Chemopreventive Effects of Strawberry and Black Raspberry on Colorectal Cancer in Inflammatory Bowel Disease

Chen, Tong; Shi, Ning; Afzali, Anita

doi:10.3390/nu11061261

Cited by 36 publications

(31 citation statements)

References 104 publications

(167 reference statements)

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“…Inflammation-induced carcinogenesis has been shown to be associated with oxidative stress, genomic instability, immune effectors, cytokine dysregulation and the modulation of the NF-κB signaling pathway. Foods such as strawberries and black raspberries have been shown to play a synergistic role in multiple molecular events, including the suppression of cytokine release, the reduction of oxidative stress, the reduction of genomic instability and the inhibition of NF-κB and related pathways (38).…”

Section: Colon Cancermentioning

confidence: 99%

Polyphenols in cancer prevention: New insights (Review)

et al. 2020

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A huge volume of literature data suggests that a diet rich in fruits and vegetables, mostly due to the contribution of natural polyphenols, could reduce the incidence of specific cancers. Resveratrol, epigallocatechin gallate and curcumin are among the most extensively studied polyphenols: The majority of the effects attributed to these compounds are linked to their antioxidant and anti-inflammatory properties. The multiple mechanisms involved include the modulation of molecular events and signaling pathways associated with cell survival, proliferation, differentiation, migration, angiogenesis, hormonal activities, detoxification enzymes and immune responses. Notwithstanding their promising role in cancer prevention and treatment, polyphenols often have a poor bioavailability when administered as pure active principles, representing an important limit to their use. However, the bioavailability and thus the efficacy of these compounds can be improved by their administration in combination with other phytochemicals, with anticancer drugs or in polyphenol-loaded nanotechnology-based delivery systems. The possibility of combining conventional drugs with polyphenols offers very valuable advantages, such as the building of more efficient anticancer therapies with less side-effects on the health of patients. The present review focuses on current knowledge regarding the interactions between natural polyphenols and cancer development in order to gain a clearer comprehension of the potential mechanisms through which individual foods and food components may be exploited to reduce cancer risk. Contents 1. Introduction 2. Literature search 3. Classification of polyphenols 4. Prostate cancer 5. Colon cancer 6. Breast cancer 7. Lung cancer 8. Bladder cancer 9. Skin cancer 10. Pancreatic cancer 11. Leukemia 12. Conclusion

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Section: Colon Cancermentioning

confidence: 99%

Polyphenols in cancer prevention: New insights (Review)

et al. 2020

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“…Most dietary antioxidants are derived from eating vegetables, fruits, tea and wine, foods markedly rich in phenolic compounds [ 44 , 45 ]. The decrease in diseases, such as cancer, cardiovascular disease, amongst others, is attributed to the regular consumption of fruit and vegetables which contain natural antioxidants [ 46 , 47 ].…”

Section: The Impact Of Oxidative Stress On Human Healthmentioning

confidence: 99%

Phenolic Compounds Impact on Rheumatoid Arthritis, Inflammatory Bowel Disease and Microbiota Modulation

et al. 2021

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Non-communicable chronic diseases (NCDs) are nowadays the principal cause of death, especially in most industrialized nations. These illnesses have increased exponentially with the consumption of diets very high in fat and sugar, not to mention stress and physical inactivity among other factors. The potential impact of suboptimal diets on NCDs’ morbidity and mortality rates brings to the forefront the necessity for a new way of improving dietary habits. The literature provides extensive scientific work that presents evidence that phenolic compounds from diets have antioxidant, anti-inflammatory and antiproliferative activities that impact human health. Gut microbiota modulation by some phenolic compounds leads to favorable changes in abundance, diversity, and in the immune system. However, polyphenol’s limited bioavailability needs to be overcome, highlighting their application in new delivery systems and providing their health benefits in well-established ways such as health maintenance, treatment or adjuvant to conventional pharmacological treatments. In this context, novel dietary approaches, including new food supplements, have emerged to prevent diseases and preserve health.

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“…The chemoprotective action of strawberries was also studied by Casto et al [92] (results not presented in Table 4 as authors used commercial strawberry powder). The chemoprotective role of strawberries on colorectal cancer in inflammatory bowel disease was recently reviewed by Chen et al [93], who proposed a mechanism of action involving the suppression of cytokines release, decrease of oxidative stress, reduction of genomic instability, and inhibition of NFκB (nuclear factor kappa-light-chain-enhancer of activated B cells) and related signalling pathways. Table 4 summarizes the main biological activities (except anti-oxidant properties, presented in Table 3), as emerging from the literature survey, considering the main constituents of the tested extracts.…”

Section: Other Potential Applicationsmentioning

confidence: 99%

Fragaria Genus: Chemical Composition and Biological Activities

et al. 2020

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The strawberries represent in our days one of the main fresh fruits consumed globally, inevitably leading to large amounts of by-products and wastes. Usually appreciated because of their specific flavor, the strawberries also possess biological properties, including antioxidant, antimicrobial, or anti-inflammatory effects. In spite of the wide spread of the Fragaria genus, few species represent the subject of the last decade scientific research. The main components identified in the Fragaria species are presented, as well as several biological properties, as emerging from the scientific papers published in the last decade.

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Chemopreventive Effects of Strawberry and Black Raspberry on Colorectal Cancer in Inflammatory Bowel Disease

Cited by 36 publications

References 104 publications

Polyphenols in cancer prevention: New insights (Review)

Polyphenols in cancer prevention: New insights (Review)

Phenolic Compounds Impact on Rheumatoid Arthritis, Inflammatory Bowel Disease and Microbiota Modulation

Fragaria Genus: Chemical Composition and Biological Activities

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