Efficacy of a polyurethane dressing versus a soft silicone sheet on hypertrophic scars

Abstract

This study was funded by Beiersdorf AG. proDERM is an independent research company, and none of the authors have an interest in the sponsors commercial activities.

Decreased granulomatous reaction by polyurethane‐coated stent in the trachea

“…7 Polyurethane dressings were more efficient than silicone sheets on hypertrophic scars. 8 Thus, polyurethane demonstrates low bioactivity, suggesting that a polyurethane-coated metallic stent is a reasonable choice to reduce biohistological reaction in the trachea of children.…”

Designed drug-release systems having various breathable polyurethane film-backed hydrocolloid acrylated adhesive layers for moisture healing

“…In cases where pharmaceuticals are not being administered, the new drug-release system could be used as a wound dressing for clear moisture healing [1]. Several important findings point to the efficacy of moist wound healing [1,[26][27][28]. For example, cells proliferate and migrate faster in a moist healing environment such that the healing process is two times faster than it is in a completely dry environment.…”

“…Dehydration causes neurons to generate more pain signals in a dry healing environment of wound bed [1]. Oppositely, the exposed peripheral neurons in a moist healing environment of wound bed would generate fewer pain signals such that patients feel more comfortable during the healing process [1,[26][27][28].…”

“…The water uptake value of 600% for 240 hours is almost half the uptake value of 1200% for 160 hours. This might be due to the dissociation of sodium alginate in the designed drugrelease system having breathable polyurethane film-backed sodium alginate (NaAL) hydrocolloid acrylated adhesive layer [26][27][28]. The interpenetrating polymer network (IPN) structure of the designed drug-release system would break down.…”

Layer‐by‐layer self‐assembly of collagen and chitosan biomolecules on polyurethane films

“…Although polyurethane films have good transparency, excellent strength, flexibility, and blood compatibility, they need surface modification to increase cell adhesion and antibacterial properties. [1,2] Among the new methods for surface modification, the use of biomolecules such as heparin, chondroitin sulfate, gelatin, collagen, alginate, hyaluronic acid, and chitosan showed a significant role in improving the surface biocompatibility properties. [3] Collagen, found in the extracellular matrix, is the most abundant protein in the body.…”