Efficacy of betamethasone valerate foam formulation in comparison with betamethasone dipropionate lotion in the treatment of mild‐to‐moderate alopecia areata: A multicenter, prospective, randomized, controlled, investigator‐blinded trial

Mancuso, Giuseppe; Balducci, Antonella; Casadio, Chiara; Farina, Paolo; Staffa, Mauro; Valenti, Lorenzo; Milani, Massimo

doi:10.1046/j.1365-4362.2003.01862.x

Cited by 65 publications

(32 citation statements)

References 14 publications

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“…They are thought to work by suppressing the robust autoimmune inflammatory reaction seen in alopecia areata. Betamethasone valerate in a foam vehicle showed increased efficacy in mild-to-moderate alopecia areata versus a lotion vehicle, with 23 of 31 compared with nine of 30 patients showing increased growth of at least 50% [22]. There was no vehicle control.…”

Section: Topical Corticosteroidsmentioning

confidence: 97%

An update on alopecia areata

Kos

Conlon²

2009

Current Opinion in Pediatrics

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Section: Topical Corticosteroidsmentioning

confidence: 97%

An update on alopecia areata

Kos

Conlon²

2009

Current Opinion in Pediatrics

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“…In another study done by Mancuso G et al, 4 a RGS>3 was observed in 61% of the patients treated with Betamethasone valerate foam. And a RGS>3 was seen in 27% of patients treated with betamethasone dipropionate lotion.…”

Section: Discussionmentioning

confidence: 81%

Comparison of Efficacy of Various Topical Treatment Modalities in Alopecia Areata

Hogade¹,

Hussain²

2015

jemds

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BACKGROUND:Alopecia areata is one of the common causes of localized hair loss. Alopecia areata can have spontaneous remission or can follow unpredictable course with exacerbation. Due to which it can be a cause of cosmetic concern for the patient. AIM: To know the efficacy of various topical treatment modalities in Alopecia areata. METHODS: 100 patients presenting with alopecia areata to the dermatology outpatient department of Basaveshwar Teaching and General Hospital and Sangameshwar Hospital, Gulbarga, were included in this study. It was conducted as a randomized prospective study for a period of 12 weeks after taking an informed consent from the patient. Patients were randomly distributed into four treatment groups -A, B, C, D. Group. A were treated with 0.05% Betamethasone Dipropionate cream applied twice daily, Group. B were treated with 2% Minoxidil solution applied 1ml twice daily, Group. C was treated with 1.15% Anthralin ointment applied daily for 15 minutes and Group. D were treated with 0.03% Tacrolimus applied twice daily to the affected areas. Alopecia Grading Scale (AGS) was calculated at first visit and 12 weeks. Regrowth Score (RGS) was calculated at 12 weeks. Treatment outcome in different groups were compared using mean AGS at 12 weeks and RGS. RESULTS: Group A patients showed statistically significant clinical improvement when compared to all the other groups. Poorest response was seen in Group D. CONCLUSION: The study concluded that topical 0.05% betamethasone dipropionate is the most effective topical treatment modality in patients with alopecia areata.

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“…Up to now, numerous studies have been conducted on treatment of alopecia areata and many of those researches have compared the efficacy of different topical agents on hair regrowth (14)(15)(16)(17)(18)(19)(20). In a comparative study of topical 0.05% tretinoin, topical betamethasone dipropionate lotion, and 0.25% dithranol paste, satisfaction was reported by 55% of patients who were treated with topical tretinoin in comparison with 70% and 35% of cases who were respectively underwent topical steroid and dithranol therapy (14).…”

Section: Discussionmentioning

confidence: 99%

“…In another study, the combination of 5% minoxidil and 0.5% anthralin was used to treat 51 patients with severe alopecia areata and only 11% of patients achieved cosmetically acceptable hair regrowth (17). In another study, 61% of patients using 0.1% betamethasone vale rate foam showed more than 75% hair regrowth while only 27% of patients who underwent treatment with 0.05% betamethasone dipropionate lotion had the same rate of regrowth (18). Folliculitis is a common side effect of topical corticosteroids; however, telangiectasia and atrophy may rarely develop.…”

Section: Discussionmentioning

confidence: 99%

Comparing the Efficiency of Elidel Cream and Elidel Accompanied With Tretinoin Cream in Treatment of Alopecia Areata

et al. 2014

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Background: Alopecia areata is a disorder causing local or total body hair loss. Various therapeutic modalities have been used for the treatment of this disease; however, none of them were completely effective. Objectives: In this study, we compared the efficacy of topical Elidel alone and Elidel accompanied with tretinoin in the treatment of alopecia areata. Patients and Methods: This randomized controlled clinical trial was performed on patients with alopecia areata in Rasul-e Akram Hospital in Tehran, Iran, from 2010 to 2011. Patients in the Elidel group applied Elidel 1% cream twice a day. The second group received 1% Elidel in the mornings and 0.05% tretinoin in the evenings. The results compared after three months of treatment. Results: A total of 80 patients were randomly allocated to two treatment groups. The mean age of the patients was 21.8 ± 3.9 and 21.6 ± 4.4 years in the Elidel and Elidel plus tretinoin groups, respectively (P = 0.879). There were 26 males (65%) in the Elidel and 24 (60%) male patients in Elidel plus tretinoin groups (P = 0.481). In The Elidel group, the complete cure was observed in eight patients (20%), relative cure in 14 (35%), no change in 10 (25%), and disease aggravation in 8 (20%) cases; in the Elidel plus tretinoin group, the complete cure was reported in 18 patients (45%), relative cure in 12 (30%), no change in 8 (20%), and disease aggravation in 2 (5%) (P = 0.048) cases. The cure rate in both groups significantly changed in comparison to the previous findings (P < 0.001). Conclusions: Our study showed that the combined use of Elidel and tretinoin was more effective than Elidel alone.

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Efficacy of betamethasone valerate foam formulation in comparison with betamethasone dipropionate lotion in the treatment of mild‐to‐moderate alopecia areata: A multicenter, prospective, randomized, controlled, investigator‐blinded trial

Abstract: Betamethasone valerate foam has shown to be an effective and well-tolerated treatment of mild-to-moderate AA. Further trials are warranted to evaluate the role of this new formulation in comparison or in combination with intralesional corticosterioids in AA treatment.

Cited by 65 publications

References 14 publications

An update on alopecia areata

An update on alopecia areata

Comparison of Efficacy of Various Topical Treatment Modalities in Alopecia Areata

Comparing the Efficiency of Elidel Cream and Elidel Accompanied With Tretinoin Cream in Treatment of Alopecia Areata

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