Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel in cats againstToxocara catiandDipylidium caninum

Abstract

NexGard® Combo, a novel topical antiparasitic product for cats, combines the insecticide/acaricide esafoxolaner with the nematocide eprinomectin and cestodicide praziquantel. The efficacy of this combination product was evaluated against two common endoparasites of global occurrence in cats, the nematode Toxocara cati and the cestode Dipylidium caninum, in five controlled studies using naturally or experimentally infected cats with parasites of North American, South African or European origin. Cats evaluated in these studies harbored patent infection of the target parasite confirmed through a pre-treatment fecal examination. In each study, cats were allocated randomly to two groups of equal size (8 or 10 cats per group per study), one group treated with a placebo (mineral oil) and the other with NexGard® Combo. Both treatments were administered once as a spot-on at 0.12 mL per kg body weight to deliver the minimum label dosage (1.44 mg/kg esafoxolaner, 0.48 mg/kg eprinomectin, and 10.0 mg/kg praziquantel) to the NexGard® Combo-treated cats. To determine efficacy, geometric mean parasite counts seven to 12 days after treatment of placebo-treated (control) cats and NexGard® Combo-treated cats were compared. The efficacy of NexGard® Combo was 98.8% and 100% against adult T. cati in two studies; and 98.0%, 98.3% and 93.2% against D. caninum in three studies. No adverse events related to treatment were observed throughout the studies. These studies demonstrate high efficacy against these major feline endoparasites and excellent acceptability of the novel topical antiparasitic combination of esafoxolaner, eprinomectin and praziquantel.

Efficacy of a combination of esafoxolaner, eprinomectin and praziquantel (NexGard® Combo) against Thelazia callipaeda in naturally infected cats

“…The observed reduction in clinical signs and clearance of the infection, coupled with the absence of adverse effects and the easy-to-apply spot-on formulation, underscores its potential suitability as a treatment option. The rapid and sustained efficacy demonstrated in this study further supports the potential of the product as a valuable tool in the management and control of parasitic infection in feline populations [3,9,27].…”

Efficacy of a topical formulation containing eprinomectin, esafoxolaner and praziquantel (NexGard® Combo) in the treatment of natural respiratory capillariosis of cats

“…In conclusion, this multi-center clinical field trial demonstrated that NexGard ® Combo is a safe and highly efficacious treatment for E. aerophilus infection in cats under field conditions. The findings of this study contribute to the growing body of evidence supporting the use of NexGard ® Combo as a reliable solution for managing parasitic infections in feline populations [ 19 – 21 ].…”

Deworming Schemes’ Efficacy for Adult Dogs with Mixed Gastro-Intestinal Helminthoses

“…Both of these substances are considered as low-toxic. However, more recent studies have shown that a single dose of praziquantel-containing drugs is sufficient to kill mature cestodes in dogs [24,28] and there is no urgent need to re-feed this substance. But fighting some parasitic nematodes (T. vulpis, and in some cases T. canis), a single treatment with benzimidazoles may not be enough and should be duplicated with a daily interval [12,57].…”

“…Thus, benzimidazole compounds [27,52] or macrocyclic lactones [16,20,40] are usually used to release nematodes. Praziquantel is the most widely used substance to control trematodes and cestodes in dogs [24,28]. Niclosamide is much less commonly used today [8].…”