Efficacy of 10% whole Azadirachta indica (neem) chip as an adjunct to scaling and root planning in chronic periodontitis: A clinical and microbiological study

Vennila, K; Elanchezhiyan, S; Ilavarasu, Sugumari

doi:10.4103/0970-9290.179808

Cited by 24 publications

(23 citation statements)

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“…Similar results were obtained using bark and twigs of the tree (Chaurasia, 2016;Geethashri, Manikandan, Ravishankar, & Shetty, 2014;Sundaram, Narayanan, & Vadakkepurayil, 2016). Moreover, nonabsorbable A. indica oil chip (10%) showed significant antibacterial properties against Porphyromonas gingivalis, a periodontal pathogen (Vennila, Elanchezhiyan, & Ilavarasu, 2016).…”

Section: Antibacterial Activitysupporting

confidence: 60%

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A comprehensive review of phytochemical profile, bioactives for pharmaceuticals, and pharmacological attributes of Azadirachta indica

Saleem

Muhammad

Hussain

et al. 2018

Phytotherapy Research

120

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Azadirachta indica L. is a multipurpose medicinal tree of family Meliaceae. It occurs in tropical and semitropical regions of the world. Different parts of this miraculous tree are used to treat pyrexia, headache, ulcer, respiratory disorders, cancer, diabetes, leprosy, malaria, dengue, chicken pox, and dermal complications. The tree is popular for its pharmacological attributes such as hypolipidemic, antifertility, microbicidal, antidiabetic, anti-inflammatory, hepatoprotective, antipyretic, hypoglycemic, insecticidal, nematicidal, antiulcer, antioxidant, neuroprotective, cardioprotective, and antileishmaniasis properties. A. indica is also rich in various phytochemicals for pharmaceuticals such as alkaloids, steroids, flavonoids, terpenoids, fatty acids, and carbohydrates. The fungicidal potential of the tree is due to the presence of azadirachtin and nimbin. Herein, we have compiled a comprehensive review of phytochemical profile, pharmacological attributes, and therapeutic prospective of this multipurpose tree.

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Section: Antibacterial Activitysupporting

confidence: 60%

“…Moreover, nonabsorbable A . indica oil chip (10%) showed significant antibacterial properties against Porphyromonas gingivalis , a periodontal pathogen (Vennila, Elanchezhiyan, & Ilavarasu, ).…”

Section: Pharmacological Attributesmentioning

confidence: 99%

A comprehensive review of phytochemical profile, bioactives for pharmaceuticals, and pharmacological attributes of Azadirachta indica

Saleem

Muhammad

Hussain

et al. 2018

Phytotherapy Research

120

View full text Add to dashboard Cite

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“…38,39 Nimbidin and sodium nimbidate are the major components of neem responsible for most of its pharmacological actions. 31 It was observed that 5% of neem extract was effective against gram positive and gram negative bacteria in culture medium and 10% extract yielded better results in clinical studies. 31 In one recent study conducted by a group of periodontist a 10% non-absorbable neem chip was placed in the gingiva.…”

Section: Discussionmentioning

confidence: 99%

Herbal medicine as adjunct in periodontal therapies- A review of clinical trials in past decade

Abdelmagyd

Shetty

Al-Ahmari

2019

Journal of Oral Biology and Craniofacial Research

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The aim of this paper was to analyze the literature published in the research related to herbal medicine as adjunct in periodontal therapies. An internet search using search engines-Google, Researchgate and PubMed was carried out. The keywords used for search were-periodontal therapy, adjunct, herbal, and periodontitis. Full text articles of the articles were collected from the year 2007-2017. The data available from the clinical trials the journal articles were analyzed and presented in both tabular and descriptive patterns. The herbs frequently tested used for treatment of periodontitis are Acacia catechu, Aloe vera, Azadirachta indica, Glycyrrhiza glabra, Cinnamomum zeylanicum, Allium sativum, Propolis, Mikania laevigata, Mikania glomerate, Droserapeltata, Helichrysumitalicum, Coptidis rhizome, Piper cubeba, Azadirachta indica, Syzygium Aromaticum and Tea tree oil. 8 Besides the above mentioned herbal remedies a number of other herbal based products are also undergoing

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“…Our bibliographical review process covered a total of 16 publications including three books [37][38][39], and 13 scientific articles [32,[40][41][42][43][44][45][46][47][48][49][50][51]. One reference accounted for 81.4% of the 495 ethnobotanical uses recorded [37].…”

Section: Selection Of Plantsmentioning

confidence: 99%

Antibacterial activity of plant species used for oral health against Porphyromonas gingivalis

et al. 2020

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Porphyromonas gingivalis is the keystone pathogen of periodontitis, a chronic inflammatory disease which causes tooth loss and deterioration of gingiva. Medicinal plants have been traditionally used for oral hygiene and health and might play a role as antibacterial agents against oral pathogens. In this work, we aimed to evaluate the antibacterial activity of plants used for oral hygiene or symptoms of periodontitis against P. gingivalis. We first reviewed the literature to identify plant species used for oral hygiene or symptoms of periodontitis. Then, we cross-checked this species list with our in-house library of plant extracts to select extracts for testing. Antibacterial activity tests were then performed for each plant extract against P. gingivalis, and their cytotoxicity was assessed on HaCaT cells. The selectivity index (SI) was then calculated. A total of 416 plant species belonging to 110 families and 305 genera were documented through our literature search, and 158 plant species were noted as being used by North American Native peoples Once cross-checked with the extracts contained in our library of natural products, 30 matches were identified and 21 were defined as high priority. Of the 109 extracts from 21 plant species selected and tested, 21 extracts from 11 plants had higher than 90% inhibition on P. gingivalis at 64 μg/mL and were further selected for MIC (Minimum Inhibitory Concentration) assays. Out of 21 plant extracts, 13 extracts (7 plant species) had a SI > 10. Pistacia lentiscus fruits showed the best MIC with value of 8 μg/mL, followed by Zanthoxylum armatum fruits/seeds with a MIC of 16 μg/mL. P. lentiscus fruits also showed the highest SI of 256. Most of the extracts tested present promising antibacterial activity and low cytotoxicity. Further testing for biofilm eradication and examination of activity against other dental pathogens and oral commensals should be performed to confirm the potential of these extracts as antibacterial agents. Future work will focus on application of a bioassay-guided fractionation approach to isolating and identifying the most active natural products in the top performing extracts. This study can serve as a basis for their future development as ingredients for oral hygiene products.

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Efficacy of 10% whole Azadirachta indica (neem) chip as an adjunct to scaling and root planning in chronic periodontitis: A clinical and microbiological study

Abstract: Hence, 10% neem oil local delivery system delivers desired effects on P. gingivalis. Further research is needed to evaluate the neem oil efficacy on other periodontal pathogens.

Cited by 24 publications

References 1 publication

A comprehensive review of phytochemical profile, bioactives for pharmaceuticals, and pharmacological attributes of Azadirachta indica

A comprehensive review of phytochemical profile, bioactives for pharmaceuticals, and pharmacological attributes of Azadirachta indica

Herbal medicine as adjunct in periodontal therapies- A review of clinical trials in past decade

Antibacterial activity of plant species used for oral health against Porphyromonas gingivalis

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