Efficacy and toxicity of (chemo)radiotherapy for primary subglottic cancer

Hata, Masaharu; Taguchi, Takahide; Koike, Izumi; Nishimura, Goshi; Takahashi, Masahiro; Komatsu, Masanori; Sano, Daisuke; Odagiri, Kazumasa; Minagawa, Y.; Inoue, Tomio

doi:10.1007/s00066-012-0178-0

Cited by 16 publications

(18 citation statements)

References 28 publications

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“…Results of some studies regarding treatment of subglottic carcinoma with radiotherapy or chemoradiotherapy are listed in Table 2. 2,4,[13][14][15][16][17][18][19][20][21][22][24][25][26] Similarly, Paisley et al 17 treated 43 patients with subglottic carcinoma with radiotherapy alone. Twenty patients had T3 or T4 tumors, and local control was achieved in 24 of 43 patients (54%).…”

Section: Prognosis and Treatment Results Of Subglottic Carcinomamentioning

confidence: 99%

“…Radiation fields for advanced‐stage cases usually include the larynx, bilateral cervical, supraclavicular, and upper mediastinal lymph nodes. Total dose ranges between 50 and 75 Gy …”

Section: Treatmentmentioning

confidence: 99%

“…The reported incidence of subglottic carcinoma in some series varies between 0.013% and 6%. 2,[13][14][15][16][17][18][19][20][21][22] Some of the series reporting on the incidence of subglottic squamous cell carcinoma are listed in Table 1. 2,[13][14][15][16][17][18][19][20][21][22] 5 | TREATMENT…”

Section: Epidemiologymentioning

confidence: 99%

“…Total dose ranges between 50 and 75 Gy. 4,17,21 Lymphatic vessels of the subglottic region drain into the prelaryngeal (Delphian), pretracheal, and paratracheal lymph nodes, 8,9 and proper management of these lymph nodes along with the primary tumor is of utmost importance. It is generally believed that the prelaryngeal lymph node (Delphian node) is specific to subglottic carcinoma.…”

Section: Overview Of Treatmentmentioning

confidence: 99%

“…The reported incidence of subglottic carcinoma in some series varies between 0.013% and 6% . Some of the series reporting on the incidence of subglottic squamous cell carcinoma are listed in Table …”

Section: Epidemiologymentioning

confidence: 99%

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Prognosis of subglottic carcinoma: Is it really worse?

et al. 2018

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It is traditionally accepted that subglottic carcinoma has a worse prognosis than tumors arising in other subsites of the larynx, owing to its tendency to present in advanced stages, with a high incidence of cartilage invasion and extralaryngeal spread. The incidence of subglottic carcinoma varies among series, mainly because there is no uniform definition of the upper boundary of the subglottis. The extent of the tumor may be difficult to define because subglottic carcinoma may spread through the submucosa without visible mucosal changes. There is also a rich lymphatic network in the subglottis draining to the prelaryngeal and paratracheal lymph nodes, which are usually not involved by cancers arising in other laryngeal subsites. Current literature data indicates that early-stage subglottic carcinoma can be treated using radiotherapy or chemoradiotherapy with high locoregional control and survival rates. In advanced stage subglottic carcinoma, combination of surgery followed by radiotherapy or chemoradiotherapy resulted in comparable outcomes, as in advanced carcinomas from the rest of the larynx. Stage for stage, it is likely that the prognosis for subglottic carcinoma and of glottic and supraglottic cancers is similar.

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Section: Prognosis and Treatment Results Of Subglottic Carcinomamentioning

confidence: 99%

“…Radiation fields for advanced‐stage cases usually include the larynx, bilateral cervical, supraclavicular, and upper mediastinal lymph nodes. Total dose ranges between 50 and 75 Gy …”

Section: Treatmentmentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

Section: Overview Of Treatmentmentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

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Prognosis of subglottic carcinoma: Is it really worse?

et al. 2018

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Larynx Cancer

Holliday

Smith

Gross

et al. 2018

The American Cancer Society's Oncology in Practice

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Does Subglottic Squamous Cell Carcinoma Warrant a Different Strategy Than Other Laryngeal Subsites?

et al. 2020

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Objectives/Hypothesis: Subglottic squamous cell carcinoma (SSCC) is a rare cancer with limited evidence-based treatment guidelines. This study aimed to describe the treatment patterns for SSCC and to determine which treatments provide the best overall survival. Study Design: Retrospective database review. Methods: The National Cancer Database (NCDB) was queried for patients treated for SSCC from 2004 through 2014. Overall survival (OS) rates were determined by the Kaplan-Meier method. Clinicopathologic characteristics were assessed by univariable and multivariable Cox proportional hazards models, which corrected for age, sex, race, insurance status, income quartile, residence, Charlson-Deyo comorbidity score, facility type providing treatment, tumor grade, and clinical N and T category. Results: In this cohort of 549 patients with SSCC, the 5-year OS was 48.2%. SSCC presented at an advanced stage (American Joint Committee on Cancer stage III or IV) in 60.1% of cases; 78.3% of cases had no nodal metastases. Among only stage IV cases, multivariable analysis showed that radiotherapy (RT) (hazard ratio [HR] = 5.944; 95% confidence interval [CI]: 2.76-12.8; P < .001) and chemoradiotherapy (CRT) (HR = 2.321; 95% CI: 1.36-3.97; P = .002) were both associated with decreased 5-year OS compared to a group consisting of all surgeries. When this analysis was repeated for only stage III cases, RT (HR = 1.134; 95% CI: 0.38-3.37; P = .821) and CRT (HR = 1.784; 95% CI: 0.78-4.08; P = .170) were equivalent to surgery. Conclusions: Using the NCDB to study the largest cohort of SSCC with known staging and treatment, primary surgery may provide a better 5-year OS in advanced-stage SSCC.

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Efficacy and toxicity of (chemo)radiotherapy for primary subglottic cancer

Abstract: Radiotherapy is a safe and effective treatment for patients with primary squamous cell carcinoma of the subglottis. The use of chemotherapy together with radiotherapy may enhance treatment efficacy and contribute to larynx preservation through good local control.

Cited by 16 publications

References 28 publications

Prognosis of subglottic carcinoma: Is it really worse?

Prognosis of subglottic carcinoma: Is it really worse?

Larynx Cancer

Does Subglottic Squamous Cell Carcinoma Warrant a Different Strategy Than Other Laryngeal Subsites?

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