Efficacy of Anise (Pimpinella anisum L.) oil for migraine headache: A pilot randomized placebo-controlled clinical trial

Mosavat, Seyed Hamdollah; Jaberi, Abbas Rahimi; Sobhani, Zahra; Mosaffa-Jahromi, Maryam; Iraji, Aida; Moayedfard, Amin

doi:10.1016/j.jep.2019.01.047

Cited by 24 publications

(40 citation statements)

References 20 publications

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“…Anise ( Pimpinella anisum ) is an aromatic plant, and the major components of its essential oil are anethole, eugenol, trans-anethole, methylchavicol, anisaldehyde, umbelliferon, estragole, coumarins, scopoletin, estriols, terpene hydrocarbons, polyenes, and polyacetylenes. Anise has been traditionally used as an analgesic, appetizer, sedative, expectorant, galactagogue, carminative, hepatoprotective, and disinfectant [ 64 , 65 ]. Additionally, it has been suggested that anise could have potential use in relieving early symptoms of COVID-19 because of its efficacy in relieving cough and fever [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Patients’ Behavior Regarding Dietary or Herbal Supplements before and during COVID-19 in Saudi Arabia

Aldwihi

Khan

Alamri

et al. 2021

IJERPH

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The use of traditional medicinal plants in Saudi Arabia stems mainly from consumers’ belief in prophetic medicine. This study was conducted to explore changes in patients’ use of dietary or herbal supplements among individuals infected with COVID-19 before and during infection and the association between herbal or dietary supplements and hospitalization. A cross-sectional, questionnaire-based study was conducted enrolling symptomatic patients who had recently recovered from COVID-19. Data were collected through phone interviews, and McNemar’s test was used to investigate changes to consumption of dietary or herbal supplements before and during infection. Multivariable logistic regression was used to investigate the association between supplements use during patients’ infection and hospitalization. A total of 738 patients were included in this study, of whom 32.1% required hospitalization. About 57% of participants were male with a mean age of 36.5 (±11.9) years. The use of lemon/orange, honey, ginger, vitamin C, and black seed among participants significantly increased during their infection. In contrast, patients using anise, peppermint, and coffee peel before their infection were more likely to stop using them during their infection. In addition, using lemon/orange (p < 0.0001), honey (p = 0.0002), ginger (p = 0.0053), vitamin C (p = 0.0006), black seed (p < 0.0001), peppermint (p = 0.0027), costus (p = 0.0095), and turmeric (p = 0.0012) was significantly higher among nonhospitalized patients than hospitalized ones. However, in the multivariable logistic regression, only use of vitamin C (OR = 0.51; 95% CI 0.33–0.79), peppermint (OR = 0.53; 95% CI 0.31–0.90), and lemon/orange (OR = 0.54; 95% CI 0.33–0.88) was associated with significantly lower odds of hospitalization. The study reveals that patients’ consumption of dietary or herbal supplements changed in response to their COVID-19 infection, with hospitalized patients having a lower likelihood of using these supplements. Because some supplements were associated with lower odds of hospitalization, these supplements or their bioactive components should be further investigated as feasible options for COVID-19 treatment.

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Section: Discussionmentioning

confidence: 99%

Patients’ Behavior Regarding Dietary or Herbal Supplements before and during COVID-19 in Saudi Arabia

Aldwihi

Khan

Alamri

et al. 2021

IJERPH

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“…Pimpinella anisum , also known as anise, contains an active compound with both estrogenic and analgesic, antioxidant, antimicrobial, anticonvulsant, and antispastic properties [110,111]. Moreover, anise exerts activity on the gastrointestinal system with an antiulcer action while the aromatic effects have been demonstrated in the palliation of nausea [110,112]. The primary therapeutic target in menopause is against hot flashes [111].…”

Section: Herbal Derivativesmentioning

confidence: 99%

A Nutraceutical Approach to Menopausal Complaints

et al. 2019

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The menopausal transition, or perimenopause, is characterized by menstrual irregularities, vasomotor symptoms, sleep disturbances, mood symptoms, and urogenital tract atrophy. These changes can also affect the quality of life and one’s self-esteem. Hormone replacement therapy (HRT) is considered the best option to achieve therapeutic relief of different menopausal symptoms but is usually restricted to moderate or severe symptoms. Moreover, many women refuse HRT for a variety of reasons concerning the fear of cancer and other adverse effects. According to these considerations, new topics are emerging: Dissatisfaction with drug costs and conventional healthcare, desire for personalized medicines, and the public perception that “natural is good”. In this context, nonhormonal therapies are mostly evolving, and it is not unusual that women often request a “natural” approach for their symptoms. The aim of this study is to investigate nonhormonal therapies that have been identified to reduce the menopausal symptoms.

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“…Currently, growing attention is paid to complementary and alternative medicine in management of chronic diseases. [12][13][14][15][16][17][18][19] Moreover, todays some foods are known as complementary therapies in some diseases. 20,21 Whey protein is one of the major types of milk proteins that is derived from milk during the production process of cheese and considered as a functional food.…”

Section: Introductionmentioning

confidence: 99%

“…Currently, growing attention is paid to complementary and alternative medicine in management of chronic diseases 12‐19 . Moreover, todays some foods are known as complementary therapies in some diseases 20,21 .…”

Section: Introductionmentioning

confidence: 99%

Efficacy of oral supplementation of whey protein in patients with contact dermatitis: A pilot randomized double‐blind placebo‐controlled clinical trial

Alyasin

Nabavizadeh

Esmaeilzadeh

et al. 2020

Dermatologic Therapy

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Whey protein is a popular dietary product that has numerous health benefits such as immune modulation. In this study, we assessed efficacy of whey protein in management of patients with contact dermatitis (CD) through a double blind, randomized controlled clinical trial in Emam Reza clinic, Shiraz, Iran. Twenty-five patients in each group were randomly assigned to receive whey protein or placebo powder, 30 g in 200 mL warm water at fasting time for 4 weeks. Outcome measures were Dermatology Life Quality Index (DLQI) questionnaire and the Eczema Area and Severity Index (EASI) score. Furthermore, subjective total improvement (assessed by visual analogue scale) was set as the other primary outcome measure. A significant decrease was observed in the scores of EASI, DLQI, and subjective total improvement in the drug group after the intervention compared with the baseline. However, no changes were seen in the placebo group. Moreover, there was a significant reduction in the scores of EASI (P = .002) and subjective total improvement scores (P = .039) over the study period in the drug group compared with the placebo group. According to the results of this study, it seems that oral supplementation of whey protein could improve the symptoms of CD compared with placebo.

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Efficacy of Anise (Pimpinella anisum L.) oil for migraine headache: A pilot randomized placebo-controlled clinical trial

Cited by 24 publications

References 20 publications

Patients’ Behavior Regarding Dietary or Herbal Supplements before and during COVID-19 in Saudi Arabia

Patients’ Behavior Regarding Dietary or Herbal Supplements before and during COVID-19 in Saudi Arabia

A Nutraceutical Approach to Menopausal Complaints

Efficacy of oral supplementation of whey protein in patients with contact dermatitis: A pilot randomized double‐blind placebo‐controlled clinical trial

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