Efficacy of a soy rich diet in preventing postmenopausal osteoporosis: the Menfis randomized trial

Chiechi, Luigi Mario; Secreto, Giorgio; D’Amore, Simona; Fanelli, Margherita; Venturelli, Elisabetta; Cantatore, Francesco Paolo; Valerio, Teresa D.; Laselva, G.; Loizzi, P

doi:10.1016/s0378-5122(02)00158-5

Cited by 100 publications

(54 citation statements)

References 26 publications

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“…76,77 Diminution of bone loss, indicated by a reduction in biochemical markers of bone resorption, was found in some studies 78,80,81 but not in others. 38,44,53,55,82,83 The amounts of isoflavones were similar in studies that found favorable or no effects. The longest study in any primate species was in postmenopausal monkeys (cynomolgus macaques); after 3 years, soy isoflavones did not slow bone loss, whereas estrogen replacement increased bone mineral content and density, as expected.…”

Section: Osteoporosissupporting

confidence: 52%

Soy Protein, Isoflavones, and Cardiovascular Health

Sacks¹,

Lichtenstein²,

Horn³

et al. 2006

Circulation

581

153

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Abstract-Soy protein and isoflavones (phytoestrogens) have gained considerable attention for their potential role in improving risk factors for cardiovascular disease. This scientific advisory assesses the more recent work published on soy protein and its component isoflavones. In the majority of 22 randomized trials, isolated soy protein with isoflavones, as compared with milk or other proteins, decreased LDL cholesterol concentrations; the average effect was Ϸ3%. This reduction is very small relative to the large amount of soy protein tested in these studies, averaging 50 g, about half the usual total daily protein intake. No significant effects on HDL cholesterol, triglycerides, lipoprotein(a), or blood pressure were evident. Among 19 studies of soy isoflavones, the average effect on LDL cholesterol and other lipid risk factors was nil. Soy protein and isoflavones have not been shown to lessen vasomotor symptoms of menopause, and results are mixed with regard to soy's ability to slow postmenopausal bone loss. The efficacy and safety of soy isoflavones for preventing or treating cancer of the breast, endometrium, and prostate are not established; evidence from clinical trials is meager and cautionary with regard to a possible adverse effect. For this reason, use of isoflavone supplements in food or pills is not recommended. Thus, earlier research indicating that soy protein has clinically important favorable effects as compared with other proteins has not been confirmed. In contrast, many soy products should be beneficial to cardiovascular and overall health because of their high content of polyunsaturated fats, fiber, vitamins, and minerals and low content of saturated fat.

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Section: Osteoporosissupporting

confidence: 52%

Soy Protein, Isoflavones, and Cardiovascular Health

Sacks¹,

Lichtenstein²,

Horn³

et al. 2006

Circulation

581

153

View full text Add to dashboard Cite

show abstract

“…Our literature search identified 31 RCTs. Twenty-two studies were excluded because of lack of indices of interest (Agnusdei et al, 1997a, b;Gambacciani et al, 1997a, b;Potter et al, 1998;Alekel et al, 2000;Wangen et al, 2000;Clifton-Bligh et al, 2001;Katase et al, 2001;Anderson et al, 2002;Chiechi et al, 2002;Lucas et al, 2002;Chen et al, 2003Chen et al, , 2004Jones et al, 2003;Schult et al, 2003;Atkinson et al, 2004;Harkness et al, 2004;Olsen et al, 2004;Mori et al, 2004a, b), non-randomization (Dalais et al, 1998), lack of a control group (Agnusdei et al, 1997a, b), insufficient original data or baseline values (Gambacciani et al, 1997a, b;Khalil et al, 2002). Thus, nine studies with a total of 432 subjects were included in this meta-analysis, in which five studies had quality score of five; three studies had quality score of four and one study had quality score of three (Morabito et al, 2002;Uesugi et al, 2002;Yamori et al, 2002;Arjmandi et al, 2003Arjmandi et al, , 2005Dalais et al, 2003;Brooks et al, 2004;Mori et al, 2004a, b;Nikander et al, 2004) (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials

et al. 2007

Eur J Clin Nutr

129

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Objective: To clarify the effects of isoflavone intake on bone resorption and bone formation. Methods: We identified randomized controlled trials related to urinary deoxypyridinoline (Dpyr, a bone resorption marker) and serum bone-specific alkaline phosphatase (BAP, a bone formation marker) listed on MEDLINE (January 1966-April 2006, the Cochrane Controlled Trials Register, EMBASE (1985( -January 2006, Science Citation Index and PUBMED (updated till April 2006). Results: Nine studies with a total of 432 subjects were selected for meta-analysis. The urinary Dpyr concentration in subjects who consumed isoflavones decreased significantly by À2.08 nmol/mmol (95% confidence interval (CI): À3.82 to À0.34 nmol/ mmol) in comparison with that in subjects who did not consume isoflavones. Isoflavone intake vs placebo intake significantly increased serum BAP by 1.48 mg/l (95% CI: 0.22-2.75 mg/l). Decreases in the urinary Dpyr concentration with isoflavone intake of o90 mg/day and with treatment lasting less than 12 weeks were À2.34 nmol/mmol (95% CI: À4.46 to À0.22 nmol/mmol) and À2.03 nmol/mmol (95% CI: À3.20 to À0.85 nmol/mmol), respectively. Conclusions: Isoflavone intervention significantly inhibits bone resorption and stimulates bone formation. These favorable effects occur even if o90 mg/day of isoflavones are consumed or the intervention lasts less than 12 weeks.

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“…Chiechi et al (2002a) reported that soy rich diet, containing high levels of active phytoestrogens, can provide some protection against postmenopausal osteoporosis. They also found that diet is not as effective as hormone replacement therapy (Chiechi et al, 2002a).…”

Section: Discussionmentioning

confidence: 99%

Can Soy Change Serum Estradiol Concentration in Neonate Ovariectomized Rat?

N.¹

2012

American Medical Journal

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Problem statement: Phytoestrogens are plant derived compound found in a wide variety of foods, most notably soy. The purpose of this study was to assess the effect of soy isoflavones on circulating 17-β estradiol in neonate ovariectomized rat. Approach: Thirty, one day olds rats were used. Blood sample were collected after two months. 17-β estradiol was assayed by radioimmuno assay method. Data were analyzed by one way ANOVA and Duncan as post-hoc test. The level of significance was considered p<0.05. Results: Our data showed that ovariectomy significantly (p<0.05) reduced serum 17-β estradiol. Application of soy in doses 0.75 and 1.5 mL kg −1 day −1 following ovariectomy had not significant effect relative to ovariectomy without application of soy, but application of soy in dose 3 mL kg −1 day −1 significantly (p<0.05) increased 17-β estradiol relative to ovariectomy without application of soy. There was no significant difference between dose 3 mL kgday −1 and control and sham group. Conclusion/Recommendation: Our results indicated that soy milk isoflavone can compensate the 17-β estradiol decrease in ovariectomized rat.

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Efficacy of a soy rich diet in preventing postmenopausal osteoporosis: the Menfis randomized trial

Cited by 100 publications

References 26 publications

Soy Protein, Isoflavones, and Cardiovascular Health

Soy Protein, Isoflavones, and Cardiovascular Health

Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials

Can Soy Change Serum Estradiol Concentration in Neonate Ovariectomized Rat?

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