thicker specimens than conventionally cultured cells on a dish, higher luminescence is required to clearly visualize the photo label under microscopic observations.…”