Efficacy of chalcone and xanthine derivatives on lipase inhibition: A systematic review

Abstract

Tam and Mostafa are contributed equally to work.Our review provided efficient candidates of compounds with chalcone scaffold and their characteristics which can be beneficial for discovering further new drugs. Correspondence AbstractLosing weight has significant impact on chronic disease management. Orlistat, a lipase inhibitor, has alternative effect for weight controlling. To find more candidates, we conducted a review of chalcone and xanthine derivatives regarding their anti-lipase activity. Eight databases were searched including PubMed, Scopus, Web of Science (ISI), Virtual Health Library (VHL), System for Information on Grey Literature in Europe (SIGLE), Global Health Library (GHL), EMBASE, and Google Scholar in August 2018. We found chalcone scaffold was more effective on lipase inhibition than xanthine scaffold. Among 19 investigated chalcones, only isoliquiritigenin and licuroside demonstrated an effect on preventing weight gain and increase in the total cholesterol and total triglycerides aside apart from their high activity on inhibiting lipase. Effect and type of inhibition of individual chalcones differed depending on their structure. In addition, very few studies investigated xanthine compounds and their activities were inconsistent. We suggest more studies investigate 206 |

Characterization, Antioxidant Activities, and Pancreatic Lipase Inhibitory Effect of Extract From the Edible Insect Polyrhachis vicina

“…Furthermore, orlistat interacted with the amino acid residue (Ser153) at the active site of PL through a conventional hydrogen bond at a distance of 2.7 Å ( 41 ). The findings of this study suggest that similar to orlistat, polyphenols may function as PL inhibitors by competing with the substrate for the active site of PL ( 42 ). Currently, the relationship between docking results, mode of interaction, sites, and inhibitory activity is unclear.…”