Efficacy of 5-Aminolevulinic Acid Photodynamic Therapy in treatment of nasal inverted papilloma

Zhang, Yunjie; Yang, Yuguang; Zou, Xianbiao

doi:10.1016/j.pdpdt.2013.05.010

Cited by 11 publications

(16 citation statements)

References 4 publications

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“…Photodynamic therapy using 5-aminolevulinic acid has been described recently 40 . Cotton wool soaked in 5-aminolevulinic acid was applied for 4 hours before the tissue was irradiated with 635 nm wavelength light.…”

Section: Discussionmentioning

confidence: 99%

Management of inverted papilloma: review

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Management of inverted papilloma: review

et al. 2017

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“…Under 635nm laser irradiation, it generates singlet oxygen and other active oxides, which can damage cell membranes, mitochondria, and DNA, cause cell necrosis and apoptosis, and then kill diseased cells. 12 , 13 In recent years, some researchers have found that PDT shows efficacy by activating local specific immunity. 14 , 15 Brotosik et al found that PDT resulted in apoptosis of epidermal keratinocytes and Langerhans cells.…”

Section: Discussionmentioning

confidence: 99%

A case series pilot study on the combination of 5-aminolevulinic acid and photodynamic therapy (ALA-PDT) for treatment of vitiligo

Zhang

Lin

Guo

et al. 2018

An. Bras. Dermatol.

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BackgroundTo study the effective therapeutic concentration, drug application duration, irradiation duration and irradiation dosage of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for treating vitiligo and observe its clinical efficacy.ObjectiveTo assess the clinical efficacy of ALA-PDT for treating vitiligo.MethodsALA with different drug concentrations, drug application durations, irradiation durations and irradiation dosages were adopted to treat skin lesions caused by vitiligo to determine the effective drug concentration, drug application duration, irradiation duration and irradiation dosage for treating three vitiligo volunteers and observe the therapeutic results.ResultsThe clinical trial suggested that ALA at a drug concentration of 1.5%, drug application duration for 3 hours, irradiation dosage of 80mw/cm2 and irradiation duration for 20 min was effective in treating vitiligo. Under these parameters, ALA-PDT was effective to the three vitiligo volunteers, with mild pain and feeling of burning but no other adverse reaction during treatment.Study limitationsDue to the small sample size in this study for the effectiveness of PDT in treating vitiligo and the potential variations in the efficacy for treating the disease at different areas, further studies shall be conducted for confirmation.ConclusionsALA with a drug concentration at 1.5%, drug application duration for 3 hours, irradiation dosage of 80 mw/cm2 and irradiation duration for 20 min is effective in treating vitiligo. Therefore, ALA-PDT is safe and effective in treating the disease, with minor adverse events, providing a new method for treating vitiligo in the future.

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“…In China, it was approved to be applied in the treatment of condyloma acuminatum and later adopted to treat diseases such as acne, laryngeal papilloma, nasal inverted papilloma, and solar keratosis. 4 - 6 In 1991, Gu Ying et al. reported the application of PDT in the treatment of PWS for the first time, achieving a satisfactory result.…”

Section: Discussionmentioning

confidence: 99%

Hemoporfin-mediated photodynamic therapy for the treatment of port-wine stain birthmarks in pediatric patients

Zhang

Jiang

Chen

et al. 2017

An. Bras. Dermatol.

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Port-wine stain is a type of common congenital superficial telangiectasia in the dermal layer mostly occurring on the forehead, face, and neck. The affected skin shows abnormal red or purple lesions, which darken and thicken. Nodular changes may develop with advancing age. If untreated, port-wine stains scarcely regress, which can have serious lifelong psychological impact on patients and affect their quality of life. In this report, we focused on two cases of port-wine stain in pediatric patients; the youngest patient was only 1.5 years old. During and after treatment, Hemoporfin-mediated photodynamic therapy features fewer adverse reactions, short light protection period, easy nursing, and good efficacy.

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Efficacy of 5-Aminolevulinic Acid Photodynamic Therapy in treatment of nasal inverted papilloma

Cited by 11 publications

References 4 publications

Management of inverted papilloma: review

Management of inverted papilloma: review

A case series pilot study on the combination of 5-aminolevulinic acid and photodynamic therapy (ALA-PDT) for treatment of vitiligo

Hemoporfin-mediated photodynamic therapy for the treatment of port-wine stain birthmarks in pediatric patients

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