Efficacy of Acupuncture for Parkinson’s Disease Anxiety: Two-Stage Protocol for a Randomized Controlled Clinical Trial

Fan, Jing-Qi; Xu, Zi-Qiao; Chen, Yuanyuan; Lu, Wei-Jing; Xie, Xiaoyan; Wang, Yuting; Zhuang, Li-Xing

doi:10.1155/2022/5180193

Cited by 2 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was registered (ChiCTR2100047253) before inclusion of the first participant and its protocol has been publicly available. 3 …”

Section: Methodsmentioning

confidence: 99%

“…This study followed the Consolidated Standards of Reporting Trials (CONSORT) reporting guideline and the Standards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA) guideline for the designing and reporting of this trial. It was registered (ChiCTR2100047253) before inclusion of the first participant and its protocol has been publicly available …”

Section: Methodsmentioning

confidence: 99%

“… 2 Treatment, etiology, or symptoms of PD make anxiety a natural outcome (eFigure 1 in Supplement 2 ). 3 Patients with PD and anxiety show greater disability and poorer wellbeing than these patients without anxiety. 4 Moreover, disturbances in gait and freezing of gait have been reported to be associated with anxiety symptoms.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effectiveness of Acupuncture for Anxiety Among Patients With Parkinson Disease

Fan

Tan

et al. 2022

JAMA Netw Open

Self Cite

View full text Add to dashboard Cite

ImportanceOne of the ordinary manifestations of Parkinson disease (PD) is anxiety, which remains untreated. Anxiety is closely associated with the accelerated progression of PD. Efficacy of acupuncture for anxiety has been reported. However, to date, there are no data on acupuncture’s effectiveness on anxiety for patients with PD.ObjectiveTo investigate the effect of acupuncture vs sham acupuncture for treating anxiety in patients with PD.Design, Setting, and ParticipantsThis is randomized, double-blinded, clinical trial enrolled patients between June 20, 2021, and February 26, 2022. Final follow-up was April 15, 2022. Patients with Parkinson disease and anxiety were allocated randomly (1:1) to receive acupuncture or sham acupuncture for 8 weeks. Acupuncture operators, outcome measures evaluators, and statistical analysts were blinded to the grouping of patients. Patients were blinded to their own grouping during the study. This study took place in the Parkinson clinic of a hospital in China.InterventionsReal acupuncture or sham acupuncture for 8 weeks.Main Outcomes and MeasuresPrimary outcome was Hamilton Anxiety Scale (HAM-A) score. Secondary outcomes were scores on the Unified Parkinson Disease Rating Scale (UPDRS), 39-item Parkinson Disease Questionnaire (PDQ-39), and serum levels of the adrenocorticotropic hormone (ACTH) and cortisol (CORT).ResultsSeventy eligible patients were enrolled, including 34 women (48.5%) and 36 men (51.4%). Sixty-four patients (91%) completed the intervention and the 8-week follow-up, including 30 women (46.9%) and 34 men (53.1%) with a mean (SD) age of 61.84 (8.47) years. At the end of treatment, the variation of HAM-A score was 0.22 (95% CI, –0.63 to 1.07; P = .62) between the real acupuncture and sham acupuncture groups. At the end of follow-up, the real acupuncture group had a significant 7.03-point greater (95% CI, 6.18 to 7.88; P < .001) reduction in HAM-A score compared with the sham acupuncture group. Four mild adverse reactions occurred during the study.Conclusions and RelevanceThis study found acupuncture to be an effective treatment for anxiety in patients with PD. These findings suggest that acupuncture may enhance the wellbeing of patients who have Parkinson disease and anxiety.Trial RegistrationChinese Clinical Trial Registry: ChiCTR2100047253

show abstract

“…It was registered (ChiCTR2100047253) before inclusion of the first participant and its protocol has been publicly available. 3 …”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Effectiveness of Acupuncture for Anxiety Among Patients With Parkinson Disease

Fan

Tan

et al. 2022

JAMA Netw Open

Self Cite

View full text Add to dashboard Cite

show abstract

“…Acupuncture has been shown in previous studies to be an effective adjunctive therapy for the treatment of PD, particularly in improving motor and nonmotor symptoms. Some studies even suggest that acupuncture may be more effective than western medicine alone in treating PD (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

A study on the effects of the Qihuang Needle therapy on patients with Parkinson's disease

Zhou²,

He³

et al. 2023

Front. Neurol.

View full text Add to dashboard Cite

ObjectiveThis study aimed to evaluate the effectiveness of the Qihuang Needle (QHN) in treating Parkinson's disease (PD).Design, setting, and participantsThe trial was an 8-week randomized clinical trial (4 weeks of treatment followed by 4 weeks of follow-up) conducted from January 2021 to July 2022 in outpatient settings at three clinical sites in Guangzhou, China. Thirty-four participants with PD were diagnosed based on the diagnostic criteria formulated by the brain bank of the British Parkinson's Disease Society in 1992.InterventionsPatients in the treatment and control groups received six sessions within 4 weeks of the QHN therapy or the sham acupuncture therapy (two times per week for the first two consecutive weeks and one time per week for the following two consecutive weeks).Main outcomes and measuresThe primary outcome measure was the change in the Parkinson's Disease Rating Scale-Part III Motor Examination (UPDRS III) between baseline and 8 weeks after treatments. Secondary outcome measures were the Non-Motor Symptoms Scale for Parkinson's Disease (NMSS) and Parkinson's Disease Daily Quality of Life-39 (PDQ-39). Real-time shear wave elastography (SWE) was assessed for each patient at baseline and during the 4-week period as the third outcome measure.ResultsA more significant reduction of UPDRS III score, PDQ-39, NMSS, and SWE was observed in the QHN group than in the sham acupuncture group.ConclusionsThe QHN therapy consistently demonstrated superiority and produced clinically meaningful benefits in reducing motor and non-motor symptoms, as well as significantly improving muscle stiffness, in patients with PD.

show abstract

Efficacy of Acupuncture for Parkinson’s Disease Anxiety: Two-Stage Protocol for a Randomized Controlled Clinical Trial

Cited by 2 publications

References 26 publications

Effectiveness of Acupuncture for Anxiety Among Patients With Parkinson Disease

Effectiveness of Acupuncture for Anxiety Among Patients With Parkinson Disease

A study on the effects of the Qihuang Needle therapy on patients with Parkinson's disease

Contact Info

Product

Resources

About