Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials

Abstract

Objective: To clarify the effects of isoflavone intake on bone resorption and bone formation. Methods: We identified randomized controlled trials related to urinary deoxypyridinoline (Dpyr, a bone resorption marker) and serum bone-specific alkaline phosphatase (BAP, a bone formation marker) listed on MEDLINE (January 1966-April 2006, the Cochrane Controlled Trials Register, EMBASE (1985( -January 2006, Science Citation Index and PUBMED (updated till April 2006). Results: Nine studies with a total of 432 subjects were selected for meta-analysis. The urinary Dpyr concentration in subjects who consumed isoflavones decreased significantly by À2.08 nmol/mmol (95% confidence interval (CI): À3.82 to À0.34 nmol/ mmol) in comparison with that in subjects who did not consume isoflavones. Isoflavone intake vs placebo intake significantly increased serum BAP by 1.48 mg/l (95% CI: 0.22-2.75 mg/l). Decreases in the urinary Dpyr concentration with isoflavone intake of o90 mg/day and with treatment lasting less than 12 weeks were À2.34 nmol/mmol (95% CI: À4.46 to À0.22 nmol/mmol) and À2.03 nmol/mmol (95% CI: À3.20 to À0.85 nmol/mmol), respectively. Conclusions: Isoflavone intervention significantly inhibits bone resorption and stimulates bone formation. These favorable effects occur even if o90 mg/day of isoflavones are consumed or the intervention lasts less than 12 weeks.

Prevention of bone resorption by intake of phytoestrogens in postmenopausal women: a meta-analysis

“…Although some animal studies are confirming the most significant effect of low-dose phytoestrogens on bone retention rather than high doses (Anderson et al 1998), however, Devareddy et al (2006 indicated that higher doses of phytoestrogens are necessary for reversing bone loss. Also the results of a former metaanalysis confirm our results (Ma et al 2008). Ma et al (2008) reported significant bone resorption inhibition even with less than 90-mg isoflavone a day for less than 3 months.…”

“…Also the results of a former metaanalysis confirm our results (Ma et al 2008). Ma et al (2008) reported significant bone resorption inhibition even with less than 90-mg isoflavone a day for less than 3 months. Interestingly, Uesugi et al (2002) found significant reduction of Pyd and Dpyd in less than a month, but Atkinson et al (2004) could not find any significant effect in 1 year.…”

“…Morabito et al (2002) could see the significant results as soon as 6 months. In contrast to our results, Ma et al (2008) reported significant changes in BALP after phytoestrogens consumption. Our former study on the effect of n-3 fatty acids on bone biomarkers resulted significant change in urine Pyd levels as soon as after 2 month n-3 fatty acid consumption (Salari et al 2010).…”

Oestrogen receptor genotype modulates response of P1NP, a marker of bone formation to dietary isoflavone intervention in European postmenopausal women

“…The evidence that IF may exert a protective effect against postmenopausal bone-loss from intervention studies is mixed; however, two recent meta-analysis suggest an overall significant effect of IF supplementation on increasing spinal bone mineral density (BMD) and decreasing bone turnover (1,2) . Polymorphisms in the OR gene may modulate the response of bone to IF supplementation.…”

Isoflavonoid Accumulation Pattern as Affected by Shading from Maize in Soybean (Glycine max (L.) Merr.) in Relay Strip Intercropping System

“…Epidemiological studies indicated that soy isoflavone consumption may protect against certain types of cancers, some hormone-related diseases (breast, prostate, and colon cancers etc.) and reduce bone loss, due to its estrogenic activities and other biological activities (Davies et al, 1999;Pool-Zobel et al, 2000;Akaza et al, 2002;Hikosaka et al, 2004;Hu and Knobf, 2004;Vastag, 2007;Ma et al, 2008;Taylor et al, 2009;Kang et al, 2010). Isoflavone biosynthesis is affected by several factors, and their concentration and profile mainly depend on genotype, environment, cultivation conditions and other conditions during seed maturation (Wang and Murphy, 1994;Caldwell et al, 2005;Chennupati et al, 2011;Vamerali et al, 2012).…”