Efficacy of a Pelargonium Sidoides Preparation in Patients With the Common Cold: A Randomized, Double Blind, Placebo-Controlled Clinical Trial

Lizogub, V.; Riley, David S.; Heger, Marianne

doi:10.1016/j.explore.2007.09.004

Cited by 73 publications

(63 citation statements)

References 37 publications

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“…Other Randomized Controlled Trials (RCTs) investigating the efficacy of EPs 7630 in acute bronchitis and the common cold (15)(16)(17)(18)(19)(20)(21) likewise demonstrated a reduction of time to onset of symptom alleviation as compared to placebo, thus indicating a beneficial effect of EPs 7630 in RTI and supporting the findings obtained in the presented trial.…”

Section: Discussionsupporting

confidence: 84%

“…Meanwhile, a series of placebo-controlled clinical trials have been published, showing the efficacy and tolerability of EPs 7630 in adults and children with acute bronchitis (15)(16)(17)(18)(19)(20) and adults with the common cold (21). The outcome measure employed in the trials investigating EPs 7630 in acute bronchitis, the bronchitis severity scale (BSS), comprises of five symptoms indicative of acute bronchitis, namely coughing, sputum production, rales/rhonchi at auscultation, chest pain during coughing, and dyspnea, and is a reliable tool for assessing actual symptom severities in acute bronchitis.…”

Section: Objectivesmentioning

confidence: 99%

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Clinical Efficacy and Safety of Liquid Pelargonium sidoides Preparation (EPs 7630) in Children with Acute Non-Streptococcal Tonsillopharyngitis

Бережной

Heger

Lehmacher³

et al. 2016

J Compr Ped

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Section: Discussionsupporting

confidence: 84%

Section: Objectivesmentioning

confidence: 99%

Clinical Efficacy and Safety of Liquid Pelargonium sidoides Preparation (EPs 7630) in Children with Acute Non-Streptococcal Tonsillopharyngitis

Бережной

Heger

Lehmacher³

et al. 2016

J Compr Ped

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“…Pelargonium sidoides is a traditional medicinal plant of South Africa and Lesotho that has been widely evaluated for its use in the treatment of upper respiratory tract infections (Matthys et al, 2003(Matthys et al, , 2007Chuchalin et al, 2005;Lizogub et al, 2007). The beneficial effects of PS can be attributed to its antiviral, antibacterial and immunomodulatory activity (Kayser and Kolodziej, 1997;Kayser et al, 2001;Kolodziej et al, 2003;Koch et al, 2006;Lewu et al, 2006;Mativandlela et al, 2006;Conrad et al, 2007;Nöldner and Schötz, 2007;Schnitzler et al, 2008: Michaelis et al, 2011.…”

Section: Introductionmentioning

confidence: 99%

Activity-guided isolation and identification of the major antioxidant and anticancer compounds from a commercial Pelargonium sidoides tincture

et al. 2015

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Extracts prepared from the roots of Pelargonium sidoides (DC) are commercially available for the treatment of respiratory related conditions. Recently, a commercial radix mother tincture of this plant was shown to have both antioxidant and anticancer effects especially related to the G 0 /G 1 block in the Jurkat E6.1 cell line (unpublished results). Fractions were prepared by semi-preparative HPLC, and their antioxidant and anticancer activities were determined. The more hydrophilic fractions isolated namely F6-F12 were all found to have strong reducing capacities and were able to scavenge peroxyl radicals. In the human lung cell line, NCI-H460, significant cellular antioxidant effects were observed. Anticancer activity was evaluated in the NCI-pre-screen panel (NCI-H460, MCF-7 and SF-268) and the Jurkat E6.1 cell line. Fractions F7, F9 and F12 were found to inhibit the cell growth of these four 1 cell-lines (p < 0.05), especially the Jurkat E6.1 cell line with the sulforhodamine B assay.Mass spectrometry analysis revealed that these active fractions contained several polyphenolic compounds such as gallic acid, trihydroxycoumarin, dihydroxycoumarin sulfates, proanthocyanidins and phenolic glycosides. A phenolic acid glycoside sulfate not previously shown in Pelargonium sidoides extracts was also isolated. In conclusion, the antioxidant and/or anticancer activity of the Pelargonium sidoides tincture may be attributed to the presence of these polyphenolics.

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“…direct antibacterial capabilities against a spectrum of Grampositive and Gram-negative bacteria were accompanied by significant immunostimulatory properties (Kolodziej & Kiderlen, 2007), where the results in clinical trials showed significant effectiveness as compared with placebo (Lizogub et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

T cell regulation byPhlomis lanataprotein extracts in mice

Karali

Georgescu

Pirintsos

et al. 2015

Pharmaceutical Biology

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Context: Phytopharmacology is a complex but very promising research area. The different plant parts and extraction methods may result in opposed effects. Phlomis species have been reported for both anti-inflammatory and tonic properties. Objective: The effect of Phlomis lanata Willd. (Lamiaceae) protein extracts on immune cell reactivity was studied in the experimental mouse model. Materials and methods: Protein extracts from P. lanata aerial parts were fractionated by Q-sepharose ion-exchange chromatography and applied to whole spleen cells or T-cell subsets at 5 mg/ml. Cell growth and cytokine production were evaluated after 4 and 2 d of culture using 3 H-thymidine-uptake and ELISA techniques, respectively. Results: Among the protein fractions tested, column wash proteins (W1) and the fraction eluted using 600 mM NaCl (F6) reduced by 76% and increased by 78% spleen cell proliferation, respectively. W1 suppressed proliferation of effector T-cells, but stimulated the growth of suppressor/regulatory cells by 62-148%. Although W1 stimulated IL-2 and IL-10 production from total spleen cells, it significantly increased IL-10 (50%) and reduced IL-2 (30-50%) production from T-cells, while TNF-a release was enhanced in CD25 + CD4 + by 92% and reduced by 50% in CD25 + CD8 + cells. F6 stimulated whole spleen cell growth, reduced proliferation of CD8 + and CD25 + cells by approximately 50%, while decreasing by 60-80% TNF-a production from CD25À and CD25 + CD8 + cells. Discussion and conclusion: The suppressive activity of W1 could be attributed to IL-10 and TNF-a, while the stimulatory effect of F6 could be attributed to the inhibition of T-regulatory cells. In the same plant, coexisting protein fractions induce both immunostimulatory and immunosuppressive activities.

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Efficacy of a Pelargonium Sidoides Preparation in Patients With the Common Cold: A Randomized, Double Blind, Placebo-Controlled Clinical Trial

Cited by 73 publications

References 37 publications

Clinical Efficacy and Safety of Liquid Pelargonium sidoides Preparation (EPs 7630) in Children with Acute Non-Streptococcal Tonsillopharyngitis

Clinical Efficacy and Safety of Liquid Pelargonium sidoides Preparation (EPs 7630) in Children with Acute Non-Streptococcal Tonsillopharyngitis

Activity-guided isolation and identification of the major antioxidant and anticancer compounds from a commercial Pelargonium sidoides tincture

T cell regulation byPhlomis lanataprotein extracts in mice

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