Efficacy of Cetylpyridinium Chloride Used as Oropharyngeal Antiseptic

Pitten, Frank-Albert; Krämer, Axel

doi:10.1055/s-0031-1300084

Cited by 56 publications

(62 citation statements)

References 29 publications

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“…The combination of CPC with chlorhexidine and zinc lactate brings the highest reduction of both anaerobic and aerobic microorganisms, thus preventing the occurrence of bad breath (11). The effectiveness of CPC against oropharingeal candidiase has also been confi rmed (12).…”

Section: Introductionmentioning

confidence: 97%

Antibacterial effects of conventional glass ionomer cement

Dimkov¹,

Gjorgievska²,

Nicholson³

et al. 2016

BLL

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OBJECTIVES: The antibacterial activity of conventional glass ionomer cement against three different microorganism strains alone and following incorporation of 1, 2 and 3 % Benzalkonium Chloride and Cetylpyridinium Chloride was evaluated. METHODS: Agar diffusion method was used to determine the inhibitory effect of the conventional glass ionomer cement ChemFlex on Streptococcus mutans, Lactobacillus casei and Actinomyces viscosus. Bacterial strains were inoculated into BHIB, and incubated in an anaerobic atmosphere (37 °C). From the bacteria grown in the liquid medium, the density of the inoculum was set to be equivalent to McFarland 2 standard. In Shaedler agar, 350 μL of the bacterial suspension were equally spread. Specimens (4 mm × 6 mm) were prepared from the cement without and with addition of 1, 2 and 3 % Benzalkonium Chloride and Cetylpyridinium Chloride. The inhibition zones were determined after 48 hours, after 2, 7 and 21 days of incubation. RESULTS: The combination ChemFlex + Benzalkonium Chloride has the best effect on the three analysed bacteria. The Benzalkonium Chloride antibacterial compound has a stronger antibacterial effect than Cetylpyridinium Chloride. CONCLUSIONS: Glass ionomer cements can potentially be used as a medium for slow release of active antimicrobial components, and they have the potential to improve clinical outcomes of the cements (Tab. 3, Fig. 3, Ref. 31). Text in PDF www.elis.sk.

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Section: Introductionmentioning

confidence: 97%

Antibacterial effects of conventional glass ionomer cement

Dimkov¹,

Gjorgievska²,

Nicholson³

et al. 2016

BLL

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“…As a surface-active agent, it has a broad antimicrobial spectrum and is particularly effective at killing Gram-positive pathogens and yeasts. 12) CPC has been shown to significantly improve plaque-associated gingivitis, which can precede periodontitis. 19) Alveolar bone resorption as a result of enhanced osteoclast activity is commonly observed in periodontitis.…”

Section: Discussionmentioning

confidence: 99%

“…It is an antiseptic agent with a broad antimicrobial spectrum and has rapid bactericidal effects on Gram-positive pathogens and fungicidal effects on yeasts. 12) It is assumed that it kills bacteria by disturbing membrane function, thereby causing leakage of cytoplasmic material and ultimately the collapse of the intracellular equilibrium. 12,13) Research has demonstrated that CPC is effective in preventing gingival inflammation, thereby helping to prevent periodontitis.…”

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confidence: 99%

“…12) It is assumed that it kills bacteria by disturbing membrane function, thereby causing leakage of cytoplasmic material and ultimately the collapse of the intracellular equilibrium. 12,13) Research has demonstrated that CPC is effective in preventing gingival inflammation, thereby helping to prevent periodontitis. 14) Although osteoclasts have been shown to resorb alveolar bone in periodontitis, little is known about the direct effects of CPC on osteoclasts.…”

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confidence: 99%

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Cetylpyridinium Chloride Inhibits Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Formation

Zheng

Chen

Noh

et al. 2013

Biological & Pharmaceutical Bulletin

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Osteoclasts are responsible for bone erosion in diseases as diverse as osteoporosis, periodontitis, and rheumatoid arthritis. Antiseptic products have received recent attention as potential therapeutic and preventive drugs in human disease. The purpose of this study was to investigate the effect of the antiseptic cetylpyridinium chloride (CPC) on osteoclast formation using mouse bone marrow-derived macrophages (BMMs). CPC inhibited receptor activator of nuclear factor (NF)-κB ligand (RANKL)-induced osteoclast formation in a dose-dependent manner without causing cytotoxicity. The mRNA expression of cathepsin K, calcitonin receptor (CTR), and Prdm1 in osteoclasts was reduced by CPC. In experiments to elucidate its mechanism of action, CPC was found to suppress RANKL-induced expression of c-Fos and nuclear factor of activated T cells (NFATc1), transcription factors that are essential for osteoclast differentiation. CPC also inhibited RANKL-induced activation of extracellular signal-regulated kinase (ERK) and NF-κB and expression of cyclooxygenase (COX)-2. These results collectively suggest that CPC inhibits osteoclast differentiation by suppressing the activation of ERK and NF-κB and reducing the expression of COX-2, c-Fos, and NFATc1. CPC may therefore be a useful drug in the prevention of bone loss.

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“…A number of laboratory studies are available in the literature that report the broad spectrum activity of CPC on a range of organisms, including bacteria and yeast found in dental plaque [3][4][5]. a moderate plaque inhibition was obtained when CPC was applied twice daily as a mouthwash [6].…”

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confidence: 99%

Formulation Development And Invitro Evaluation Of Matrix Type Transdermal Drug Delivery System Using Cetyl Pyridinium

Yerragunta¹

2017

IJNME

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Research ArticleOpen Access ISSN 2474-8811 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Received April 18, 2017 Accepted May 20, 2017 Published June 06, 2017At present, the most common form of delivery of drugs is the oral route, its advantage of easy administration. It also has significant drawbacks -poor bioavailability due to hepatic metabolism (first pass) and the tendency to produce rapid blood level spikes, which can be both cost prohibitive and inconvenient.To overcome these difficulties there is a need for the development of new drug delivery system; which will improve the therapeutic efficacy and safety of drugs. Hence in present work, an attempt is been made to provide development and optimization a matrix type Transdermal drug delivery system using water insoluble polymers with model drug as Cetylpyridinium and to study the effect of various concentration of polymers on In-vitro membrane permeation studies. AbstractKeywords: Cetylpyridinium , TDDS. IntroductionOral drug administration has been the predominant route for drug delivery over decades. Most conventional oral drug products, such as tablets and capsules, are formulated to release the active drug immediately after oral administration [1][2]. Delivery of drugs through the skin has been always a challenging area for research due to barrier properties exhibit by the outermost layer of skin stratum corneum. In the last two decades, the transdermal drug delivery system has become a proven technology that offers significant clinical benefits over other dosage forms. Because transdermal drug delivery offers controlled as well as predetermined rate of release of the drug into the patient, it able to maintain steady state blood concentration. It's a desirable form of drug delivery because of the obvious advantages.Example. Convenient and pain-free self-administration for patients, avoidance of hepatic first-pass metabolism and the GI tract for poorly bioavailable drugs over other routes of delivery.CPC, an amphiphilic quaternary compound, has been used extensively in oral hygiene formulations. Valuable, properties of International Journal of Nanotechnology in Medicine & Engineering 73CPC include solubility in water and alcohol, as well as its ability to reduce surface tension. A number of laboratory studies are available in the literature that report the broad spectrum activity of CPC on a range of organisms, including bacteria and yeast found in dental plaque [3][4][5]. a moderate plaque inhibition was obtained when CPC was applied twice daily as a mouthwash [6]. Materials and Methods MaterialsCetylpyridinium Chloride, potassium dihydrogen phosphate and lactose were purchased from pharmatech laboratories, Hyderabad. Eudragilt-L100, Propylene Glycol, Dimethyl formamide, Ethanol. All chemicals and solvents were of analytical grade. Freshly double distilled water was used in the experiments.Preparation of Phosphate Buffer pH 7.4: Accurately measu...

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Efficacy of Cetylpyridinium Chloride Used as Oropharyngeal Antiseptic

Cited by 56 publications

References 29 publications

Antibacterial effects of conventional glass ionomer cement

Antibacterial effects of conventional glass ionomer cement

Cetylpyridinium Chloride Inhibits Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Formation

Formulation Development And Invitro Evaluation Of Matrix Type Transdermal Drug Delivery System Using Cetyl Pyridinium

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