A case series pilot study on the combination of 5-aminolevulinic acid and photodynamic therapy (ALA-PDT) for treatment of vitiligo

Zhang, YunJie; Lin, Hongyuan; Guo, Xiaomao; Zou, Xianbiao

doi:10.1590/abd1806-4841.20187014

Cited by 10 publications

(9 citation statements)

References 17 publications

(19 reference statements)

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“…In a preliminary analysis of photodynamic therapy with 5-aminolevulinic acid (ALA) in treating vitiligo, 3 patients were treated with ALA at a drug concentration of 1.5%, applied for 3 hours before irradiation with UV-A at 80mw/cm2 for 20 min and was effective in treating vitiligo. The treatment was associated with mild pain and burning sensation, but no other adverse reaction was noted [106].…”

Section: Photodymanic Therapymentioning

confidence: 87%

Emerging drugs for the treatment of vitiligo

Karagaiah

Valle

Sigova

et al. 2020

Expert Opinion on Emerging Drugs

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Introduction: Vitiligo is a relatively common autoimmune depigmenting disorder of skin. There has been a great advance in understanding the pathological basis, which has led to development and utilisation of various new molecules in treating vitiligo.This review aims at a comprehensively describing the treatments available and the emerging treatment aspects and the scope for future developments.Areas covered: This study comprehensively summarises the current concepts in the pathogenesis of vitiligo with special focus on the cytokine and signalling pathways, which are the targets for newer drugs. JAK kinase signalling pathways and the cytokines involved are the focus of vitiligo treatment in current research, followed by antioxidant mechanisms and repigmenting mechanisms. Topical immunosuppressants may be an alternative to steroids in localised vitiligo. Newer repigmenting agents like basic fibroblast growth factors, afamelanotide have been included and a special emphasis is laid on the upcoming targeted immunotherapy. Expert opinion:The treatment of vitiligo needs to be multimodal with emphasis on targeting different limbs of the pathogenesis. Topical and oral JAK inhibitors are the most promising new class of drugs currently available for treating vitiligo and acts best in conjunction with NB-UVB.

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Section: Photodymanic Therapymentioning

confidence: 87%

Emerging drugs for the treatment of vitiligo

Karagaiah

Valle

Sigova

et al. 2020

Expert Opinion on Emerging Drugs

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“…On the other hand, in a number of studies, the effectiveness of PDT in the treatment of vitiligo has been demonstrated. Zhang et al treated vitiligo lesions with 1.5% 5-ALA, followed by 80 mw/cm 2 red light irradiation and found that 5-ALA-PDT effectively repigments vitiligo patches to some extent [ 104 ]. Similarly, Serrano and colleagues reported some degree of repigmentation in vitiligo lesions treated with PDT [ 105 ].…”

Section: Photodynamic Therapy Applicationsmentioning

confidence: 99%

“…Mono- and di-selenide-containing polymers are insoluble in aqueous solutions and are used in the fabrication of amphiphilic block copolymers. Telluride is less toxic and more sensitive to ROS than selenide and sulfide due to its lower electronegativity which make it a suitable composition in design and synthesis of copolymers and polymers for drug delivery systems and ROS-responsive prodrug preparation [ 104 ]. The prodrugs consisted of three domains, a ROS acceptor that can be sensitive to ROS, an effector that is the native drug part, and a linker between the ROS acceptor and the effector.…”

Section: Ros-responsive Materials Along With Pdt For Skin Wound Healingmentioning

confidence: 99%

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Accelerating skin regeneration and wound healing by controlled ROS from photodynamic treatment

et al. 2022

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Cellular metabolisms produce reactive oxygen species (ROS) which are essential for cellular signaling pathways and physiological functions. Nevertheless, ROS act as “double-edged swords” that have an unstable redox balance between ROS production and removal. A little raise of ROS results in cell proliferation enhancement, survival, and soft immune responses, while a high level of ROS could lead to cellular damage consequently protein, nucleic acid, and lipid damages and finally cell death. ROS play an important role in various pathological circumstances. On the contrary, ROS can show selective toxicity which is used against cancer cells and pathogens. Photodynamic therapy (PDT) is based on three important components including a photosensitizer (PS), oxygen, and light. Upon excitation of the PS at a specific wavelength, the PDT process begins which leads to ROS generation. ROS produced during PDT could induce two different pathways. If PDT produces control and low ROS, it can lead to cell proliferation and differentiation. However, excess production of ROS by PDT causes cellular photo damage which is the main mechanism used in cancer treatment. This review summarizes the functions of ROS in living systems and describes role of PDT in production of controllable ROS and finally a special focus on current ROS-generating therapeutic protocols for regeneration and wound healing.

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“…These observations may partially explain why PDT did not achieve brilliant results in treatment of vitiligo in pediatric patients. Zhang et al (2018 ) conducted a study to determine the effective PS concentration, PS application duration, irradiation duration, and irradiation dosage for the treatment of vitiligo. They selected ALA concentration of 1.5%, PS application duration of 3 h, irradiation duration of 20 min, and irradiation dosage of 80 mw/cm 2 as the better parameters for treating their patients.…”

Section: Miscellaneamentioning

confidence: 99%

Photodynamic therapy in pediatric age: Current applications and future trends

et al. 2022

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Photodynamic therapy (PDT) is a photochemotherapy based on local application of a photosensitive compound and subsequent exposure to a light source of adequate wavelength. It is a non-invasive therapeutic procedure widely used in oncodermatology for treatment of numerous skin cancers, but in the last years its use has been gradually extended to an increasing list of skin diseases of both infectious and inflammatory nature. Although PDT is proven as a safe and effective therapeutic option in adults, its use is not well standardized in the pediatric population. In this review, we will focus on clinical applications, mechanisms of action, protocols, and adverse events in children and adolescents. Most of pediatric experiences concerned treatment of skin cancers in Gorlin syndrome and xeroderma pigmentosum, acne vulgaris, and viral warts, but other applications emerged, such as cutaneous lymphoma and pseudo-lymphomas, necrobiosis lipoidica, hidradenitis suppurativa, dissecting cellulitis, leishmaniasis, angiofibromas, verrucous epidermal nevus, and linear porokeratosis. In these pediatric diseases, PDT appeared as an effective therapeutic alternative. The results on vitiligo were limited and not fully encouraging. Although highly versatile, PDT is not a therapy for all skin diseases, and a deeper knowledge of its mechanisms of action is required to better define its spectrum of action and safety in pediatric patients.

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A case series pilot study on the combination of 5-aminolevulinic acid and photodynamic therapy (ALA-PDT) for treatment of vitiligo

Cited by 10 publications

References 17 publications

Emerging drugs for the treatment of vitiligo

Emerging drugs for the treatment of vitiligo

Accelerating skin regeneration and wound healing by controlled ROS from photodynamic treatment

Photodynamic therapy in pediatric age: Current applications and future trends

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