Efficacy of 1.23% acidulated phosphate fluoride gel on non-cavitated enamel lesions: a randomized clinical trial

Abstract

A randomized controlled parallel clinical trial was conducted to evaluate the efficacy of the association of 1.23% topical professional acidulated phosphate fluoride (APF) gel with oral hygiene and dietary instructions on the arrest of active non-cavitated lesions in permanent, mixed, and temporary dentition in children between 3 and 12 years of age. Ninety-eight caries-active children were randomly divided into two groups: a fluoride gel group (n = 49) and a non-fluoridated gel group (n = 49). Each group received up to eight weekly applications of gel, weekly professional toothbrushing with oral hygiene instructions and dietary counselling. Caries lesions were assessed qualitatively through visual-tactile criteria performed in three stages: initial, intermediate, and final. Regression models were applied to identify risk indicators for caries control. Between-group comparison regarding the time taken to arrest the lesions was performed using Chi-squared and Fisher's exact tests. Seventeen children did not receive the allocated intervention, and one was lost to follow-up (n = 80). There was no difference between the control and placebo groups regarding the time to the arrest of the lesion (p >.05). The treatments showed similar results without significant statistical difference (p = 0.33; 95%CI: 0.32-1.48). No adverse effects were observed. It can be concluded that no additional effect of the association of 1.23% APF gel with oral hygiene using fluoride dentifrice and dietary instructions on the arrest of active non-cavitated lesions could be established. We can also confirm the importance of toothbrushing frequency and, consequently, the visible plaque reduction in the control of caries activity. RBR-37V5S3

Bioactive Materials for Caries Management: A Literature Review

“…Acidulated fluorophosphate gel is the most commonly used professional topically applied fluoride gel [ 46 , 59 ]. However, topical application of acidulated fluorophosphate gel has no additional arresting effect on caries lesions [ 24 ]. Stannous fluoride has more antimicrobial properties than other fluoride compounds do [ 65 , 66 ].…”

Acidulated phosphate fluoride sebagai bahan pencegahan Karies gigi anak : a scoping review (Laporan Penelitian)

“…Prevalensi karies pada tahun 2018 mengalami peningkatan dua kali lipat lebih dari tahun dari tahun 2013 yaitu 25,9% menjadi 57,6%. 3 Beberapa faktor terlibat dalam pencegahan karies gigi pada anak. Salah satu faktor yang paling efektif adalah penggunaan fluorida yang tepat.…”

“…APF adalah agen kariostatik yang pertama kali diperkenalkan oleh Brudevold, et al pada tahun 1963. 3 Acidulated Phosphate Fluoride merupakan salah satu bahan fluorida yang dapat diaplikasikan secara topikal dan paling efektif dalam meningkatkan pelepasan fluor oleh material restorasi jika dibandingkan dengan bahan topikal aplikasi fluor lainnya.6 Aplikasi gel APF akan membentuk fluorapatit yang lebih tahan asam dan membantu proses remineralisasi pada email gigi. Email gigi sulung memiliki derajat porositas yang lebih tinggi, mengandung mineral kalsium dan fosfat yang lebih sedikit.…”

“…Pentingnya, frekuensi menyikat gigi dan pengurangan plak dalam mengendalikan aktivitas karies. 41 Penelitian Maria Laura Menezes Bonow, et al pada tahun 2012 dengan 60 sampel (anak-anak usia 7-12 tahun) yang bertujuan untuk mengevaluasi efektivitas aplikasi gel 1,23% APF pada penangkapan lesi karies aktif yang baru terbentuk pada anak-anak. Hasil dari penelitian ini, tidak menunjukkan efek tambahan dari APF gel pada sampel anak-anak yang terpapar air fluorida dan pasta gigi ini dalam pencegahan lesi email dibandingkan dengan gel plasebo setelah 8 minggu.…”

Unemployment and expenditure on health and education as mediators of the association between toothbrushing and global income inequalities

“…Infrequent toothbrushing is associated with greater caries incidence and increment in primary and permanent teeth [1]. Frequent toothbrushing reduces plaque accumulation and caries activity [2]. Less than twice daily toothbrushing at two and three years of age is associated with more caries at the age of 5 [3].…”