Efficacy of a paracetamol–pseudoephedrine combination for treatment of nasal congestion and pain-related symptoms in upper respiratory tract infection

Eccles, Ronald; Jawad, M. S. M.; Jawad, S. S. M.; Ridge, D.; North, Michelle L.; Jones, Emily; Burnett, I.

doi:10.1185/030079906x154105

Cited by 26 publications

(18 citation statements)

References 14 publications

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“…While we are not aware of previous studies exploring time to onset of symptom relief with ibuprofen/pseudoephedrine combinations, these values are in line with previous, placebo‐controlled studies on pseudoephedrine monotherapy in common cold patients, being based on subjective symptom relief3, 4, 14 or on objective measurements of nasal airway flow or resistance 4, 10, 14, 15, 18. They are also in line with the pharmacokinetic properties of pseudoephedrine which reaches t max at about 60 minutes with almost maximum plasma concentrations being observed at 30 min (earliest measured time point)6, 16; t max of ibuprofen is also seen after about 60 minutes 6.…”

Section: Discussionsupporting

confidence: 82%

“…Specifically, pseudoephedrine was found to reduce subjective or objective measures of congestion3, 8, 10, 16 but has little effect on sneezing,8 on pain10 or on non‐congestion cold symptoms in general 3. In the present survey, the ibuprofen/pseudoephedrine combination product differentially affected the extent of intra‐individual improvement of specific symptoms.…”

Section: Discussionmentioning

confidence: 55%

“…Based on the pharmacodynamic profile of ibuprofen and pseudoephedrine as well as based on dedicated studies,10 neither monotherapy is likely to provide relief of all four major symptoms, lending support to the concept of using combination treatment in patients with multiple symptoms. Accordingly, such combination treatment was superior to monotherapy in controlled clinical trials 6.…”

Section: Discussionmentioning

confidence: 95%

“…To reflect real‐world conditions a patient survey was performed, which excludes a placebo group. This was not deemed necessary as the efficacy of ibuprofen,6 pseudoephedrine3, 6, 7, 8, 10, 14, 15, 16, 17, 18 or their combination6, 7 in the treatment of common cold symptoms has been established in multiple placebo‐controlled studies. Moreover, common cold sufferers had correctly identified whether they were on active treatment or placebo in previous studies,8 questioning the value of a placebo group in this indication.…”

Section: Discussionmentioning

confidence: 99%

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Factors associated with efficacy of an ibuprofen/pseudoephedrine combination drug in pharmacy customers with common cold symptoms

Klimek

Schumacher²,

Schütt

et al. 2016

Int J Clin Pract

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SummaryAimThe aim of this study was to explore factors affecting efficacy of treatment of common cold symptoms with an over‐the‐counter ibuprofen/pseudoephedrine combination product.MethodsData from an anonymous survey among 1770 pharmacy customers purchasing the combination product for treatment of own common cold symptoms underwent post‐hoc descriptive analysis. Scores of symptoms typically responsive to ibuprofen (headache, pharyngeal pain, joint pain and fever), typically responsive to pseudoephedrine (congested nose, congested sinus and runny nose), considered non‐specific (sneezing, fatigue, dry cough, cough with expectoration) and comprising all 11 symptoms were analysed. Multiple regression analysis was applied to explore factors associated with greater reduction in symptom intensity or greater probability of experiencing a symptom reduction of at least 50%.ResultsAfter intake of first dose of medication, typically ibuprofen‐sensitive, pseudoephedrine‐responsive, non‐specific and total symptoms were reduced by 60.0%, 46.3%, 45.4% and 52.8%, respectively. A symptom reduction of at least 50% was reported by 73.6%, 55.1%, 50.9% and 61.6% of participants, respectively. A high baseline score was associated with greater reductions in symptom scores but smaller probability of achieving an improvement of at least 50%. Across both multiple regression approaches, two tablets at first dosing were more effective than one and (except for ibuprofen‐sensitive symptoms) starting treatment later than day 2 of the cold was generally less effective.Discussion and ConclusionsEfficacy of an ibuprofen/pseudoephedrine combination in the treatment of common cold symptoms was dose‐dependent and greatest when treatment started within the first 2 days after onset of symptoms.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

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Factors associated with efficacy of an ibuprofen/pseudoephedrine combination drug in pharmacy customers with common cold symptoms

Klimek

Schumacher²,

Schütt

et al. 2016

Int J Clin Pract

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“…Fixed combinations of analgesics and decongestant are commonly used for symptomatic treatment of common cold and flu [4] [10] [11]. The rationale for the treatment is that nasal congestion and pain commonly occur simultaneously and that a combination medicine provides a simplification of therapy compared to use of an analgesic and a decongestant as mono-therapies [4].…”

Section: Introductionmentioning

confidence: 99%

Aspirin plus Pseudoephedrine (Aspirin Complex) for the Treatment of Symptoms of Upper Respiratory Tract Infection

Voelker¹,

Eccles²,

Gessner³

2017

OJRD

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Upper respiratory tract infections or common colds are a multi-symptom disease which is usually symptomatically treated with fixed dose multi-active ingredient medicinal products which are commonly used as non-prescription and over the counter. However, the active ingredients combined require a particular and clinically sound justification. Analgesics and decongestant can be combined to treat simultaneously the prominent symptoms cold-related pain (e.g. headache, muscle aches and pains), fever, inflammationand nasal/sinus congestion. This overview provides a summary of the evidence supporting the combination of acetylsalicylic acid (aspirin) and pseudoephedrine available in the common cold product Aspirin  Complex.

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Oral antihistamine-decongestant-analgesic combinations for the common cold

Sutter

Driel

Kumar

et al. 2012

Cochrane Database of Systematic Reviews

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Background Although combination formulas containing antihistamines, decongestants and/or analgesics are sold over-the-counter (OTC) in large quantities for the common cold, the evidence of effectiveness is limited. Objectives To assess the effectiveness of antihistamine-decongestant-analgesic combinations in reducing the duration and alleviating the symptoms of the common cold in adults and children.

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Efficacy of a paracetamol–pseudoephedrine combination for treatment of nasal congestion and pain-related symptoms in upper respiratory tract infection

Abstract: The combination treatment provided a greater decongestant effect than either paracetamol or placebo and better pain relief than either pseudoephedrine or placebo. The additive effect of the combination was apparent for both single and multiple doses.

Cited by 26 publications

References 14 publications

Factors associated with efficacy of an ibuprofen/pseudoephedrine combination drug in pharmacy customers with common cold symptoms

Factors associated with efficacy of an ibuprofen/pseudoephedrine combination drug in pharmacy customers with common cold symptoms

Aspirin plus Pseudoephedrine (Aspirin Complex) for the Treatment of Symptoms of Upper Respiratory Tract Infection

Oral antihistamine-decongestant-analgesic combinations for the common cold

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