Efficacy comparison of lyophilised black raspberries and combination of celecoxib and PBIT in prevention of carcinogen-induced oesophageal cancer in rats

Shi, Ning; Riedl, Ken M.; Schwartz, Steven J.; Zhang, Xiaoli; Clinton, Steven K.; Chen, Tong

doi:10.1016/j.jff.2016.08.044

Cited by 16 publications

(19 citation statements)

References 36 publications

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“…Our previous study showed the significant chemoprevention effects of strawberry in CRC mouse model and its role in inflammation inhibition [18]. We also demonstrate that black raspberry inhibits oxidative stress, the inflammation mediators, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and exhibits superior anti-cancer effects than inhibitors of COX-2 and iNOS in an animal model [21,22]. In this review, we summarize the roles of strawberry, black raspberry, and their polyphenol components on CRC chemoprevention in IBD.…”

Section: Introductionmentioning

confidence: 92%

“…Anthocyanins are flavonoid compounds that are responsible for the colors of most fruits and vegetables, and they contribute to the protective effects of fruits and vegetables against chronic diseases and cancer (Figure 2). According to our previous studies, anthocyanins are the main components in strawberry and black raspberry (Table 2) [18,22]. Among the anthocyanins, cyanidin rutinoside is the most abundant in black raspberry, whereas pelargonidin glucoside is the most abundant in strawberry.…”

Section: Chemoprevention Of Colorectal Cancer In Inflammatory Bowementioning

confidence: 99%

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Chemopreventive Effects of Strawberry and Black Raspberry on Colorectal Cancer in Inflammatory Bowel Disease

2019

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Colorectal cancer (CRC) remains the third most common cause of cancer-related death in the United States and the fourth globally with a rising incidence. Inflammatory bowel disease (IBD) is a chronic immunologically mediated disease that imposes a significant associated health burden, including the increased risk for colonic dysplasia and CRC. Carcinogenesis has been attributed to chronic inflammation and associated with oxidative stress, genomic instability, and immune effectors as well as the cytokine dysregulation and activation of the nuclear factor kappa B (NFκB) signaling pathway. Current anti-inflammation therapies used for IBD treatment have shown limited effects on CRC chemoprevention, and their long-term toxicity has limited their clinical application. However, natural food-based prevention approaches may offer significant cancer prevention effects with very low toxicity profiles. In particular, in preclinical and clinical pilot studies, strawberry and black raspberry have been widely selected as food-based interventions because of their potent preventive activities. In this review, we summarize the roles of strawberry, black raspberry, and their polyphenol components on CRC chemoprevention in IBD.

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Section: Introductionmentioning

confidence: 92%

Section: Chemoprevention Of Colorectal Cancer In Inflammatory Bowementioning

confidence: 99%

Chemopreventive Effects of Strawberry and Black Raspberry on Colorectal Cancer in Inflammatory Bowel Disease

2019

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“…Dracorhodin perchlorate (DP), a synthetic analog of the anthocyanin red pigment dracorhodin, exerts various pharmacological effects, including anti-cancer activity in human ESCC cells due to G 2 /M phase cell cycle arrest through upregulation of p21 and p27, and downregulation of cyclin B1 and Cdc2 [208]. Importantly, anthocyanins are superior to the combination of celecoxib, a selective COX-2 inhibitor, and S,S'-1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea (PBIT), a selective iNOS inhibitor, in suppressing carcinogen-induced ESCC in rats [209].…”

Section: Esophageal Cancermentioning

confidence: 99%

Chemopreventive Effect of Dietary Anthocyanins against Gastrointestinal Cancers: A Review of Recent Advances and Perspectives

Dharmawansa

Hoskin

Rupasinghe

2020

IJMS

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Anthocyanins are a group of dietary polyphenols, abundant mainly in fruits and their products. Dietary interventions of anthocyanins are being studied extensively related to the prevention of gastrointestinal (GI) cancer, among many other chronic disorders. This review summarizes the hereditary and non-hereditary characteristics of GI cancers, chemistry, and bioavailability of anthocyanins, and the most recent findings of anthocyanin in GI cancer prevention through modulating cellular signaling pathways. GI cancer-preventive attributes of anthocyanins are primarily due to their antioxidative, anti-inflammatory, and anti-proliferative properties, and their ability to regulate gene expression and metabolic pathways, as well as induce the apoptosis of cancer cells.

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“…They were frozen and stored at -20ºC. Before the analysis they were defrosted, dried at 40ºC and grounded on a domestic mill [7].…”

Section: Sample Preparationmentioning

confidence: 99%

“…Raspberries are known for their antitumoral, antibacterial, antiinfamatory [6,7] and antioxidant activities [8].…”

Section: Introductionmentioning

confidence: 99%

Identification and Quantification of Phenolic Compounds from Red Currant (Ribes rubrum L.) and Raspberries (Rubus idaeus L.)

Frum

Georgescu

Gligor

et al. 2017

IJPPE

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Abstract. The extracts obtained from two types of berries: red currant and raspberries, were evaluated for their phenolic content. They were identified and quantified by using an optimized HPLC method. During the analyze several phenolic compounds were found, like: gallic acid, (+)-catechin, syringic acid, cinnamic acid, chlorogenic acid, ferulic acid, rutin and quercetin. The total amount of phenolic compounds analyzed found in red currant was greater than the one found in raspberries, due to the low variety of phenolic compounds extracted. The greatest amount of gallic acid, (+)-catechin, syringic acid, cinnamic acid, chlorogenic acid, ferulic acid and rutin was determined from the extraction of red currant berries and the raspberries extract contained the greatest source of quercetin. This study shows that red currant can provide the highest and most varied content of phenolic compounds from the analyzed berries.

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Efficacy comparison of lyophilised black raspberries and combination of celecoxib and PBIT in prevention of carcinogen-induced oesophageal cancer in rats

Cited by 16 publications

References 36 publications

Chemopreventive Effects of Strawberry and Black Raspberry on Colorectal Cancer in Inflammatory Bowel Disease

Chemopreventive Effects of Strawberry and Black Raspberry on Colorectal Cancer in Inflammatory Bowel Disease

Chemopreventive Effect of Dietary Anthocyanins against Gastrointestinal Cancers: A Review of Recent Advances and Perspectives

Identification and Quantification of Phenolic Compounds from Red Currant (<i>Ribes</i> <i>rubrum</i> L.) and Raspberries (<i>Rubus</i> <i>idaeus</i> L.)

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