Efficacy of Adiantum capillus veneris Linn in chemically induced urolithiasis in rats

Ahmed, Ajij; Wadud, Abdul; Jahan, Nasreen; Bilal, Alia; Hajera, Syeda

doi:10.1016/j.jep.2013.01.011

Cited by 46 publications

(25 citation statements)

References 8 publications

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“…The extracts of the leaves have strong anti-microbial activities (Singh et al, 2008; Reinaldo et al, 2015). The hydro-alcoholic extract of leaves has strong anti-urolithic properties that are usually claimed (Ahmed et al, 2013). Among the medicinal properties of Adiantum leaves, anti-inflammatory and analgesic effects (Haider et al, 2011) are driving the attention of phytochemists to look for other chemical constituents that might be of the potential biological interest.…”

Section: Introductionmentioning

confidence: 99%

Reversed Phase HPLC-DAD Profiling of Carotenoids, Chlorophylls and Phenolic Compounds in Adiantum capillus-veneris Leaves

Zeb

Ullah

2017

Front. Chem.

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Adiantum capillus-veneris is important endangered fern species with several medicinal properties. In this study, the leaves samples were extracted and separated using reversed phase HPLC with DAD for carotenoids, chlorophylls and phenolic compounds. Separation of carotenoids and chlorophylls were carried out using a tertiary gradient system of water, MTBE and methanol-water, while a binary gradient system of methanol-water-acetic acid was used for phenolic profiling. Results revealed eight carotenoids, four pheophytins, and two chlorophylls. Lutein (806.0 μg/g), chlorophyll b′ (410.0 μg/g), chlorophyll a (162.4 μg/g), 9′-Z-neoxanthin (142.8 μg/g) and all-E-violaxanthin (82.2 μg/g) were present in higher amounts. The relatively high amounts of lutein may be one of the key indicator of beneficial antioxidant properties. The phenolic profile revealed a total of 13 compounds, namely 4-hydroxybenzoic acid, chlorogenic acid, caftaric acid, kaempferol glycosides, p-coumaric acid, rosmarinic acid, 5-caffeoylquinic acid, and quercetin glycosides. Kaempferol-3-sophorotrioside (58.7 mg/g), chlorogenic acid (28.5 mg/g), 5-O-caffeoylquinic acid (18.7 mg/g), coumaric acid (11.2 mg/g), and its derivative (33.1 mg/g) were present in high amounts. These results suggest that the reversed phase HPLC profiling of Adiantum leaves provides a better understanding in to the actual composition of bioactive compounds, which may be responsible for the potential medicinal properties. Adiantum leaves rich in important bioactive phytochemicals can be used as a possible source of nutraceuticals or as a functional food ingredient.

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Section: Introductionmentioning

confidence: 99%

Reversed Phase HPLC-DAD Profiling of Carotenoids, Chlorophylls and Phenolic Compounds in Adiantum capillus-veneris Leaves

Zeb

Ullah

2017

Front. Chem.

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“…Many medicinal plants are used to treat urolithiasis worldwide [17, 22, 23]. Plants provide an inexpensive source of medicine for the majority of the world's population, and such medicines are considered safe and present minimal or no side effects [24].…”

Section: Discussionmentioning

confidence: 99%

An Explanation of the Underlying Mechanisms for the In Vitro and In Vivo Antiurolithic Activity of Glechoma longituba

Liang

Zhou

et al. 2016

Oxidative Medicine and Cellular Longevity

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Purpose. To use in vitro and in vivo models to evaluate Glechoma longituba extract to provide scientific evidence for this extract's antiurolithic activity. Materials and Methods. Potassium citrate was used as a positive control group. Oxidative stress (OS) markers and the expression of osteopontin (OPN) and kidney injury molecule-1 (KIM-1) were measured to assess the protective effects of Glechoma longituba. Multiple urolithiasis-related biochemical parameters were evaluated in urine and serum. Kidneys were harvested for histological examination and the assessment of crystal deposits. Results. In vitro and in vivo experiments demonstrated that treatment with Glechoma longituba extract significantly decreased calcium oxalate- (CaOx-) induced OPN expression, KIM-1 expression, and OS compared with the positive control group (P < 0.05). Additionally, in vivo rats that received Glechoma longituba extract exhibited significantly decreased CaOx deposits and pathological alterations (P < 0.05) compared with urolithic rats. Significantly lower levels of oxalate, creatinine, and urea and increased citrate levels were observed among rats that received Glechoma longituba (P < 0.05) compared with urolithic rats. Conclusion. Glechoma longituba has antiurolithic effects due to its possible combined effects of increasing antioxidant levels, decreasing urinary stone-forming constituents and urolithiasis-related protein expression, and elevating urinary citrate levels.

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“…Antioxidant supplement can protect kidney tubules cell membrane, thus leading to prevent stone formation (Th amilselvan et al 1997). Flavonoids compounds with lowering urinary citrate and increasing oxalate contribute to the prevention of calcium oxalate stones formation, and it is partly relevant to anti-infl ammatory and antioxidant eff ects of fl avonoids (Ahmed et al 2013). Daily intake of 400 IU VitE for 60 days increased urinary citrate with increasing plasma levels of alpha-tocopherol, which is a key factor in the prevention of kidney stones (Th eka et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Protective effects of boron and vitamin E on ethylene glycol-induced renal crystal calcium deposition in rat

Bahadoran

Naghii

Mofid

et al. 2016

Endocrine Regulations

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Efficacy of Adiantum capillus veneris Linn in chemically induced urolithiasis in rats

Cited by 46 publications

References 8 publications

Reversed Phase HPLC-DAD Profiling of Carotenoids, Chlorophylls and Phenolic Compounds in Adiantum capillus-veneris Leaves

Reversed Phase HPLC-DAD Profiling of Carotenoids, Chlorophylls and Phenolic Compounds in Adiantum capillus-veneris Leaves

An Explanation of the Underlying Mechanisms for the In Vitro and In Vivo Antiurolithic Activity of Glechoma longituba

Protective effects of boron and vitamin E on ethylene glycol-induced renal crystal calcium deposition in rat

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