Efficacy of certolizumab pegol: a case study in a patient with rheumatoid arthritis on maintenance hemodialysis

Nishimura, Akito; Minegishi, Yojiro; Kwamura, Keiko; Ichino, Asako; Uchiyama, Katsufumi

doi:10.1007/s00296-015-3225-1

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…However, methotrexate is difficult to use in patients on dialysis because of renal failure. Previous reports have shown that biologics are effective in patients with high disease activity rheumatoid arthritis on maintenance dialysis, and there have been reports on the use of TNF-α antibody agents, such as certolizumab pegol and etanercept, and non-TNF-α antibody agents, such as tocilizumab, in patients on dialysis 5 , 6 , 7 , 8 ) . However, no reports have been found on the response to the secondary ineffectiveness of these biologics.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of peficitinib in two patients with rheumatoid arthritis on maintenance hemodialysis

et al. 2022

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Objective: Treatment options for patients with rheumatoid arthritis on maintenance hemodialysis with an inadequate response to biologic agents have not been reported. In this report, we describe two patients who achieved remission after treatment with peficitinib. Methods: Two 69-and 85-year-old patients with rheumatoid arthritis on maintenance hemodialysis were previously treated with biologics and started on peficitinib 100 mg/day after the secondary failure of biologics. Discussion: In the two cases presented here, rheumatoid arthritis was almost in remission and there were no adverse events, although the patients were switched to peficitinib after secondary failure of the biologic agents. Among Janus kinase inhibitors, peficitinib has the lowest renal excretion; therefore, its administration in patients on dialysis is not contraindicated according to the package insert in Japan. The use of biologic agents in patients on hemodialysis has been reported to be associated with a high incidence of infections; therefore, care should be taken to avoid infections when administering Janus kinase inhibitors. Conclusion: Janus kinase inhibitors with low renal excretion, such as peficitinib, may be effective in patients with rheumatoid arthritis on maintenance hemodialysis who have an inadequate response to biologic agents.

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Section: Discussionmentioning

confidence: 99%