Efficacy of Automated Tumor-Feeder Detection Software Using Cone-Beam Computed Tomography Technology in Transarterial Targeted Therapy

Miyayama, Shiro; Yamashiro, Masashi; Nagai, Kazuyuki; Tohyama, Jun; Kawamura, Kenshi

doi:10.22575/interventionalradiology.1.1_28

Cited by 4 publications

(6 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Automated tumour-feeder detection software is a new technology using CBCTA data, and its rate of tumour-feeder detection for small HCCs has been reported to be 85-93%. [3][4][5][6][7] It has also been applied to other transarterial targeted therapies, [8][9][10][11][12] including TAE of acute arterial bleeding. 8,9 According to two previous reports, detection of the bleeding point and an access route using CBCTA and AFD was successful in 90-100% of cases, including three cases with obscure bleeding (GI in two and renal in one) on DSA.…”

Section: Discussionmentioning

confidence: 99%

“…Threedimensional (3D) imaging datasets of CBCT during angiography (CBCTA) can also be used for 3D vesseltracking. Automated tumour-feeder detection software (AFD) is a novel tool, and it is now being used in transarterial targeted therapies, [3][4][5][6][7][8][9][10][11][12] mainly in transarterial chemoembolization (TACE) for hepatocellular carcinoma. [3][4][5][6][7] We applied dual-phase CBCTA and AFD to TAE of obscure abdominal arterial bleeding in three cases.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Usefulness of dual‐phase cone‐beam computed tomography during arteriography and automated tumour‐feeder detection software in transarterial embolization for obscure arterial bleeding in the abdomen

et al. 2018

Self Cite

View full text Add to dashboard Cite

We report the usefulness of dual-phase cone-beam computed tomography during angiography (CBCTA) and automated tumour-feeder detection software (AFD) in transarterial embolization (TAE) for three consecutive cases of obscure arterial bleeding in the abdomen. Two patients presented with lower gastrointestinal bleeding and one showed bleeding into the pancreatic pseudocyst. Superior mesenteric or common hepatic angiography did not demonstrate extravasation, but dual-phase CBCTA and AFD could identify extravasation and an access route to the bleeding point. TAE with gelatin sponge particles and a microcoil was successfully performed under AFD guidance in all patients without any complication, and haemostasis could be achieved.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Usefulness of dual‐phase cone‐beam computed tomography during arteriography and automated tumour‐feeder detection software in transarterial embolization for obscure arterial bleeding in the abdomen

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…If curative TACE is expected, a wider safety margin should be created to embolize all potential tumor feeders. If palliative TACE is recommended, the safety margin should be narrower to reduce the adverse effects [90]. In our previous analysis of 155 HCCs ≤5 cm (mean diameter, 17.4 ± 7.4 mm [range, ) including 18 angiographically occult tumors, AFD software using CBCTHA data could detect 85.4% of tumor-feeding subsubsegmental hepatic arteries, 90.3% in new tumors and 75.3% in recurrent tumors.…”

Section: Usefulness Of Ct/cbct and Tace Guidance Softwarementioning

confidence: 99%

“…AFD software can also be useful to identify a tumor feeder arising from extrahepatic arteries and expand the indication and safety of TACE through extrahepatic collaterals. However, if the tumors are fed by the cystic, gastric, or colonic artery, the safety margin should not be included in the target to avoid non-target embolization [90,91].…”

Section: Usefulness Of Ct/cbct and Tace Guidance Softwarementioning

confidence: 99%

Treatment Strategy of Transarterial Chemoembolization for Hepatocellular Carcinoma

Miyayama

2020

Applied Sciences

Self Cite

View full text Add to dashboard Cite

Transarterial chemoembolization (TACE) is a first-line treatment for patients with hepatocellular carcinoma (HCC) in Barcelona Clinic Liver Cancer stage B (BCLC-B). There are two major techniques of TACE: conventional TACE (cTACE) using iodized oil and gelatin sponge particles, and TACE using drug-eluting beads (DEB-TACE). The latest randomized controlled trial proved the superiority of cTACE regarding local effects over DEB-TACE; however, cTACE also damages the liver more severely. Therefore, cTACE should be performed for localized HCCs as selectively as possible. On the other hand, DEB-TACE has less liver toxicity and is favorable for patients with an advanced age, large and/or bilobar tumors, or a poor liver function. However, some BCLC-B HCCs are TACE-resistant and the concept of TACE unsuitability (mainly up-to-7 criteria out) has been proposed by Asia-Pacific Primary Liver Cancer Expert Meeting. Systemic therapy is recommended for patients with TACE-unsuitable HCC; however, the condition of TACE-unsuitable HCC does not always rule out TACE monotherapy and some up-to-7 criteria out tumors may also be good candidates for superselective cTACE when localized in limited liver segments. The sequential therapy of an antiangiogenic and TACE is also a novel option for patients with TACE-unsuitable HCC, antiangiogenic-refractory HCC, or even down-staged HCC.

show abstract

“…Recently, cone-beam computed tomography (CT) (CBCT) and TACE guidance software, including automated tumor feeder detection (AFD) functionality, have been developed and have contributed to improving the technical success rates and therapeutic effects of TACE [ 13 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. We hypothesized that the combination of superselective cTACE and TACE guidance software can achieve sufficient therapeutic effects on small HCC.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Superselective Conventional Transarterial Chemoembolization Using Guidance Software for Hepatocellular Carcinoma within Three Lesions Smaller Than 3 cm

Miyayama

Yamashiro

Ikeda

et al. 2021

Cancers

Self Cite

View full text Add to dashboard Cite

The indication of transarterial chemoembolization (TACE) has advanced to hepatocellular carcinoma (HCC) of Barcelona Clinic Liver Cancer (BCLC) stage A when surgical resection (SR), thermal ablation, and bridging to transplantation are contraindicated; however, TACE for small HCC is frequently difficult and ineffective because of less hypervascularity and the presence of tumor portions receiving a dual blood supply. Here, we report outcomes of superselective conventional TACE (cTACE) for 259 patients with HCCs within three lesions smaller than 3 cm using guidance software. Automated tumor feeder detection (AFD) functionality was applied to identify tumor feeders on cone-beam computed tomography during hepatic arteriography (CBCTHA) data. When it failed, the feeder was identified by manual feeder detection functionality and/or selective angiography and CBCTHA. Regarding the technical success in 382 tumors (mean diameter, 17.2 ± 5.9 mm), 310 (81.2%) were completely embolized with a safety margin (5 mm wide for HCC ≤25 mm and 10 mm wide for HCC >25 mm). In 61 (16.0%), the entire tumor was embolized but the safety margin was not uniformly obtained. The entire tumor was not embolized in 11 (2.9%). Regarding the tumor response at 2–3 months after cTACE in 303 tumors excluding those treated with combined radiofrequency ablation (RFA) or SR and lost to follow-up, 287 (94.7%) were classified into complete response, seven (2.3%) into partial response, and nine (3.0%) into stable disease. The mean follow-up period was 44.9 ± 27.6 months (range, 1–109) and the cumulative local tumor progression rates at 1, 3, 5, and 7 years were 17.8, 27.8, 32.0, and 36.0%, respectively. The 1-, 3-, 5-, and 7-year overall and recurrence-free survival rates in 175 patients, excluding those with Child–Pugh C class, who died of other malignancies, or who underwent combined RFA or hepatic resection, were 97.1 and 68.7, 82.8 and 34.9, 64.8 and 20.2, and 45.3 and 17.3%, respectively. Our results indicate the efficacy of superselective cTACE using guidance software for HCC within three lesions smaller than 3 cm.

show abstract

Efficacy of Automated Tumor-Feeder Detection Software Using Cone-Beam Computed Tomography Technology in Transarterial Targeted Therapy

Cited by 4 publications

References 10 publications

Usefulness of dual‐phase cone‐beam computed tomography during arteriography and automated tumour‐feeder detection software in transarterial embolization for obscure arterial bleeding in the abdomen

Usefulness of dual‐phase cone‐beam computed tomography during arteriography and automated tumour‐feeder detection software in transarterial embolization for obscure arterial bleeding in the abdomen

Treatment Strategy of Transarterial Chemoembolization for Hepatocellular Carcinoma

Efficacy of Superselective Conventional Transarterial Chemoembolization Using Guidance Software for Hepatocellular Carcinoma within Three Lesions Smaller Than 3 cm

Contact Info

Product

Resources

About