Efficacy of a new long-acting formulation of ivermectin and other injectable avermectins against induced Psoroptes ovis infestations in cattle

Rehbein, Steffen; Visser, Martin; Winter, Renate; Maciel, Ana E.

doi:10.1007/s00436-002-0713-5

Cited by 17 publications

(13 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More recently, long-acting injection formulations were developed and authorized for use in several countries (Cady et al 2013). The 3.15 %w/v ivermectin longacting injectable (IVM LAI; IVOMEC® GOLD, Merial) demonstrated effective parasite control associated with improved weight gains under field conditions in South America with challenge of gastrointestinal nematode infections, tropical grubs, and Rhipicephalus (Boophilus) microplus ticks (Carvalho et al 1998(Carvalho et al , 1999a(Carvalho et al , b, 2000Alva et al 1999;Cruz et al 1999;Serra-Freire et al 1999;Bridi et al 2000;Bordin et al 2001;Malacco et al 2001), and in laboratory studies with induced nematode infections (Gogolewski et al 2006) and psoroptic mange (Bridi et al 2001;Rehbein et al 2002).…”

Section: Introductionmentioning

confidence: 94%

Activity of ivermectin long-acting injectable (IVOMEC® GOLD) in first-season grazing cattle exposed to natural challenge conditions in Germany

Rehbein¹,

Knaus²,

Visser³

et al. 2014

Parasitol Res

View full text Add to dashboard Cite

The persistent activity of ivermectin long-acting injection (IVM LAI; IVOMEC® GOLD, Merial; 3.15% ivermectin w/v) against nematode infections of cattle was evaluated under natural challenge conditions. Seventy nematode-free Brown Swiss calves were blocked by pre-treatment bodyweight and allocated randomly to seven groups of 10 animals each: saline (control) at 1 mL/50 kg bodyweight once on day 0 or IVM LAI at 1 mL/50 kg bodyweight (630 mcg IVM/kg) on either days 0, 7, 14, 21, 28, or 35. After housing until day 35, calves were grazed as one herd on a naturally contaminated pasture for 42 days. Calves were then weighed and housed for 4 weeks before being necropsied for parasite counting. Treatment with IVM LAI prevented the establishment (>90%, p < 0.05) of Dictyocaulus viviparus (100%), Bunostomum phlebotomum (100 %), Haemonchus contortus (98.6%), Ostertagia ostertagi/lyrata (94.9%), and Oesophagostomum radiatum (93.3%) for at least 77 days; Ostertagia leptospicularis (99.1%) for 63 days; Cooperia punctata (97.7%), Trichostrongylus axei (96.5%), and Ostertagia spp. inhibited larvae 4 (93.3%) for 56 days; Cooperia oncophora/surnabada (96.9%), Trichuris discolor (93.6%), and Cooperia spp. inhibited larvae 4 (98.8%); and Nematodirus spp. inhibited larvae 4 (97.1%) for 42 days. Calves of groups treated with IVM LAI had significantly (p < 0.001) higher days 0 to 77 weight gains than the saline-treated controls (28.40-39.25 vs 2.60 kg); the weight gains of the IVM LAI-treated groups, however, were not different from one another (p > 0.3). This study demonstrated a very high efficacy of IVOMEC® GOLD in preventing the establishment of a wide range of bovine nematodes for extended periods of time which was associated with a significant benefit to productivity in terms of weight gain.

show abstract

Section: Introductionmentioning

confidence: 94%

Activity of ivermectin long-acting injectable (IVOMEC® GOLD) in first-season grazing cattle exposed to natural challenge conditions in Germany

Rehbein¹,

Knaus²,

Visser³

et al. 2014

Parasitol Res

View full text Add to dashboard Cite

show abstract

“…The effectiveness of parasitic control in livestock is directly related to the duration of the antiparasitic effect of the drug on the animal (Bridi, Carvalho, Cramer, & Barrick, 2001; Rehbein, Visser, Winter, & Maciel, 2002). To extend the antiparasitic effect of a single treatment, long‐acting IVM drugs were developed by pharmaceutical industries.…”

Section: Discussionmentioning

confidence: 99%

The effect of breed, sex, and drug concentration on the pharmacokinetic profile of ivermectin in cattle

Gotardo

Fonseca

Barreto

et al. 2020

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

Ivermectin (IVM) is one of the most widely used antiparasitic drugs worldwide and has become the drug of choice for anthelmintic and tick treatment in beef cattle production. It is known that pharmacokinetic parameters are fundamental to the rational use of a drug and food safety and these parameters are influenced by different factors. The aim of this study was to evaluate the pharmacokinetic profile of IVM in Bos indicus, Bos taurus, and crossbreed cattle (B. indicus × B. taurus) kept under same field conditions and the possible impacts of sex and IVM formulation (1% and 3.15%). It was observed that IVM concentration was significantly affected by breed. The plasma concentrations of IVM, AUC, Cmax, and t1/2β were significantly higher in B. indicus compared to B. taurus. Crossbreed animals showed an intermediate profile between European and Indian cattle. No alteration in pharmacokinetics parameters was detected when comparing different gender. Concerning the pharmacokinetic data of IVM formulation, it was verified that Tmax, AUC, and t1/2β were higher in 3.15% IVM animals than those from 1% IVM formulation. The results clearly indicated that the IVM plasma concentrations in B. indicus were higher than that in B. taurus.

show abstract

“…bovis (syn. Sarcoptes bovis) [11][12][13] , Chorioptes bovis or Psoroptes ovis 12 . Although mites may infest cattle of all classes and ages, chorioptic mange is frequently prevalent in dairy cows whereas sarcoptic mange is often associated with growing cattle.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Udder Dermatitis Due to Sarcoptic Mange on Milk Yield in Dairy Cows

Ural¹,

Ural²,

Koşkan³

2013

Kafkas Univ Vet Fak Derg

View full text Add to dashboard Cite

In the present study the aim was to elucidate the relationship between udder dermatitis due to naturally occuring sarcoptic mange infestation and milk yield in dairy cattle. Field observation was carried out in a private dairy farm in Bozdogan, Aydin comprising 18 out of 80 cattle were diagnosed with udder dermatitis in association with sarcoptic mange on the basis of clinical and parasitological examinations. For assessment of milk yield production, the data set included 5490 test day yields. The actual milk yield evaluated in second lactation changed between 2594-7742 kg (with a mean milk yield: 5394±327.5 kg). The lactation periods of cows were detected between 181-306 day (the mean lactation period: 275±9.5 days). The first occurence of each lesions were included in the analysis and 6 cows had udder dermatitis in first 5 month and other cows at later lactation period. The mean daily milk loss was calculated 8.17 kg and daily milk yields loss for a cow was 0.44 kg. This pruritic disease invoving udder led severe infection and dramatic drop of milk yield among dairy cattle enrolled in the present study. Results of the present study reported herein suggested that udder dermatitis in relation to scabies could be identified in cows in all stages of the lactating period, especially the prevalence was higher in later lactation period. The milk losses consequent to udder dermatitis may cause significant economic problems.

show abstract

Efficacy of a new long-acting formulation of ivermectin and other injectable avermectins against induced Psoroptes ovis infestations in cattle

Cited by 17 publications

References 12 publications

Activity of ivermectin long-acting injectable (IVOMEC® GOLD) in first-season grazing cattle exposed to natural challenge conditions in Germany

Activity of ivermectin long-acting injectable (IVOMEC® GOLD) in first-season grazing cattle exposed to natural challenge conditions in Germany

The effect of breed, sex, and drug concentration on the pharmacokinetic profile of ivermectin in cattle

The Effects of Udder Dermatitis Due to Sarcoptic Mange on Milk Yield in Dairy Cows

Contact Info

Product

Resources

About