Efficacy of a long-acting formulation of ivermectin against Psoroptes ovis (Hering, 1838) on cattle

Bridi, A.A.; Carvalho, Luis; Cramer, Luiz G.; Barrick, R A

doi:10.1016/s0304-4017(01)00434-4

Cited by 18 publications

(16 citation statements)

References 19 publications

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“…More recently, long-acting injection formulations were developed and authorized for use in several countries (Cady et al 2013). The 3.15 %w/v ivermectin longacting injectable (IVM LAI; IVOMEC® GOLD, Merial) demonstrated effective parasite control associated with improved weight gains under field conditions in South America with challenge of gastrointestinal nematode infections, tropical grubs, and Rhipicephalus (Boophilus) microplus ticks (Carvalho et al 1998(Carvalho et al , 1999a(Carvalho et al , b, 2000Alva et al 1999;Cruz et al 1999;Serra-Freire et al 1999;Bridi et al 2000;Bordin et al 2001;Malacco et al 2001), and in laboratory studies with induced nematode infections (Gogolewski et al 2006) and psoroptic mange (Bridi et al 2001;Rehbein et al 2002).…”

Section: Introductionmentioning

confidence: 94%

Activity of ivermectin long-acting injectable (IVOMEC® GOLD) in first-season grazing cattle exposed to natural challenge conditions in Germany

Rehbein¹,

Knaus²,

Visser³

et al. 2014

Parasitol Res

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The persistent activity of ivermectin long-acting injection (IVM LAI; IVOMEC® GOLD, Merial; 3.15% ivermectin w/v) against nematode infections of cattle was evaluated under natural challenge conditions. Seventy nematode-free Brown Swiss calves were blocked by pre-treatment bodyweight and allocated randomly to seven groups of 10 animals each: saline (control) at 1 mL/50 kg bodyweight once on day 0 or IVM LAI at 1 mL/50 kg bodyweight (630 mcg IVM/kg) on either days 0, 7, 14, 21, 28, or 35. After housing until day 35, calves were grazed as one herd on a naturally contaminated pasture for 42 days. Calves were then weighed and housed for 4 weeks before being necropsied for parasite counting. Treatment with IVM LAI prevented the establishment (>90%, p < 0.05) of Dictyocaulus viviparus (100%), Bunostomum phlebotomum (100 %), Haemonchus contortus (98.6%), Ostertagia ostertagi/lyrata (94.9%), and Oesophagostomum radiatum (93.3%) for at least 77 days; Ostertagia leptospicularis (99.1%) for 63 days; Cooperia punctata (97.7%), Trichostrongylus axei (96.5%), and Ostertagia spp. inhibited larvae 4 (93.3%) for 56 days; Cooperia oncophora/surnabada (96.9%), Trichuris discolor (93.6%), and Cooperia spp. inhibited larvae 4 (98.8%); and Nematodirus spp. inhibited larvae 4 (97.1%) for 42 days. Calves of groups treated with IVM LAI had significantly (p < 0.001) higher days 0 to 77 weight gains than the saline-treated controls (28.40-39.25 vs 2.60 kg); the weight gains of the IVM LAI-treated groups, however, were not different from one another (p > 0.3). This study demonstrated a very high efficacy of IVOMEC® GOLD in preventing the establishment of a wide range of bovine nematodes for extended periods of time which was associated with a significant benefit to productivity in terms of weight gain.

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Section: Introductionmentioning

confidence: 94%

Activity of ivermectin long-acting injectable (IVOMEC® GOLD) in first-season grazing cattle exposed to natural challenge conditions in Germany

Rehbein¹,

Knaus²,

Visser³

et al. 2014

Parasitol Res

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“…For doramectin, this finding is in agreement with Clymer et al (1997) who found a protective period of doramectin treatment of 3 weeks with artificial P. ovis challenge. In a recently published study, an 8 week protection period against P. ovis infestation in cattle treated with ivermectin LAI was demonstrated using artificial challenge (Bridi et al 2001).…”

Section: Discussionmentioning

confidence: 98%

“…Recently, a long-acting injectable formulation of ivermectin for cattle was developed which has a high intrinsic endectocide activity and provides an extended period of protection against infections with gastrointestinal and pulmonary nematodes, ticks (Boophilus microplus), P. ovis mites, and tropical grubs (Dermatobia hominis) (Carvalho et al 1998(Carvalho et al , 1999aAlva et al 1999;Cruz et al 1999;Serra-Freire et al 1999;Bridi et al 2001;Merial, unpublished data). The use of the long-acting formulation in cattle under conditions of continuous grazing and constant exposure to naturally acquired field infections with gastrointestinal parasites and ticks in South America resulted in significantly improved weight gains as well as lower death rates and salvage treatments when compared to untreated cattle and to cattle treated with other endectocides Carvalho et al 2000;Bordin et al 2001;Malacco et al 2001).…”

Section: Introductionmentioning

confidence: 96%

Efficacy of a new long-acting formulation of ivermectin and other injectable avermectins against induced Psoroptes ovis infestations in cattle

Rehbein¹,

Visser²,

Winter³

et al. 2002

Parasitology Research

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Two studies describe the therapeutic and protective efficacy of commercially available, injectable avermectins against Psoroptes ovis infestations. In each study, six untreated calves were compared to groups of six calves each treated with ivermectin long-acting injectable (LAI) 3.15% w/v solution, generic long-acting (LA) ivermectin 1% w/v solution or 1% w/v doramectin solution. Treatments were carried out according to the manufacturer's instructions at 1 ml/50 kg body weight. Live mites in skin scrapings were counted prior to treatment and at weekly intervals for 8 weeks thereafter in the therapeutic study, or at 15, 21 and 28 days after P. ovis challenge which occurred 28 days post-treatment in the study to compare protective efficacy. P. ovis infested calves treated with ivermectin LAI had significantly ( P<0.05) fewer mites than did the untreated controls from 1 week after treatment. They also had significantly fewer mites at 7 and 8 weeks after treatment than did the calves treated with generic LA ivermectin and at 8 weeks after treatment than the calves treated with doramectin. No mites were counted on the animals treated with ivermectin LAI from 4 weeks after treatment through to the end of the study; however, five of the six calves from each of the groups treated with generic LA ivermectin or doramectin were infested with P. ovis at 8 weeks after treatment. No P. ovis mites were recorded on the calves treated prophylactically with ivermectin LAI. In contrast, five or all of the six calves treated prophylactically with generic LA ivermectin or doramectin, respectively, were positive for P. ovis mites at the end of the study. Calves treated prophylactically with ivermectin LAI gained significantly more weight than the untreated controls.

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“…Additional timepoints and an extra parameter ('knock-down') were monitored for Farms [11][12][13][14][15][16]. The status of the mites was recorded at 0, 5 min, 0.5, 1, 2, 4,6, 8, 24, 48, 72 and 120 hours of incubation.…”

Section: In Vitro Susceptibilitymentioning

confidence: 99%

“…Acaricides need to be applied twice with a 7-10-day interval, probably due to a lack of full ovicidal efficacy, as seen in Sarcoptes scabiei [9,10]. Long-acting (LA) ML only need one application, because of their long persistent activity [11][12][13][14][15]. Additional measures are crucial to get the desired treatment result.…”

Section: Introductionmentioning

confidence: 99%

Resistance against macrocyclic lactones in Psoroptes ovis in cattle

Mol

Wilde

Casaert

et al. 2019

Preprint

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BackgroundPsoroptic mange is an important disease in beef cattle, and Belgian Blue cattle are particularly susceptible. Treatment failure of macrocyclic lactones against Psoroptes ovis has been reported, but clear evidence of in vivo resistance is still lacking. This study was conducted to investigate ML efficacy in 16 beef farms in Belgium and The Netherlands in vivo and in vitro. MethodsOn each farm a group of animals (n= 7-14) with clinical psoroptic mange was treated with two subcutaneous injections of a macrocyclic lactone with 7-10 days interval (15 farms) or a single injection with a long-acting macrocyclic lactone (1 farm). In vivo efficacy was assessed by the reduction in mite counts and clinical index (part of the body affected by lesions), the cure rate after the first treatment round and the number of treatment rounds needed to cure all animals. In vitro knock-down and mortality was evaluated in a contact test. ResultsCure rates after the first treatment round varied from 0-80%. All farms needed two or more rounds of treatments to obtain full efficacy. Clinical index had a high variation and only started to reduce after the second treatment round. Only three farms were categorized as susceptible with a mean mite count reduction>95% and a lower limit of the uncertainty interval>90%. One farm had a mean reduction>95%, but its lower limit of the confidence interval was <90%. All other farms had mean reductions<95% and lower limits of their uncertainty intervals<90%. No correlation was found between in vitro lethal dose 50 and knock-down dose 50 values and any parameter of in vivo efficacy. ConclusionUnambiguous treatment failure was detected on 12/16 beef farms, confirming the presence of macrocyclic lactone resistance in Belgian Blue beef farms. In vitro parameters could not discriminate the farms based on their in vivo susceptibility. The mean reduction in mite counts and the lower limit of the confidence interval stood out as most useful parameter to identify acaricide resistance.

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Efficacy of a long-acting formulation of ivermectin against Psoroptes ovis (Hering, 1838) on cattle

Cited by 18 publications

References 19 publications

Activity of ivermectin long-acting injectable (IVOMEC® GOLD) in first-season grazing cattle exposed to natural challenge conditions in Germany

Activity of ivermectin long-acting injectable (IVOMEC® GOLD) in first-season grazing cattle exposed to natural challenge conditions in Germany

Efficacy of a new long-acting formulation of ivermectin and other injectable avermectins against induced Psoroptes ovis infestations in cattle

Resistance against macrocyclic lactones in Psoroptes ovis in cattle

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