Oral antihistamine-decongestant-analgesic combinations for the common cold

Sutter, An I. M. De; Driel, Mieke van; Kumar, Anna A; Lesslar, Olivia; Skrt, Alja

doi:10.1002/14651858.cd004976.pub3

Cited by 66 publications

(30 citation statements)

References 36 publications

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“…Owing to the high morbidity, mortality and healthcare costs, effective prevention and treatment of RTIs are a high priority worldwide. 7,8 Treatment is focused on symptom relief, such as antihistamines and decongestants for nasal congestion 9 and antitussives for cough. 10,11 Although antibiotics are only indicated in a minority of patients, they are often unnecessarily prescribed for viral infections against which they have no effect.…”

Section: Burden and Management Of Rtismentioning

confidence: 99%

Immunity‐targeted approaches to the management of chronic and recurrent upper respiratory tract disorders in children

Feleszko

Marengo

Vieira

et al. 2019

Clinical Otolaryngology

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BackgroundUpper respiratory tract infections (URTIs), including rhinitis, nasopharyngitis, tonsillitis and otitis media (OM), comprise of 88% of total respiratory infections, especially in children. Therefore effective prevention and treatment of RTIs remain a high priority worldwide. Preclinical and clinical data highlight the rationale for the use and effectiveness of immunity‐targeted approaches, including targeted immunisations and non‐specific immunomodulation in the prevention and management of recurrent upper RTIs.Objective of reviewThe idea of this review was to summarise the current evidence and address key questions concerning the use of conservative and immunity‐targeted approaches to recurrent and chronic URTIs, with a focus on the paediatric population.Search strategy/Evaluation methodLiterature searches were conducted in March 2017 and updated in September 2017 using: Academic Search Complete; CENTRAL; Health Source: Nursing/Academic Edition; MEDLINE; clinicaltrials.gov; and Cochrane databases. In total, 84 articles were retrieved and reviewed. Two independent researchers focused on primary and secondary endpoints in systematic reviews, meta‐analyses and randomised, controlled trials, using immunity‐directed strategies as the control group or within a subpopulation of larger studies. Existing guidelines and interventional/observational studies on novel applications were also included.ResultsChildren are particularly susceptible to RTIs due to the relative immaturity of their immune systems, as well as other potential predisposing factors such as day care attendance and/or toxic environmental factors (eg increased pathogenic microbial exposure and air pollutants). Recurrent URTIs can affect otherwise healthy children, leading to clinical sequelae and complications, including the development of chronic conditions or the need for surgery. Available pre‐clinical and clinical data highlight the rationale for the use and effectiveness of immunity‐targeted approaches, including targeted immunisations (flu and pneumococcal vaccines) and non‐specific immunomodulation (bacterial lysates), in the prevention and management of recurrent croup, tonsillitis, otitis media, recurrent acute rhinosinusitis and chronic rhinosinusitis.ConclusionsIn this review, we summarise the current evidence and provide data demonstrating that some immunity‐targeted strategies, including vaccination and immunomodulation, have proved effective in the treatment and prevention of recurrent and chronic URTIs in children.

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Section: Burden and Management Of Rtismentioning

confidence: 99%

Immunity‐targeted approaches to the management of chronic and recurrent upper respiratory tract disorders in children

Feleszko

Marengo

Vieira

et al. 2019

Clinical Otolaryngology

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“…A more recent Cochrane analysis from 2012 [46] concluded that antihistamines combined with decongestants and analgesics could reduce the duration of the disease and relieve the symptoms. The authors, therefore, recommended a combination of antihistamines with decongestants and analgesics for adults after considering the possible side effects.…”

Section: Types and Therapies Of Nasal Obstructionmentioning

confidence: 99%

“…Only in acute viral rhinosinusitis was a positive effect on nasal obstruction observed after 3–10 hours [35]. In a Cochrane review [46], only the combination of decongestants with antihistamines and analgesics were shown to reduce the disease duration and relieve the symptoms, such that these combinations were recommended as a treatment for adults when the side effects are carefully taken into consideration.…”

Section: Types and Therapies Of Rhinosinusitismentioning

confidence: 99%

Evidence and evidence gaps in therapies of nasal obstruction and rhinosinusitis

Rotter¹

2016

GMS Current Topics in Otorhinolaryngology - Head and Neck Surgery; 15:Doc06

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“…First-generation antihistamines improve runny nose and sneezing, but their use in children should be avoided [73]. In combination with decongestant they are more effective but have adverse effects such as drowsiness, dry mouth, insomnia and dizziness [74]. Second-generation antihistamines do not seem to have an effect [74].…”

Section: Treatmentmentioning

confidence: 99%

“…In combination with decongestant they are more effective but have adverse effects such as drowsiness, dry mouth, insomnia and dizziness [74]. Second-generation antihistamines do not seem to have an effect [74]. Nasal and oral decongestants provide short term relief but their use is limited by adverse effects (rhinitis medicamentosa and rebound congestion) [75].…”

Section: Treatmentmentioning

confidence: 99%

The Common Cold: Potential for Future Prevention or Cure

Passioti

Maggina

Megremis

et al. 2014

Curr Allergy Asthma Rep

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The common cold is the most frequent, although generally mild, human disease. Human Rhinoviruses are the prevalent causative agents, but other viruses are also implicated. Being so common, viral colds, have significant implications on public health and quality of life, but may also be life-threatening for vulnerable groups of patients. Specific diagnosis and treatment of the common cold still remain unmet needs. Molecular diagnostic techniques allow specific detection of known pathogens as well as the identification of newly emerging viruses. Although a number of medications or natural treatments have been shown to have some effect, either on the number or on the severity of common colds, no single agent is considerably effective. Virus-specific management remains in most cases a challenging potential as many factors have to be taken into account, including the diversity of the viral genomes, the heterogeneity of affected individuals, as well as the complexity of this long standing host-virus relationship.

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Oral antihistamine-decongestant-analgesic combinations for the common cold

Cited by 66 publications

References 36 publications

Immunity‐targeted approaches to the management of chronic and recurrent upper respiratory tract disorders in children

Immunity‐targeted approaches to the management of chronic and recurrent upper respiratory tract disorders in children

Evidence and evidence gaps in therapies of nasal obstruction and rhinosinusitis

The Common Cold: Potential for Future Prevention or Cure

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