Efficacy of adjunctive anti‐plaque chemical agents: a systematic review and network meta‐analyses of the Turesky modification of the Quigley and Hein plaque index

Escribano, M. Isabel; Figuero, Elena; Martín, Conchita; Tobías, Aurelio; Serrano, J. A.; Roldán, Silvia; Herrera, David

doi:10.1111/jcpe.12616

Cited by 57 publications

(92 citation statements)

References 69 publications

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“…However, in the present study, the individuals in the periodontitis group underwent full-mouth scaling plus CHX, as described by Quirynen et al 25 , instead of EO. Despite some undesirable side effects due to its higher anti-plaque effectiveness, CHX is the first option for the short-term chemical dental biofilm control of periodontitis 14,[26][27][28][29] . Thus, whether a longer period of time is needed to observe the total protein level reduction in the presence of periodontitis is a subject for further studies, especially when considering the improvements in the classical clinical parameters.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, this group received oral hygiene instructions and rinsed with an EO mouthwash, which, according to Raslan et al 13 , provided additional benefits when compared to isolated mechanical procedures. Studies that have compared EOs with CHX demonstrated that EOs are a viable option for gingivitis patients due to their appropriate clinical benefits with less side effects 14,[26][27][28][29] . The present gingivitis patients showed statistically significant improvements at 3 months, as revealed by the PD, PI, and GI reductions.…”

Section: Discussionmentioning

confidence: 99%

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Salivary arginase activity after mechanical-chemical therapy

Castro

Cortelli

Rodrigues

et al. 2018

Rev. odontol. UNESP

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ResumoIntrodução: Componentes salivares podem ser usados como biomarcadores para diagnóstico e monitoramento de doenças orais. Há evidências de que um potencial biomarcador, arginase, está associado com os processos inflamatórios da doença periodontal, e após o tratamento sua atividade enzimática é reduzida em concordância com a melhora nos parâmetros clínicos. Objetivo: O presente estudo objetivou avaliar a atividade da arginase salivar em pacientes com gengivite e periodontite tratados com procedimentos mecânicos em estágio único combinados ao uso coadjuvante de enxaguatórios com óleos essenciais ou clorexidina, respectivamente. Material e método: Vinte e seis pacientes com gengivite e 16 pacientes com periodontite receberam exame periodontal completo antes e 3 meses após a terapia, em que mensurações de profundidade de sondagem, perda de inserção clínica, índice de placa e índice gengival foram realizadas. Nestas mesmas consultas os níveis de proteína total e a atividade de arginase salivar foram estabelecidos via espectrofotometria. Resultado: Todos os parâmetros clínicos melhoraram, em ambos os grupos, do exame inicial para o de 3 meses (p < 0,05). Adicionalmente, após tratamento para gengivite houve redução da atividade de arginase salivar e do nível de proteína total. Conclusão: Semelhante aos resultados clínicos, ambos os protocolos terapêuticos afetaram positivamente a atividade da arginase salivar; entretanto, estudos futuros são necessários para clarificar seu potencial como biomarcador salivar para o monitoramento periodontal. AbstractIntroduction: Salivary components can be used as biomarkers for diagnosing and monitoring oral diseases. There is evidence that one potential biomarker, arginase, is associated with the inflammatory processes of periodontal disease, and its enzymatic activity is reduced according to the improvement in the clinical parameters after treatment. Objective: The present study aimed to evaluate the salivary arginase activity in gingivitis and periodontitis patients treated with full-mouth mechanical procedures combined with the adjunctive use of essential oils or chlorhexidine mouthwash, respectively. Material and method: Twenty-six gingivitis and 16 periodontitis patients received complete periodontal examinations at the baseline and 3 months after therapy, in which the periodontal probing depth, clinical attachment loss, plaque index, and gingival index measurements were taken. At these same appointments, the salivary total protein level and salivary arginase activity were also established via spectrophotometry. Result: There were improvements in all of the clinical parameters (p < 0.05) evaluated from the baseline to 3 months in both groups. In addition, the salivary arginase activity and total protein levels were reduced after the gingivitis treatment. Conclusion: Similar to the clinical results, both therapeutic protocols positively affected the salivary arginase activity; however, further studies are necessary to clarify its potential as a salivary biomarker for periodont...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Salivary arginase activity after mechanical-chemical therapy

Castro

Cortelli

Rodrigues

et al. 2018

Rev. odontol. UNESP

View full text Add to dashboard Cite

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“…A possible reason to explain the discrepancy between both reviews could be that, in the previous one, only two studies assessing the outcomes of interest were included . Nevertheless, when these products have been evaluated for the reduction of plaque and gingivitis indices during a 6‐month period, two recent systematic reviews have failed to support an added value …”

Section: Discussionmentioning

confidence: 99%

Changes in plaque and gingivitis levels after tooth bleaching: A systematic review

Sanz‐Sánchez

Oteo‐Calatayud

Serrano

et al. 2019

Int J Dental Hygiene

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Objectives The primary aim of this systematic review was to evaluate the effect of external tooth‐bleaching products on plaque indices and to compare it to a placebo or a negative control. Methods A protocol was developed aimed to answer the next focused question: What is the effect of tooth bleaching compared to no treatment or a placebo, in subjects without periodontitis aged ≥18 years in the levels of plaque and gingivitis? Two electronic databases were used as sources in the search for studies satisfying the inclusion criteria: (a) The National Library of Medicine (MEDLINE via PubMed); (b) Cochrane Central Register of Controlled Trials. Results Only randomized controlled trials were included. The initial search found 382 potential publications. Seven of them were finally included, and six were used in the meta‐analyses. The use of bleaching products showed higher reductions in plaque (n = 6; standardized mean difference [SMD] = 0.47; 95% confidence interval [CI] = 0.06, 0.88; P < 0.001) and gingivitis indices (n = 4; SMD = 0.47; 95% CI = 0.22, 0.73; P < 0.001), when compared to a control group (no treatment or placebo). Conclusions External tooth bleaching is associated with statistically significant short‐term reductions in plaque and gingivitis indices. However, no data were available to evaluate long‐term effects.

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“…The dentifrices without BS were separated into negative and positive controls. As a positive control, dentifrices containing stannous fluoride (SnF) or triclosan (Tcs) as ingredients were considered . All the other dentifrices without BS were considered as negative controls.…”

Section: Methodsmentioning

confidence: 99%

The efficacy of baking soda dentifrice in controlling plaque and gingivitis: A systematic review

Valkenburg

Kashmour

Dao

et al. 2019

Int J Dental Hygiene

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Objective To test the efficacy of a dentifrice containing baking soda (BS), compared with dentifrice without BS for controlling plaque and gingivitis. Materials and methods MEDLINE‐PubMed and Cochrane‐CENTRAL were searched. The inclusion criteria were randomized controlled clinical trials including healthy participants aged 18 years or older. Studies were selected that compared the effect of toothbrushing with a dentifrice with and without BS on the clinical parameters of plaque and gingivitis. Data were extracted from the selected studies, and a meta‐analysis was performed. Results The search retrieved 21 eligible publications. Among these papers, 43 comparisons were provided, with 23 involving a single‐use design and 20 being evaluations with a follow‐up. Negative controls were found, or positive controls for which various active ingredients had been used. The included studies showed a moderate overall potential risk of bias and considerable heterogeneity. The meta‐analysis of plaque scores from the single‐brushing experiments showed that BS dentifrice (BS‐DF) was associated with significantly better outcomes than the negative control dentifrices (DiffM −0.20; P < 0.0001; 95% CI: [−0.27; −0.12]) or the positive control dentifrices (DiffM −0.18; P < 0.0001; 95% CI: [−0.24; −0.12]). This finding was only confirmed in studies that used a follow‐up design as compared to a negative control (DiffM −0.19; P = 0.01; 95% CI: [−0.34; −0.04]). The indices of gingival bleeding also improved when the comparison was a negative control (DiffM −0.08; P = 0.02; 95% CI: [−0.16; −0.01] and (DiffM −0.13; P < 0.001; 95% CI: [−0.18; −0.08]. However, for the gingival index scores, the meta‐analysis did not reveal any significant differences. Conclusion BS‐DF showed promising results with respect to plaque removal in single‐use studies. However, the finding was partially substantiated in follow‐up studies. Studies that assessed bleeding scores indicated that a small reduction can be expected from BS, relative to a control product.

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Efficacy of adjunctive anti‐plaque chemical agents: a systematic review and network meta‐analyses of the Turesky modification of the Quigley and Hein plaque index

Abstract: Within the limitations of this study (including the severe imbalance in the amount of evidence), dentifrices containing triclosan-copolymer or chlorhexidine and mouthrinses containing essential oils or chlorhexidine showed the greatest effect on PlI scores as assessed with NMA.

Cited by 57 publications

References 69 publications

Salivary arginase activity after mechanical-chemical therapy

Salivary arginase activity after mechanical-chemical therapy

Changes in plaque and gingivitis levels after tooth bleaching: A systematic review

The efficacy of baking soda dentifrice in controlling plaque and gingivitis: A systematic review

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