Efficacy of an oral antihistamine, astemizole, as compared to a nasal steroid spray in hay fever

Abstract

The efficacy and side effects of the oral H,-antihistamine, astemizole, were compared with those of nasal beclomethasone in 158 adult birch-pollen allergic hay fever patients. 148 patients eompleted the 5-week, controlled trial which took place in Stockholm, May 1986, during the birch pollen season. Daily pollen counts were found to be at a rather low level throughout the study period. The effeet and tolerability of both drugs were found to be excellent, although beelomethasone reduced nasal symptoms (sneezing, rhlnorrhoea, blocked nose) significantly more effectively than astemizole. Eye symptoms were mild and equal in both groups. The results indicate that oral astemizole is an effective non-sedating antihistamine, though less so than nasal beclomethasone, in the treatment of nasal hay fever symptoms.

Utilisation of the Prestwick Chemical Library to identify drugs that inhibit the growth of mycobacteria

“…Astemizole had the lowest MIC value of 17.8μM within this group followed by tripelennamine, with an MIC of 41.9μM and olopatadine with the highest MIC value of 202.3 μM in (Table 3). Astemizole (used for general allergies, asthma and rhinitis), tripelennamine (hay fever and rhinitis) and olopatadine (allergic conjunctivitis) are mildly anti-cholinergic and act as H1 receptor antagonists [21–24]. Of the antidiabetic drugs displaying activity towards BCG, glipizide and rosiglitazone have an MIC value of 191.1 μM and 43.15 μM, respectively (Table 3).…”

“…Analysis of the M . smegmatis meclocyline sulfosalicylate mutant revealed a synonymous single nucleotide polymorphism (SNPs) mutation in the gene MSMEG_3619 ( Mtb ortholog Rv1856c), a probable oxidoreductase deemed non-essential by the Himar-I based transposon mutagenesis [21], but also showing importance as having a growth advantage which results in an improvement in fitness when disrupted [32]. A single SNP (P122S) was also observed in MSMEG_5249 ( Mtb ortholog Rv1093) glyA1 which is a serine hydroxymethyltransferase with possible roles of glycine to serine inter-conversion and the generation of 5, 10-methyenetetrahydrofolate which plays an important role in providing precursors for cellular redox balancing, methylation reactions and a role in thymidylate biosynthesis (Table 5).…”