Formulation Development And Invitro Evaluation Of Matrix Type Transdermal Drug Delivery System Using Cetyl Pyridinium

Abstract

Research ArticleOpen Access ISSN 2474-8811 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Received April 18, 2017 Accepted May 20, 2017 Published June 06, 2017At present, the most common form of delivery of drugs is the oral route, its advantage of easy administration. It also has significant drawbacks -poor bioavailability due to hepatic metabolism (first pass) and the tendency to produce rapid blood level spikes, which can be both cost prohibitive and inconvenient.To overcome these difficulties there is a need for the development of new drug delivery system; which will improve the therapeutic efficacy and safety of drugs. Hence in present work, an attempt is been made to provide development and optimization a matrix type Transdermal drug delivery system using water insoluble polymers with model drug as Cetylpyridinium and to study the effect of various concentration of polymers on In-vitro membrane permeation studies. AbstractKeywords: Cetylpyridinium , TDDS. IntroductionOral drug administration has been the predominant route for drug delivery over decades. Most conventional oral drug products, such as tablets and capsules, are formulated to release the active drug immediately after oral administration [1][2]. Delivery of drugs through the skin has been always a challenging area for research due to barrier properties exhibit by the outermost layer of skin stratum corneum. In the last two decades, the transdermal drug delivery system has become a proven technology that offers significant clinical benefits over other dosage forms. Because transdermal drug delivery offers controlled as well as predetermined rate of release of the drug into the patient, it able to maintain steady state blood concentration. It's a desirable form of drug delivery because of the obvious advantages.Example. Convenient and pain-free self-administration for patients, avoidance of hepatic first-pass metabolism and the GI tract for poorly bioavailable drugs over other routes of delivery.CPC, an amphiphilic quaternary compound, has been used extensively in oral hygiene formulations. Valuable, properties of International Journal of Nanotechnology in Medicine & Engineering 73CPC include solubility in water and alcohol, as well as its ability to reduce surface tension. A number of laboratory studies are available in the literature that report the broad spectrum activity of CPC on a range of organisms, including bacteria and yeast found in dental plaque [3][4][5]. a moderate plaque inhibition was obtained when CPC was applied twice daily as a mouthwash [6]. Materials and Methods MaterialsCetylpyridinium Chloride, potassium dihydrogen phosphate and lactose were purchased from pharmatech laboratories, Hyderabad. Eudragilt-L100, Propylene Glycol, Dimethyl formamide, Ethanol. All chemicals and solvents were of analytical grade. Freshly double distilled water was used in the experiments.Preparation of Phosphate Buffer pH 7.4: Accurately measu...