Clinical Efficacy and Safety of Liquid Pelargonium sidoides Preparation (EPs 7630) in Children with Acute Non-Streptococcal Tonsillopharyngitis

Abstract

Background: Acute tonsillopharyngitis is amongst the most common reasons for children, adolescents and young adults to consult with a physician. Despite extensive prescription, antibiotic therapy is indicated in less than one-fifth of these cases. New treatment strategies for patients with non-group-A-streptococcal acute tonsillopharyngitis are therefore required.

Faster recovery and reduced paracetamol use – a meta-analysis of EPs 7630 in children with acute respiratory tract infections

“…The analyses of the symptom scales pre-defined as primary outcome measures of the trials included into this meta-analysis confirm that EPs 7630 is efficacious in reducing the symptom burden and in accelerating recovery in children suffering from AB or ATP [55][56][57][58][59][60]. This meta-analysis adds to the existing evidence by demonstrating that EPs 7630 also reduces the use of paracetamol and enables ATP-and AB-affected children to return to school earlier, thus effectively shortening the course of the disease.…”

“…Our searches identified a total of 17 unique publications [31,34,[55][56][57][58][59][60][61][62][63][64][65][66][67][68][69]. Five were review articles from which no additional original publications meeting our selection criteria could be inferred [31,34,[61][62][63].…”

“…One publication [69] reported on a pilot study with 28 participating children, but all participants were under 6 years of age, and the authors did not report on paracetamol consumption. The remaining 6 publications [55][56][57][58][59][60] met our eligibility criteria and were included into the meta-analysis ( Fig. 1).…”

“…Three studies (A, B and C) [55,56,60] investigated the efficacy and safety of EPs 7630 in ATP according to similar protocols. They included girls and boys between 6 and 10 years of age who presented with signs and symptoms of ATP persisting for ≤48 h. A negative rapid antigen-detection test for β-haemolytic streptococci was required in order to exclude children with GAS.…”

<em>Pelargonium sidoides</em> extract EPs 7630: a review of its clinical efficacy and safety for treating acute respiratory tract infections in children

“…Two of these trials, 29 , 30 which included 143 29 and 124 30 children, respectively, followed comparable protocols. Children were randomized to a 6-day treatment with either 3×20 drops/d EPs 7630 or matched placebo, the respective distributions being 73 vs 70 29 and 60 vs 64.…”