Efficacy of a novel topical combination of fipronil, amitraz and (S)-methoprene for treatment and control of induced infestations with four North American tick species (Dermacentor variabilis, Ixodes scapularis, Amblyomma americanum and Amblyomma maculatum) on dogs

The speed of kill of fluralaner (Bravecto¿) against Ixodes ricinus ticks on dogs

“…More importantly, in several studies conducted in dogs the use of commercial acaricidal products protected from an A. phagocytophilum or E. canis infection [8,[23][24][25][26][27]. These products are described as having a slower speed of kill (i.e., time needed after treatment/ re-infestation to kill >90% of attached ticks) compared with fluralaner [23,[28][29][30][31]. Thus, fluralaner is likely to have at least the same ability to prevent A. phagocytophilum or E. canis infection in dogs.…”

Data collection for risk assessments on animal health (Acronym: DACRAH) : Final Report

“…A combination of fipronil, amitraz and (S)-methoprene had an efficacy of 1 (Baker et al, 2011) A single topical application of a combination of fipronil, amitraz and (S)-methoprene had a mean efficacy of 0.81 (28 days posttreatment) against induced infestations with four North American ixodid tick species: D. variabilis, I. scapularis, A. americanum and A. maculatum.…”

“…A combination of fipronil 6.1% and permethrin 54.5% had an efficacy of 0.95 37 days posttreatment (Kunkle et al, 2012a) The efficacy of a combination of imidacloprid and permethrin decreased overtime from 0.98 8 days post-treatment to 0.59 43 days posttreatment (Otranto et al, 2005) External usecollar/ear tag A combination of imidacloprid 10% + permethrin 50% had an efficacy of 0.99 56 days post-treatment Amitraz EC 251-375-4 (Baker et al, 2011) Substance is very toxic to aquatic life, is very toxic to aquatic life with long lasting effects, is harmful if swallowed, may cause damage to organs through prolonged or repeated exposure and may cause an allergic skin reaction.…”

“…(S)-methoprene EC 613-834-0 (Baker et al, 2011) Substance is very toxic to aquatic life, causes skin irritation and may cause respiratory irritation.…”

“…A combination of fipronil, amitraz and (S)-methoprene had an efficacy of 1 (Baker et al, 2011) A single topical application of a combination of fipronil, amitraz and (S)-methoprene had a mean efficacy of 0.81 (28 days posttreatment) against induced infestations with DACRAH Disclaimer: The present document has been produced and adopted by the bodies identified above as author(s). This task has been carried out exclusively by the author(s) in the context of a contract between the European Food Safety Authority and the author(s), awarded following a tender procedure.…”