Anti-obesity, antioxidant and in silico evaluation of Justicia carnea bioactive compounds as potential inhibitors of an enzyme linked with obesity: Insights from kinetics, semi-empirical quantum mechanics and molecular docking analysis

Anigboro, Akpovwehwee A.; Avwioroko, Oghenetega J.; Akeghware, Onoriode; Tonukari, Nyerhovwo J.

doi:10.1016/j.bpc.2021.106607

Cited by 21 publications

(14 citation statements)

References 55 publications

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“…Furthermore, orlistat interacted with the amino acid residue (Ser153) at the active site of PL through a conventional hydrogen bond at a distance of 2.7 Å ( 41 ). The findings of this study suggest that similar to orlistat, polyphenols may function as PL inhibitors by competing with the substrate for the active site of PL ( 42 ).…”

Section: Resultsmentioning

confidence: 99%

Characterization, Antioxidant Activities, and Pancreatic Lipase Inhibitory Effect of Extract From the Edible Insect Polyrhachis vicina

et al. 2022

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Oxidative stress and obesity are critical risk factors for metabolic syndrome. The consumption of functional food ingredients can a viable strategy to alleviate oxidative stress and obesity. In this study, the hydro-ethanolic extract of the edible insect Polyrhachis vicina was prepared and its bioactive components were characterized. The total polyphenol contents, total flavonoid contents, antioxidant and pancreatic lipase (PL) inhibitory activities of the extract were determined in vitro. In total, 60 bioactive components were tentatively identified in the P. vicina extract. Polyphenols and fatty acids were further quantified using LC-MS and GC-MS, respectively. P. vicina extract possessed excellent antioxidant and PL inhibition activities. Salicylic acid, gallic acid, liquiritigenin, and naringenin, which were the major polyphenols in the P. vicina extract, interacted with PL through hydrogen bonding, hydrophilic or hydrophobic and pi-cation interactions. Thus, P. vicina extract can be used as a nutraceutical to alleviate oxidative stress-induced disease and manage obesity.

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Section: Resultsmentioning

confidence: 99%

Characterization, Antioxidant Activities, and Pancreatic Lipase Inhibitory Effect of Extract From the Edible Insect Polyrhachis vicina

et al. 2022

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“…)]-, oleic acid and ethyl oleate (Table 2). Several plants possessing some of these phytochemicals have been reported to possess different pharmacological benefits such anticancer, antiinflammatory, antioxidant, antidiabetic and hypolipidemic effects (Paudel et al, 2018;Naz et al, 2020;Batiha et al, 2020;Nokhala et al, 2020;Al-Nemari et al, 2020;Anigboro et al, 2021). Therefore, the presence of these compounds in extracts of Irvingia gabonensis may reflect the variety of pharmacological benefits attributed to the plant.…”

Section: Bioactive Compounds Identified By Gc-ms Fingerprintingmentioning

confidence: 99%

Evaluation of chemical composition, in vitro antioxidant, and antidiabetic activities of solvent extracts of Irvingia gabonensis leaves

Atanu

Ikeojukwu

Owolabi

et al. 2022

Heliyon

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“…With the change in lifestyles, the treatment of obesity is gradually shifting from drug treatment to dietary intervention and prevention [3]. Studies have shown that obesity is closely related to oxidative stress [4,5] and that dietary supplementation with antioxidants has a potential therapeutic effect on weight loss or control [6,7]. Therefore, 2 of 18 there is an urgent need to develop functional foods that offer long-term prevention of obesity and antioxidant activity.…”

Section: Introductionmentioning

confidence: 99%

Development of Functional Kiwifruit Jelly with chenpi (FKJ) by 3D Food Printing Technology and Its Anti-Obesity and Antioxidant Potentials

Peng

Gao

Liao

et al. 2022

Foods

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With the growing popularity of the concept of healthy diet, modern obesity treatment is gradually shifting from surgical or pharmacological treatment to nutritional intervention. As a safe and effective measure, natural product interventions are a potential strategy of obesity management. The present study aimed to develop a kind of functional food rich in bioactive compounds (chenpi, kiwifruit, and pectin as raw materials) and investigate their bioactive effects on a mouse model. For development of functional kiwifruit jelly with chenpi (FKJ), the results of single-factor and response surface experiments showed that the optimized formulation was composed of a 30.26% addition of chenpi, 35% addition of kiwifruit juice, and 2.88% addition of pectin. The FKJ obtained with the optimal formulation could be used as a 3D printing raw material to print the desired food shapes successfully. For bioactivity evaluation of FKJ, the results with a mouse model showed that the food intake, liver weight, and adipose tissue weight were significantly decreased after administration of FKJ with dose-dependent effect compared to the CON group (p < 0.05). Meanwhile, the serum levels of several inflammatory factors (TG, IL-6, and TNF-α) were decreased and the activities of several antioxidant-related enzymes (SOD, GSH-PX, and CAT) were increased. In short, a functional kiwifruit jelly with chenpi was developed in this study. It is a functional snack food rich in active phenolic compounds, low in calories, with antioxidant and anti-inflammatory activity, and prevents fat accumulation. FKJ could well meet the needs of modern people for nutrition and health and also promote the processing and utilization of natural products, and has good development prospects in the functional food industry.

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Anti-obesity, antioxidant and in silico evaluation of Justicia carnea bioactive compounds as potential inhibitors of an enzyme linked with obesity: Insights from kinetics, semi-empirical quantum mechanics and molecular docking analysis

Cited by 21 publications

References 55 publications

Characterization, Antioxidant Activities, and Pancreatic Lipase Inhibitory Effect of Extract From the Edible Insect Polyrhachis vicina

Characterization, Antioxidant Activities, and Pancreatic Lipase Inhibitory Effect of Extract From the Edible Insect Polyrhachis vicina

Evaluation of chemical composition, in vitro antioxidant, and antidiabetic activities of solvent extracts of Irvingia gabonensis leaves

Development of Functional Kiwifruit Jelly with chenpi (FKJ) by 3D Food Printing Technology and Its Anti-Obesity and Antioxidant Potentials

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