Efficacy of geraniol but not of β-ionone or their combination for the chemoprevention of rat colon carcinogenesis

Vieira, Antônio Wilson; Heidor, Renato; Cardozo, Mônica Testoni; Scolastici, Clarissa; Purgatto, Eduardo; Shiga, Tsuyoshi; Barbisan, Luı́s Fernando; Ong, Thomas Prates; Moreno, Fernando Salvador

doi:10.1590/s0100-879x2011007500037

Cited by 14 publications

(13 citation statements)

References 37 publications

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“…Geraniol has been shown previously to sensitize cancer cells to the conventional chemotherapeutic agent 5-fluorouracil (5-FU), also causing an increased uptake of the drug [ 83 , 84 ]. Geraniol has also been shown to be chemoprotective towards normal colon cells in rats when administered with the potent carcinogen dimethylhydrazine [ 85 ]. This effect occurs through mediating the reduction of DNA damage when compared with controls where no EO extract was used [ 85 ].…”

Section: Synergism Of Eo Extracts With Conventional Chemotherapeutmentioning

confidence: 99%

Anticancer Properties of Essential Oils and Other Natural Products

Blowman

Magalhães

Lemos

et al. 2018

Evidence-Based Complementary and Alternative Medicine

203

119

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Essential oils are secondary metabolites with a key-role in plants protection, consisting primarily of terpenes with a volatile nature and a diverse array of chemical structures. Essential oils exhibit a wide range of bioactivities, especially antimicrobial activity, and have long been utilized for treating various human ailments and diseases. Cancer cell prevention and cytotoxicity are exhibited through a wide range of mechanisms of action, with more recent research focusing on synergistic and antagonistic activity between specific essential oils major and minor components. Essential oils have been shown to possess cancer cell targeting activity and are able to increase the efficacy of commonly used chemotherapy drugs including paclitaxel and docetaxel, having also shown proimmune functions when administered to the cancer patient. The present review represents a state-of-the-art review of the research behind the application of EOs as anticancer agents both in vitro and in vivo. Cancer cell target specificity and the use of EOs in combination with conventional chemotherapeutic strategies are also explored.

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Section: Synergism Of Eo Extracts With Conventional Chemotherapeutmentioning

confidence: 99%

Anticancer Properties of Essential Oils and Other Natural Products

Blowman

Magalhães

Lemos

et al. 2018

Evidence-Based Complementary and Alternative Medicine

203

119

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“…Geraniol (GO; 3,7-dimethyl-2,6 octadien-1-ol) is a monoterpene alcohol naturally found in the essential oil of rose and lemon [ 10 ]. In rats, GO is rapidly absorbed to reach peak plasma concentration after 34 min [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Geraniol, Alone and in Combination with Pioglitazone, Ameliorates Fructose-Induced Metabolic Syndrome in Rats via the Modulation of Both Inflammatory and Oxidative Stress Status

2015

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Geraniol (GO) potent antitumor and chemopreventive effects are attributed to its antioxidant and anti-inflammatory properties. In the current study, the potential efficacy of GO (250 mg/kg) in ameliorating metabolic syndrome (MetS) induced by fructose in drinking water was elucidated. Moreover, the effect of pioglitazone (5 and 10 mg/kg; PIO) and the possible interaction of the co-treatment of GO with PIO5 were studied in the MetS model. After 4 weeks of treatment, GO and/or PIO reduced the fasting blood glucose and the glycemic excursion in the intraperitoneal glucose tolerance test. GO and PIO5/10 restrained visceral adiposity and partly the body weight gain. The decreased level of peroxisome proliferator activated receptor (PPAR)-γ transcriptional activity in the visceral adipose tissue of MetS rats was increased by single treatment regimens. Though GO did not affect MetS-induced hyperinsulinemia, PIO5/10 lowered it. Additionally, GO and PIO5/10 suppressed glycated hemoglobin and the receptor for advanced glycated end products (RAGE). These single regimens also ameliorated hyperuricemia, the disrupted lipid profile, and the elevated systolic blood pressure evoked by MetS. The rise in serum transaminases, interleukin-1β, and tumor necrosis factor-α, as well as hepatic lipid peroxides and nitric oxide (NO) was lowered by the single treatments to different extents. Moreover, hepatic non-protein thiols, as well as serum NO and adiponectin were enhanced by single regimens. Similar effects were reached by the combination of GO with PIO5; however, a potentiative interaction was noted on fasting serum insulin level, while synergistic effects were reflected as improved insulin sensitivity, as well as reduced RAGE and triglycerides. Therefore, GO via the transcriptional activation of PPAR-γ reduces inflammation and free radical injury produced by MetS. Thereby, these effects provide novel mechanistic insights on GO management of MetS associated critical risk factors. Moreover, the co-administration of GO to PIO5 exalted the antidiabetic drug anti-MetS efficacy.

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“…Geraniol has been demonstrated to affect many signaling molecules and pathways that represent cancer hallmarks, such as sustaining proliferative signaling ( 26 , 43 – 47 ), evading growth suppressors ( 30 ), enabling replicative immortality ( 22 , 23 , 25 , 28 , 46 , 48 – 50 ), tumor-promoting inflammation ( 6 – 8 , 45 , 46 , 50 – 53 ), inducing angiogenesis ( 46 , 54 ), genome instability and mutation ( 49 ), and resisting cell death ( 25 , 26 , 30 , 45 , 46 , 49 , 50 , 54 ) and deregulating cellular energetics ( 23 , 24 , 26 , 29 – 31 , 47 , 52 ). The pleiotropic effects of geraniol on cancer hallmarks are schematically illustrated in Fig.…”

Section: The Effects Of Geraniol On Cancer Hallmarksmentioning

confidence: 99%

“…Geraniol was found to elicit chemopreventive activities ( 49 ). It decreased the total number of aberrant crypt foci in the colons of Wistar rats that were treated with dimethylhydrazine ( 49 ). Under this condition, geraniol reduced DNA damage in the colonic mucosa.…”

Section: The Effects Of Geraniol On Various Types Of Cancermentioning

confidence: 99%

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The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review)

Cho

Chun

et al. 2016

International Journal of Oncology

128

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Geraniol is a dietary monoterpene alcohol that is found in the essential oils of aromatic plants. To date, experimental evidence supports the therapeutic or preventive effects of geraniol on different types of cancer, such as breast, lung, colon, prostate, pancreatic, and hepatic cancer, and has revealed the mechanistic basis for its pharmacological actions. In addition, geraniol sensitizes tumor cells to commonly used chemotherapy agents. Geraniol controls a variety of signaling molecules and pathways that represent tumor hallmarks; these actions of geraniol constrain the ability of tumor cells to acquire adaptive resistance against anticancer drugs. In the present review, we emphasize that geraniol is a promising compound or chemical moiety for the development of a safe and effective multi-targeted anticancer agent. We summarize the current knowledge of the effects of geraniol on target molecules and pathways in cancer cells. Our review provides novel insight into the challenges and perspectives with regard to geraniol research and to its application in future clinical investigation.

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Efficacy of geraniol but not of β-ionone or their combination for the chemoprevention of rat colon carcinogenesis

Cited by 14 publications

References 37 publications

Anticancer Properties of Essential Oils and Other Natural Products

Anticancer Properties of Essential Oils and Other Natural Products

Geraniol, Alone and in Combination with Pioglitazone, Ameliorates Fructose-Induced Metabolic Syndrome in Rats via the Modulation of Both Inflammatory and Oxidative Stress Status

The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review)

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