Efficacy of a novel topical combination of fipronil, amitraz and (S)-methoprene for treatment and control of induced infestations of brown dog ticks (Rhipicephalus sanguineus) on dogs

Hunter, James S.; Baggott, Derek; Everett, William R.; Fourie, Josephus J.; Cramer, Luiz G.; Yoon, Stephen; Collidor, Nadia; Mallouk, Yasmina; Lee, Lorne; Blair, Jeffrey; Prullage, Joseph B.

doi:10.1016/j.vetpar.2011.03.042

Cited by 19 publications

(12 citation statements)

References 11 publications

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“…In this study, reinfestations were also controlled for up to five weeks in the two studies, with efficacies greater than 95.7% at 48 h counts. This level of efficacy is similar to what has been published for topical formulations (Beugnet and Franc, 2012;Hunter et al, 2011;Kunkle et al, 2012). Afoxolaner is absorbed rapidly by the intestinal mucosa, and its plasma concentration peaks within 2-4 h after administration (Letendre et al, 2014), which ultimately results in a rapid uptake by the ticks.…”

Section: Discussionsupporting

confidence: 88%

“…The assessment of curative efficacy by counting existing ticks 48 h after treatment is a standard requirement (Marchiondo et al, 2013). This curative effect is demonstrated for the first time for an oral product whereas it is well known for many registered topical spot on formulations (Hunter et al, 2011;Kunkle et al, 2012). With regard to the curative efficacy, ticks are already attached and have started their blood meal when they are killed by acaricidal products.…”

Section: Discussionmentioning

confidence: 92%

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Assessment of the efficacy of orally administered afoxolaner against Rhipicephalus sanguineus sensu lato

Kunkle¹,

Daly²,

Dumont³

et al. 2014

Veterinary Parasitology

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Two studies were conducted to confirm that a single oral dose of the novel insecticide/acaricide afoxolaner is efficacious against existing infestations of Rhipicephalus sanguineus sensu lato in dogs and can control re-infestation for up to 35 days. Each study utilized 16 purpose bred adult dogs using a controlled randomized block design. One or two days prior to treatment, all dogs were infested with 50 unfed adult ticks. On Day 0 one group was treated with an oral chewable formulation of afoxolaner at a dose as close as possible to the minimum dose of 2.5mg/kg. Weekly re-infestations with 50 adult unfed ticks were repeated for five weeks. Forty-eight hours after treatment and after each re-infestation, the number of remaining live ticks on each dog was counted. Treatment with afoxolaner resulted in efficacies of 98.8-100% within 48 h on existing tick infestations, while the efficacy against new tick infestations was >95.7% over five weeks.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 92%

Assessment of the efficacy of orally administered afoxolaner against Rhipicephalus sanguineus sensu lato

Kunkle¹,

Daly²,

Dumont³

et al. 2014

Veterinary Parasitology

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“…The infestation and evaluation time-points in Study 1 were chosen in accordance with the products’ label claims and the Guidelines for the testing and evaluation of the efficacy of antiparasitic substances for the treatment and prevention of tick and flea infestation in dogs and cats; EMEA/CVMP/005/2000- Rev.2 and current regulatory practice regarding efficacy evaluation, namely flea counts after 24 h and tick counts after 48 h. Because the efficacies against ticks of the remedies under evaluation in Study 2 were expected to be similar at the 48 h assessment time-points, the choice of the tick counting time-point was based on data already published on the efficacy of the (s)-methoprene/amitraz/fipronil spot-on [16], namely “rapid killing” (18 h post-infestation) or “repellence” (6 h post-infestation).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of slow-release collar formulations of imidacloprid/flumethrin and deltamethrin and of spot-on formulations of fipronil/(s) - methoprene, dinotefuran/pyriproxyfen/permethrin and (s) –methoprene/amitraz/fipronil against Rhipicephalus sanguineus and Ctenocephalides felis felis on dogs

2012

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BackgroundTwo studies evaluating the efficacy of an imidacloprid/flumethrin collar (Seresto®, Bayer Animal Health, IVP), a deltamethrin collar (Scalibor®, MSD, CP1), a fipronil/(s)-methoprene spot-on (Frontline Combo®, Merial, CP2), a dinotefuran/pyriproxyfen/permethrin spot-on (Vectra 3D®, Ceva, CP3) and an amitraz/fipronil/(s)-methoprene spot-on (Certifect®, Merial, CP4/CP5) against repeated infestations with Rhipicephalus sanguineus and Ctenocephalides felis felis on dogs were conducted over periods of 226 days and 71 days respectively.MethodsThe first study comprised 4 groups of treated dogs and one untreated control group, and the second 3 groups of treated dogs and one control group. Each group consisted of 8 dogs. All dogs were infested with ticks and fleas at regular intervals. Ticks were counted 6 h, 18 h or 48 h after infestations and fleas 24 h after infestations. Efficacies of the treatments were calculated by comparison with the untreated control groups using standard descriptive statistics.ResultsThe protective 48 h tick efficacy was 97.8% to 100% for the IVP (226 days), 69.3% to 97.4% for CP1 (170 days), 99.6% to 43.4% for CP2 (35 days) and 98% to 61.4% for CP3 (35 days).The protective 18 h tick efficacy was 98% to 99.6% for the IVP (71 days), 100% to 86.5% for CP4 (29 days), 100% to 72.8% for CP4 after re-treatment (35 days) and 98.8% to 54.3% for CP5 (35 days).The protective 6 h tick efficacy was 85.6% at Day 7 and 90.1% to 97.1% from Day 14 onwards for the IVP (70 days), 92.3% to 70.7% for CP4 (35 days), 97.5% to 65.2% for CP4 after re-treatment (35 days) and 95.1% to 51.8% for CP5 (35 days).The protective 24 h flea efficacy was 99.5/90.9% to 100% for the IVP (71/226 days), 66.7% to 83% for CP1 (170 days), 100% to 88.5% for CP2 (35 days), 100% to 73.3% for CP3 (35 days), 100% to 98.7% for CP4 (35 days), 100% to 87.5% for CP4 after re-treatment (35 days) and 100% to 79.5% for CP5 (35 days).ConclusionsThese data suggest that the long-term efficacy provided by a medicated collar that is effective, is a means to overcome the fluctuating efficacy of spot-on treatments resulting from a lack of pet owner re-treatment compliance, and consequently protect animals successfully against ectoparasites and probably vector-borne diseases.

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“…More importantly, in several studies conducted in dogs the use of commercial acaricidal products protected from an A. phagocytophilum or E. canis infection [8,[23][24][25][26][27]. These products are described as having a slower speed of kill (i.e., time needed after treatment/ re-infestation to kill >90% of attached ticks) compared with fluralaner [23,[28][29][30][31]. Thus, fluralaner is likely to have at least the same ability to prevent A. phagocytophilum or E. canis infection in dogs.…”

Section: Discussionmentioning

confidence: 99%

The speed of kill of fluralaner (Bravecto¿) against Ixodes ricinus ticks on dogs

Wengenmayer¹,

Williams²,

Zschiesche³

et al. 2014

Parasites & Vectors

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Background: Pathogens that are transmitted by ticks to dogs, such as Anaplasma phagocytophilum, Babesia spp., Borrelia burgdorferi sensu latu, and Ehrlichia canis, are an increasing problem in the world. One method to prevent pathogen transmission to dogs is to kill the ticks before transmission occurs. Fluralaner (Bravecto™) is a novel isoxazoline insecticide and acaricide that provides long persistent antiparasitic activity following systemic administration. This study investigated the speed of kill of fluralaner against Ixodes ricinus ticks on dogs.

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Efficacy of a novel topical combination of fipronil, amitraz and (S)-methoprene for treatment and control of induced infestations of brown dog ticks (Rhipicephalus sanguineus) on dogs

Cited by 19 publications

References 11 publications

Assessment of the efficacy of orally administered afoxolaner against Rhipicephalus sanguineus sensu lato

Assessment of the efficacy of orally administered afoxolaner against Rhipicephalus sanguineus sensu lato

Efficacy of slow-release collar formulations of imidacloprid/flumethrin and deltamethrin and of spot-on formulations of fipronil/(s) - methoprene, dinotefuran/pyriproxyfen/permethrin and (s) –methoprene/amitraz/fipronil against Rhipicephalus sanguineus and Ctenocephalides felis felis on dogs

The speed of kill of fluralaner (Bravecto¿) against Ixodes ricinus ticks on dogs

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