Efficacy of adjunctive photodynamic therapy on the clinical periodontal, HbA1c and advanced glycation end product levels among mild to moderate chronic periodontal disease patients with type 2 diabetes mellitus: A randomized controlled clinical trial

Mirza, Sana; Khan, Aftab Ahmed; Al‐Kheraif, Abdulaziz A.; Khan, Sultan Zeb; Shafqat, Syed Saad

doi:10.1016/j.pdpdt.2019.08.003

Cited by 34 publications

(8 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They cause cellular damage by modifying protein function and cellular interaction with the extracellular membrane, alter the intracellular Ca 2+ concentration and mitochondrial function, deregulate the inflammatory response, influence wound repair, and increase oxidative stress through the connection with its receptors, RAGE [6,66]. It has been suggested that high levels of AGEs may modify collagen structure, making the periodontal tissues less soluble with less reparative tendency, and along with other altered cellular responses, making them more susceptible to periodontal breakdown [67].…”

Section: Mitochondrial Dysfunctionmentioning

confidence: 99%

Diabetes Mellitus and Periodontitis Share Intracellular Disorders as the Main Meeting Point

Portes

Bullón

Quiles

et al. 2021

Cells

View full text Add to dashboard Cite

Diabetes and periodontitis are two of the most prevalent diseases worldwide that negatively impact the quality of life of the individual suffering from them. They are part of the chronic inflammatory disease group or, as recently mentioned, non-communicable diseases, with inflammation being the meeting point among them. Inflammation hitherto includes vascular and tissue changes, but new technologies provide data at the intracellular level that could explain how the cells respond to the aggression more clearly. This review aims to emphasize the molecular pathophysiological mechanisms in patients with type 2 diabetes mellitus and periodontitis, which are marked by different impaired central regulators including mitochondrial dysfunction, impaired immune system and autophagy pathways, oxidative stress, and the crosstalk between adenosine monophosphate-activated protein kinase (AMPK) and the renin-angiotensin system (RAS). All of them are the shared background behind both diseases that could explain its relationship. These should be taken in consideration if we would like to improve the treatment outcomes. Currently, the main treatment strategies in diabetes try to reduce glycemia index as the most important aspect, and in periodontitis try to reduce the presence of oral bacteria. We propose to add to the therapeutic guidelines the handling of all the intracellular disorders to try to obtain better treatment success.

show abstract

Section: Mitochondrial Dysfunctionmentioning

confidence: 99%

Diabetes Mellitus and Periodontitis Share Intracellular Disorders as the Main Meeting Point

Portes

Bullón

Quiles

et al. 2021

Cells

View full text Add to dashboard Cite

show abstract

“…In chronic hyperglycemic conditions, glycosylation of several proteins produces advanced glycemic end (AGE) products that cross-link with collagen fibers leading to a decrease in their reparative tendency, aggravate the periodontal disease, and increase complications. 14 Surprisingly, more than 59% of the practitioners were unaware of this fact. This result again reflects the need for regular training and continuing medical educations (CME) to update knowledge of dentists of Nepal.…”

Section: Discussionmentioning

confidence: 99%

Knowledge, Attitude and Practice Related to Diabetes Mellitus in Dentists of Nepal

Joshi

Pokhrel

Shrestha³

et al. 2022

JCMC

View full text Add to dashboard Cite

Background: Diabetes mellitus (DM) is one of the most common systemic diseases encountered by dentists in daily practice. The present study aimed to assess the knowledge, attitude, and practice of dentists regarding diabetes mellitus. Methods: This cross-sectional study was conducted among the dentists of Nepal from August to December 2020. A total of 345 dentists throughout the country took part in this study. A set of 27 self-designed questions was used as the study tool, among which 11 questions were about knowledge, seven were about attitude, and nine were about practice related to DM. The result was expressed in frequency and percentage. Chi square and Spearman’s correlation analysis were performed with SPSS version 16. Results: The mean knowledge score was 8.15 ± 1.54 with 11 being the highest possible score. Of the total participants, 252 (73%) had good knowledge regarding DM. The mean attitude score was 4.68 ±1.19, where seven was the highest possible score. Of the total respondents, only 190 (55.1%) had a positive attitude. The mean practice score was 7.19 ± 1.19, with nine being the highest possible score. A majority of the respondents (N = 320, 92.8%) had good practice habits regarding diabetic patients. Correlation analysis showed a weak positive but significant correlation among knowledge, attitude, and practice. Conclusions: There was good knowledge and practice in dentists though there were frequent areas of improvement in attitude. Various trainings like continuing medical educations (CME) may be beneficial to improve personal beliefs.

show abstract

“…One of its causes may be the resistance of the insulin present in the body or the reduction in the amount of insulin produced (type 2 DM). Another manifestation of this disease occurs when the insulin-producing cells (pancreatic β) are destroyed, hindering hormone secretion (type 1 DM) 2,3 .…”

Section: Introductionmentioning

confidence: 99%

“…As the illness progresses, it may trigger disorders such as nephropathy, neuropathy, retinopathy (microvascular complications), coronary heart disease, peripheral vascular disease and heart failure (macrovascular complications) 1,3,4 .…”

Section: Introductionmentioning

confidence: 99%

Coffee intake (Coffea arabica L.) reduces advanced glycation end product (AGEs) formation and platelet aggregation in diabetic rats

Silvério

Pereira

Duarte

et al. 2021

Rev. Ciênc. Farm. Básica Apl.

View full text Add to dashboard Cite

Objectives:The study aimed to determine the effect of coffee intake on AGEs formation and platelet aggregation in diabetic Wistar rats. Methods: Coffee powder samples were used to prepare a 10% beverage. Diabetes mellitus was induced in the animals by administering 2% alloxan. All animal experiments were approved by the ethics committee for animal experiments under N°. 420/2012 and 536/2013. Diabetic and non-diabetic rats were divided into 6 groups treated and untreated with coffee (7.2 mL/Kg body weight) and aminoguanidine (AGE inhibiting agent) (100 mg/Kg body weight) for 50 days. After 50 days, the animals were fasted for 12 h and anesthetized (40 mg/Kg sodium pentobarbital) intraperitoneally. Blood samples were collected from the abdominal artery puncture. Hematological parameters (red cells, hemoglobin, hematocrit and leukocyte) and glycemic and HbA1c levels were measured. AGEs quantification (spectrofluorometric method) and the platelet aggregation test (aggregation of cuvettes in a fourchannel platelet aggregometer) were also conducted. The rats' renal function was evaluated by measuring serum urea and creatinine. Results: Data showed that coffee intake had no effect on the hematological parameters. Fasting glucose and HbA1c dosage were significantly higher in diabetic animals compared to non-diabetic animals (confirmed the effectiveness of inducing and maintaining diabetic status). Results showed that coffee reduced AGE formation and platelet aggregation in our animal model, not altering the animals' renal function. Conclusions: These results suggest beneficial effects on vasculopathy, a common complication in diabetic patients.

show abstract

Efficacy of adjunctive photodynamic therapy on the clinical periodontal, HbA1c and advanced glycation end product levels among mild to moderate chronic periodontal disease patients with type 2 diabetes mellitus: A randomized controlled clinical trial

Cited by 34 publications

References 27 publications

Diabetes Mellitus and Periodontitis Share Intracellular Disorders as the Main Meeting Point

Diabetes Mellitus and Periodontitis Share Intracellular Disorders as the Main Meeting Point

Knowledge, Attitude and Practice Related to Diabetes Mellitus in Dentists of Nepal

Coffee intake (Coffea arabica L.) reduces advanced glycation end product (AGEs) formation and platelet aggregation in diabetic rats

Contact Info

Product

Resources

About