Efficacy of .beta.-Ionone in the Chemoprevention of Rat Mammary Carcinogenesis

Yu, Suzanne G.; Anderson, Peter J.; Elson, Charles E.

doi:10.1021/jf00056a035

Cited by 44 publications

(29 citation statements)

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“…Tumor incidence was decreased in a dose-dependent manner during the 24-week study. Yu et al 16 reported that the potency of b-ionone in suppressing HMGR activity exceeds these of other monoterpenes. In parallel trials, the efficacy of b-ionone was greater than that of equal intakes D-linmonene and geraniol in mammary cancer chemoprevention.…”

Section: Expression Of Apoptosis Bcl-2 and Bax In Mammary Cancer Tismentioning

confidence: 99%

“…10,12 In addition, b-ionone could also affect metastasis in B16 and SGC-7901 cancer cell lines. 11,12,15 Dietary studies reveal the chemopreventive 16 and antitumor 17 activities of b-ionone.This study confirms and extends observations of the chemopreventive impact of, and actions triggered, by dietary b-ionone during DMBA-initiated mammary carcinogenesis in Sprague-Dawley rats. …”

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confidence: 99%

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β‐Ionone suppresses mammary carcinogenesis, proliferative activity and induces apoptosis in the mammary gland of the Sprague‐Dawley rat

Liu

Sun

Dong

et al. 2008

Intl Journal of Cancer

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b-Ionone demonstrates potent anticancer activity both in vitro and in vivo. We determined tumor incidence and the number of rats bearing tumors as well as cell proliferation and apoptosis in a rat mammary cancer model induced by 7, 12-dimethylbenz[a]anthracene (DMBA). Rats were fed an AIN-76A diet containing b-ionone (0, 9, 18 or 36 mmol/kg), starting 2 weeks before DMBA administration and continuing for 24 weeks. A dose-dependent inhibition of mammary carcinogenesis by dietary b-ionone was observed. Corresponding tumor incidence values were 82.1, 53.3, 25.9 and 10.0% (p < 0.01 or 0.05). Time to tumor appearance increased and tumor multiplicity decreased with increasing dietary b-ionone. Histopathological and immunohistochemical evaluations of tumors were performed on the 64, 31, 15 and 3 tumors, respectively, identified in rats from the respective groups of 30. The proportions of adenocarcinomas, adenomas and benign masses were equally distributed in the latter group. In proportions within the other groups, the proportions of adenocarcinomas and benign masses decreased and increased with increasing dietary b-ionone. Proliferating cell nuclear antigen (PCNA), cyclin D1 and Bcl-2 expression decreased, and Bax expression and nuclear fragmentation increased with increasing dietary b-ionone. These results demonstrate the potent capacity of dietary b-ionone to suppress DMBA-initiated mammary cancer in rats. ' 2008 Wiley-Liss, Inc.Key words: b-ionone; mammary carcinogenesis; cell proliferation; apoptosis Epidemiological studies have generally shown that the consumption of vitamin-rich fruits, vegetables and whole grains is inversely associated with risks for cancer and other chronic diseases. [1][2][3][4] Failing to demonstrate an inverse relationship between cancer incidence and consumption of the vitamins prominent in these plant products, investigators have turned attention to the many classes of nutrient phytochemical constituents also present in these foods. 5 Specific isoprenoids, culled from a group of some 22,000 products of secondary plant metabolic pathways sharing a common precursor, mevalonic acid, 6 have demonstrated anticarcinogenic and chemoprotective activities. One phytochemical compound, b-ionone, an end ring analog of b-carotenoid, represents a subclass of cyclic isoprenoids. Physiological functions attributed to b-ionone include the inhibition of the growth of fungi 7 and the regulation of the synthesis of mevalonate-derived constituents. 8 In previous studies, b-ionone inhibited the growth of breast-, gastric-, colon-and HL-60-cancer cells in a dosedependent manner, 9-13 affected the MAPK pathway of MDA MB 435 cells, 14 and induced apoptosis of SGC-7901 gastric cancer cells and B16 murine tumor cells. 10,12 In addition, b-ionone could also affect metastasis in B16 and SGC-7901 cancer cell lines. 11,12,15 Dietary studies reveal the chemopreventive 16 and antitumor 17 activities of b-ionone.This study confirms and extends observations of the chemopreventive impact of, and actions triggered, by diet...

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Section: Expression Of Apoptosis Bcl-2 and Bax In Mammary Cancer Tismentioning

confidence: 99%

mentioning

confidence: 99%

β‐Ionone suppresses mammary carcinogenesis, proliferative activity and induces apoptosis in the mammary gland of the Sprague‐Dawley rat

Liu

Sun

Dong

et al. 2008

Intl Journal of Cancer

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“…The new data presented here showing that treatment with GO reduced the total number of ACF in this region, as well as the number of ACF ≥4 crypts, lesions with a more advanced and aggressive phenotype (33), reinforce the idea that acyclic isoprenoids may be a chemopreventive agent against colon carcinogenesis. To the best of our knowledge, in vivo studies of chemoprevention with GO have only been conducted in liver, breast and pancreas carcinogenesis models, with inhibition of hepatic PNLs (9,10) and mammary (11,34) and pancreatic (12) neoplastic lesions, respectively. Recently, βI was reported to have chemopreventive activity in liver (8,10), breast (3,11) and colon (14) carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…GO inhibited the growth of mammary and pancreatic neoplasms in rats and hamsters, respectively (11,12), and proved to be an effective adjuvant in the treatment with 5-fluorouracil of human colorectal cancer cells transplanted in Swiss nu/ nu mice (13). βI also reduced the incidence of mammary neoplasms in rats (3,11) and, more recently, it was shown to inhibit the number and size of preneoplastic lesions (PNLs) in the colon when administered in the diet to F344 rats (14). Similarly, other isoprenoids such as perillyl alcohol (15), squalene (16), geranylgeraniol, farnesol, and lanosterol (17,18) also showed chemopreventive activity in a colon carcinogenesis model induced by azoxymethane.…”

mentioning

confidence: 96%

“…In the few available in vivo studies, both compounds exerted chemopreventive activity against hepatocarcinogenesis in rats ( [8][9][10]. GO inhibited the growth of mammary and pancreatic neoplasms in rats and hamsters, respectively (11,12), and proved to be an effective adjuvant in the treatment with 5-fluorouracil of human colorectal cancer cells transplanted in Swiss nu/ nu mice (13). βI also reduced the incidence of mammary neoplasms in rats (3,11) and, more recently, it was shown to inhibit the number and size of preneoplastic lesions (PNLs) in the colon when administered in the diet to F344 rats (14).…”

mentioning

confidence: 99%

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Efficacy of geraniol but not of β-ionone or their combination for the chemoprevention of rat colon carcinogenesis

Vieira¹,

Heidor

Cardozo

et al. 2011

Braz J Med Biol Res

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Dietary factors and the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase: Implications for breast cancer development

Duncan

El-Sohemy

Archer

2005

Mol. Nutr. Food Res.

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A role for mevalonate in cancer development has long been suggested by findings that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity is elevated in malignant cells. Increased synthesis mevalonate and mevalonate-derived nonsterol isoprenoids supports increased cell proliferation through the activation of growth-regulatory proteins and oncoproteins, and by promoting DNA synthesis. We have recently shown that mevalonate promotes the growth of human breast cancer cells both in culture and as tumors grown in nude mice. Inhibition mevalonate synthesis, therefore, may be an effective strategy to impair the growth of malignant breast cells. Several dietary compounds with known anti-cancer effects are also reported to inhibit HMG-CoA reductase activity. Here, we review evidence suggesting that inhibition of mevalonate synthesis may mediate the protective effects of cholesterol, plant isoprenoids, genistein, and long-chain n-3 polyunsaturated fatty acids (PUFAs) on experimental breast cancer.

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Efficacy of .beta.-Ionone in the Chemoprevention of Rat Mammary Carcinogenesis

Cited by 44 publications

References 28 publications

β‐Ionone suppresses mammary carcinogenesis, proliferative activity and induces apoptosis in the mammary gland of the Sprague‐Dawley rat

β‐Ionone suppresses mammary carcinogenesis, proliferative activity and induces apoptosis in the mammary gland of the Sprague‐Dawley rat

Efficacy of geraniol but not of β-ionone or their combination for the chemoprevention of rat colon carcinogenesis

Dietary factors and the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase: Implications for breast cancer development

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