Comparison of Intranasal Corticosteroids and Antihistamines in Allergic Rhinitis

Nielsen, Lars Peter; Dahl, Ronald

doi:10.1007/bf03256639

Cited by 47 publications

(32 citation statements)

References 125 publications

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“…In addition, we excluded patients who had used corticosteroids intranasally in the 4 weeks before enrolment. Based on the current evidence of the efficacy of intranasal corticosteroid treatment in allergic rhinitis, 33 patients with acute rhinosinusitis who have this underlying condition may benefit from corticosteroids. Future research is needed to determine the efficacy of corticosteroid treatment in these subgroups of patients.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Systemic corticosteroid monotherapy for clinically diagnosed acute rhinosinusitis: a randomized controlled trial

Venekamp

Bonten

Rovers

et al. 2012

CMAJ

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Section: Strengths and Limitationsmentioning

confidence: 99%

Systemic corticosteroid monotherapy for clinically diagnosed acute rhinosinusitis: a randomized controlled trial

Venekamp

Bonten

Rovers

et al. 2012

CMAJ

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“…Second generation AHs are usually effective against sneezing and rhinorrhea through H 1 receptor blockade but are less effective against nasal congestion, which is induced by mediators other than histamine5,24. LCTZ is a potent anti-allergic drug, classified as a second-generation antihistamine, with an early onset of action and a long duration of effects on the symptoms of AR25.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of fluticasone furoate nasal spray and levocetirizine in patients with Japanese cedar pollinosis subjected to an artificial exposure chamber

Hashiguchi

Kanzaki

Wakabayashi

et al. 2013

Journal of Drug Assessment

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ObjectiveThis study investigated the clinical efficacy of a combination therapy of levocetirizine (LCTZ) and fluticasone furoate nasal spray (FFNS), compared with LCTZ monotherapy, for the suppression of seasonal allergic rhinitis (SAR) symptoms induced in an artificial exposure chamber.MethodsThis study was a single-center, placebo-controlled, randomized, 3-way cross-over comparative study performed in 42 Japanese cedar pollinosis patients. These subjects received (1) LCTZ plus FFNS (combination group), (2) LCTZ plus FFNS placebo (monotherapy group), or (3) LCTZ placebo plus FFNS placebo (placebo group) once on the night prior to exposure, with a 1-week washout period between exposures. Nasal (sneezing, rhinorrhea, nasal congestion, and itchy nose) and ocular (eye itching and tearing) symptoms were recorded every 15 min, and the number of sneezes, nose blowing events, and the amount of nasal secretions were measured during exposure. The primary end-point was the cumulative incidence of SAR symptoms during exposure and the ‘ime to occurrence of symptoms’. The secondary end-points were the total nasal symptom score, the ocular symptom score, the amount of nasal discharge, and the number of sneezes and nose blowing events.ResultsAt all the measurement points, the lowest cumulative incidences for the nasal symptoms were observed in the combination group, followed by the monotherapy and placebo groups. All the subjects in the placebo group developed nasal symptoms within 2 h after pollen exposure, while three and eight subjects in the monotherapy and combination groups, respectively, did not develop any nasal symptoms during exposure. In addition, combination therapy delayed the onset of symptoms.ConclusionsThe results demonstrated that combination therapy with FFNS and LCTZ significantly suppressed the induced SAR symptoms and delayed the onset of symptoms compared with LCTZ monotherapy and placebo. Although the conditions of the allergen challenge study using an exposure chamber are different from those in real life, combination therapy with FF and LCTZ was confirmed to be an effective treatment for SAR.

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“…Antihistamines also do not seem to be superior in the treatment of conjunctivitis associated with AR (Nielsen & Dahl, 2003).…”

Section: Side Effects Safety and Tolerance Of Glucocorticosteroidsmentioning

confidence: 97%

Treatment of Allergic Rhinitis: Anticholinergics, Glucocorticotherapy, Leukotriene Antagonists, Omalizumab and Specific-Allergen Immunotherapy

Palomo¹,

Bobolea²,

Gonzalez³

et al. 2012

Otolaryngology

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Comparison of Intranasal Corticosteroids and Antihistamines in Allergic Rhinitis

Cited by 47 publications

References 125 publications

Systemic corticosteroid monotherapy for clinically diagnosed acute rhinosinusitis: a randomized controlled trial

Systemic corticosteroid monotherapy for clinically diagnosed acute rhinosinusitis: a randomized controlled trial

Efficacy of fluticasone furoate nasal spray and levocetirizine in patients with Japanese cedar pollinosis subjected to an artificial exposure chamber

Treatment of Allergic Rhinitis: Anticholinergics, Glucocorticotherapy, Leukotriene Antagonists, Omalizumab and Specific-Allergen Immunotherapy

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