Efficacy of calcium- and fluoride-containing materials for the remineralization of primary teeth with early enamel lesion

Memarpour, Mahtab; Soltanimehr, Elham; Sattarahmady, N.

doi:10.1002/jemt.22543

Cited by 33 publications

(53 citation statements)

References 26 publications

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“…Evidence-based review and research studies on the calcium phosphate agent for prevention of tooth caries in children indicated that calcium and phosphate ion promote remineralization of early enamel caries,[37383940414243444546474849] which is in line with the results of this study; however, which type of calcium phosphate compound is the best remineralizing agent is still controversial. [4243444546474849]…”

Section: Discussionsupporting

confidence: 84%

The efficiency of child formula dentifrices containing different calcium and phosphate compounds on artificial enamel caries

Rirattanapong¹,

Vongsavan²,

Saengsirinavin³

et al. 2016

J Int Soc Prevent Communit Dent

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Objectives:Fluoride toothpaste has been extensively used to prevent dental caries. However, the risk of fluorosis is concerning, especially in young children. Calcium phosphate has been an effective remineralizing agent and is present in commercial dental products, with no risk of fluorosis to users. This in vitro study aimed to compare the effects of different calcium phosphate compounds and fluoride-containing dentifrices on artificial caries in primary teeth.Materials and Methods:Fifty sound primary incisors were coated with nail varnish, leaving two 1 mm2 windows on the labial surface before immersion in demineralizing solution for 96 hours to produce artificial enamel lesions. Subsequently, one window from each tooth was coated with nail varnish, and all 50 teeth were divided into five groups (n = 10); group A – deionized water; group B – casein phosphopeptide–amorphous calcium phosphate (CPP–ACP) paste (Tooth Mousse); group C – 500 ppm F (Colgate Spiderman®); group D – nonfluoridated toothpaste with triple calcium phosphate (Pureen®); and group E – tricalcium phosphate (TCP). Polarized light microscopy and Image-Pro® Plus software were used to evaluate lesions.Results:After a 7-day pH-cycle, mean lesion depths in groups A, B, C, D, and E had increased by 57.52 ± 10.66%, 33.28 ± 10.16%, 17.04 ± 4.76%, 32.51 ± 8.99%, and 21.76 ± 8.15%, respectively. All data were processed by the Statistical Package for the Social Sciences (version 16.0) software package. Comparison of percentage changes using one-way analysis of variance and Fisher's least squares difference tests at a 95% level of confidence demonstrated that group A was significantly different from the other groups (P < 0.001). Lesions in groups B and D had a significant lesion progression when compared with groups C and E.Conclusions:All toothpastes in this study had the potential to delay the demineralization progression of artificial enamel caries in primary teeth. The fluoride 500 ppm and TCP toothpastes were equal in the deceleration of enamel caries progression and better than CPP–ACP paste and TCP toothpaste.

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Section: Discussionsupporting

confidence: 84%

The efficiency of child formula dentifrices containing different calcium and phosphate compounds on artificial enamel caries

Rirattanapong¹,

Vongsavan²,

Saengsirinavin³

et al. 2016

J Int Soc Prevent Communit Dent

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“…Only one study had low risk of bias in blinding of outcome assessment and the rest had unclear risks of bias. Overall, the included studies in vitro had unclear risks of random-sequence generation and allocation concealment [24,[28][29][30][31][32][33][34][35].…”

Section: Assessment Of Methodological Qualitymentioning

confidence: 99%

“…All three studies provided average surface roughness data and were included in the analysis [15,24,31]. When the data from the three studies were pooled, no significant heterogeneity was found (Chi 2 = 2.77, df = 2, P = 0.25, I 2 = 28%).…”

Section: Average Surface Roughness From In Vitro Experimentationmentioning

confidence: 99%

Evaluation of the efficacy of casein phosphopeptide-amorphous calcium phosphate on remineralization of white spot lesions in vitro and clinical research: A systematic review and meta-analysis

Lin

Zhong

et al. 2019

Preprint

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Background: This systematic review with meta-analyses sought to answer whether casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) provided a remineralizing benefit superior to that of nonintervention or placebo. Methods: The Cochrane databases, PubMed, EmBase, and Ovid up to May 20th, 2019, were scanned, only published in English. Study information extraction and methodological quality assessments were accomplished independently by two reviewers. The “Criteria for judging risk of bias in the ‘Risk of bias’ assessment tool” was used for methodological quality assessment. The continuous data was analyzed by mean difference (MD) or standardized mean difference (SMD) with a 95% confidence interval (CI). Review Manager 5.3 was used for statistical analysis. Outcome variables include quantitative light-induced fluorescence in clinical research, average surface roughness and surface microhardness in vitro. Results: There were significant differences in the quantitative light-induced fluorescence (SMD = −0.43, 95% CI: [−0.79, −0.07], P = 0.02), average surface roughness (SMD = −8.21, 95% CI: [−10.37, −6.04], P < 0.01), Vickers microhardness (SMD = 1.19, 95% CI: [0.72, 1.66], P < 0.01), and Knoop microhardness (SMD = 3.52, 95% CI: [2.68, 4.36], P < 0.01) between the CPP-ACP and control groups or baseline. Conclusion: Within the limitations of this meta-analysis, CPP-ACP exhibited excellent remineralization effects evaluated in clinical research and in vitro, indicating outstanding restoration of form, aesthetics, and function in treating white spot lesions.

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“…relative to the composition of dental enamel [12,14]. Therefore, the change of concentration for both organic and inorganic substances in the oral fluid results in a decrease in the gradient relative to dental biofilm, impacting on the state of the dental enamel health [15][16][17][18]. Consequently, studies of the impact of exogenous and endogenous preventive drugs on the change in the molecular composition of the oral fluid are relevant.…”

Section: +mentioning

confidence: 99%

“…The investigation and comparison of different prevention methods, including fluoridation, will determine which phosphorusand calcium-containing agents promote the recovery of dental enamel [11,15,[19][20][21][22][23]. The prophylactic efficiency of exogenous methods, namely tooth brushing, gel application and laser irradiation, has been demonstrated [20,21,[24][25][26][27][28].…”

Section: +mentioning

confidence: 99%

Does dentifrice provide the necessary saturation of ions in oral fluids to favour remineralisation?

Seredin¹,

Goloshchapov²,

Yuri³

et al. 2018

Russ Open Med J

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Background -Changes in the molecular composition of mixed human saliva using endogenous and exogenous methods of caries prevention were studied and the duration of these changes in relation to the initial state of the oral fluid was determined. Material and Methods -In total, 200 European healthy, addiction-free, university-educated males and females, aged 22-30 were recruited for the study. Participants collected their mixed saliva samples after the use of a multi-mineral toothpaste (exogenous prevention) and after three days of taking a calcium glycerophosphate tablet (endogenous prevention). In the first stage of the study, samples of mixed saliva were analysed by infrared (IR) lab spectrometer and equipment of infrared microspectroscopy beamline at the Australian Synchrotron (Victoria, Australia) was used in the second stage of study. Results -Based on the experimental data obtained by IR-spectroscopy technique, the mineral/organic and carbon/phosphate ratios were calculated. The changes in the organic mineral balance of the oral cavity induced by these two preventive methods were analysed. The statistical significance of the results for the confidence level of p is indicated. The data shows that changes in the molecular composition of mixed saliva when using an exogenous method of caries prevention only provides a short-term effect, continuing for the first 30 minutes after the preceding prevention. Moreover, calcium glycerophosphate tablets can change the organic-mineral balance in mixed saliva, increasing the content of mineral groups and complexes. The content of endogenous, biologically accessible phosphate groups and complexes in the mixed saliva exceeds by approximately 12% that of the mixed saliva before the use of the prevention agents. Conclusion -Use of calcium glycerophosphate tablets in combination with brushing (a combination of endogenous and exogenous prevention methods) leads to the long-term presence of high concentrations of ions, mineral complexes and groups (phosphates) in the oral fluid.

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Efficacy of calcium- and fluoride-containing materials for the remineralization of primary teeth with early enamel lesion

Cited by 33 publications

References 26 publications

The efficiency of child formula dentifrices containing different calcium and phosphate compounds on artificial enamel caries

The efficiency of child formula dentifrices containing different calcium and phosphate compounds on artificial enamel caries

Evaluation of the efficacy of casein phosphopeptide-amorphous calcium phosphate on remineralization of white spot lesions in vitro and clinical research: A systematic review and meta-analysis

Does dentifrice provide the necessary saturation of ions in oral fluids to favour remineralisation?

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