Automated tumor-feeder detection (AFD) software using cone-beam computed tomography technology is a new tool for three-dimensional vessel tracking. This software is now being used in transarterial targeted therapies, mainly in transarterial chemoembolization for hepatocellular carcinoma, as well as in transarterial embolization and superselective infusion chemotherapy. The detectability rate of the tumor feeder or access route to the target lesions with the AFD software are high in both intrahepatic and extrahepatic lesions. Therefore, the AFD software can reduce the procedural time and radiation exposure, as well as the workload during transarterial targeted therapies.