Efficacy of Botulinum Toxin Type??A??in??the??Relief of Carpal??Tunnel??Syndrome

Abstract

Our data suggest long-lasting antinociceptive effects of botulinum toxin A rather than electrophysiological restoration in patients with CTS. Intracarpal injection of botulinum toxin A was shown to be well tolerated and safe. A double-blind, placebo-controlled trial of botulinum toxin A in CTS is warranted since the current study may have been confounded by the placebo effect of intracarpal injection.

Botulinum Toxin for Neuropathic Pain and Spasticity: An Overview

“…The investigators injected a total of 60 U intracarpally and followed the patients monthly for 3 months. [36] The patients experienced no weakness, unlike that seen in the study by Breuer et al, probably since the abobotulinumtoxinA was not injected into the muscle. While there was a trend toward pain improvement in three patients, the finding was not significant.…”

“…Based on one class I study [35] and one class IV study [36] that showed no significant effect on pain following BoNT injection for carpal tunnel syndrome pain, the use of BoNT is probably not effective (level B evidence) ( Table 4). …”

Abstracts and Highlight Papers of the 31st Annual European Society of Regional Anaesthesia (ESRA) Congress 2012

“…The effect of epidural volume extension with 5 ml saline on spinal blockade as part of a combined spinal epidural technique in 90 term parturient undergoing elective CS has been reported as deprived of benefits 54 . Kucukguclu et al 55 .…”

“…The LANSS scale is a simple and suitable screening test for neuropathic pain in patients with HNC pain, (sensitivity 79%; specificity 100%), although some modifications might improve it. [54] Chemotherapy-induced painful peripheral neuropathies (CIPN) are increasing in frequency as more neurotoxic agents are introduced to treat cancer. Patients describe symmetrical, distal painful neuropathy in a ''stocking and glove'' distribution, usually in the feet/toes and fingers/hands/.…”

“…This technology employs bipolar RF electrodes andbased on improvement in pain scores and functional capacity in patients with discogenic pain -is likely the most promising of all currently available minimally invasive, disk-heating methods (51)(52)(53)(54)(55). This method works specifically by concentrating RF current between the ends of two straight probes.…”