Efficacy and tolerability of single-dose versus six-day treatment of candidal vulvovaginitis with vaginal tablets of clotrimazole

Loendersloot, E W; Goormans, E.; Wiesenhaan, P.E.; Barthel, Petra; Branolte, J.

doi:10.1016/s0002-9378(85)80008-9

Cited by 12 publications

(2 citation statements)

References 2 publications

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“…Group A (Fluconazole): Patients took oral Fluconazole 150 mg (50 mg x3) single dose [8], Group B (Clotrimazole): Patients were trained to insert Clotrimazole 100 mg vaginal tablet once a day for six consecutive days at bedtime [9], Group C (Sertaconazole): Patients were trained to insert single Sertaconazole 500 mg vaginal tablet at bedtime [5].…”

Section: Methodsmentioning

confidence: 99%

Safety and efficacy of a new imidazole fungicide, Sertaconazole, in the treatment of fungal vulvo-vaginitis: a comparative study using Fluconazole and Clotrimazole

Roongpisuthipong¹,

Chalermchockcharoenkit²,

Sirimai³

et al. 2010

Asian Biomedicine

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Background: Sertaconazole is a new imidazole fungicide introduced for vulvo-vaginal candidiasis. It has an azole group with benzothiophene that inhibits biosynthesis of ergosterol and brings about a massive leak of cytoplasm with consequent fungal cell death. Objective: Assess the safety and efficacy of Sertaconazole in the treatment of fungal vulvo-vaginitis for comparison with Fluconazole and Clotrimazole. Subjects and methods: One-hundred eighty-eight outpatients with fungal vulvo-vaginitis were recruited at Siriraj Hospital, Thailand between August 31, 2004 and January 30, 2006. The patients were given Sertaconazole, Fluconazole, or Clotrimazole, and received vaginal swab and culture for fungus at seventh and 28th days after treatment. Results: Out of 188 cases, 177 cases were followed-up completely. Sertaconazole group included 66 cases where 35 cure, 20 fail, and 7 recurrent cases. Fluconazole group included 60 cases and had 37 cure, six fail, and 20 recurrence cases. Clotrimazole group included 55 cases and had 32 cure, nine fail and 11 recurrent cases. There were risk factors of fungal vulvo-vaginitis, including frequent micturition and small toilet shower flushing. Conclusion: Sertaconazole had similar effectiveness and less side-effect as compared with Fluconazole and Clotrimazole. It appeared to work well with lowest recurrence.

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Section: Methodsmentioning

confidence: 99%

Safety and efficacy of a new imidazole fungicide, Sertaconazole, in the treatment of fungal vulvo-vaginitis: a comparative study using Fluconazole and Clotrimazole

Roongpisuthipong¹,

Chalermchockcharoenkit²,

Sirimai³

et al. 2010

Asian Biomedicine

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“…Обе схемы перено сились пациентками хорошо. При этом спустя 4 недели после окончания лечения частота рецидивов оказа лась ниже в группе, получавшей 6-дневный курс лече ния 100 мг формой [13].…”

Section: эффективность терапии вагинальными формами клотримазолаunclassified

Antioxidant activity of natural flavonoids and their derivatives

Seidakhmetova¹,

Романова²,

Сейтембетов³

et al. 2018

Immunopathol Allergol Infectol

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Gynecologic Disorders

Sagraves¹,

Letassy²

1992

Applied Therapeutics

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Efficacy and tolerability of single-dose versus six-day treatment of candidal vulvovaginitis with vaginal tablets of clotrimazole

Cited by 12 publications

References 2 publications

Safety and efficacy of a new imidazole fungicide, Sertaconazole, in the treatment of fungal vulvo-vaginitis: a comparative study using Fluconazole and Clotrimazole

Safety and efficacy of a new imidazole fungicide, Sertaconazole, in the treatment of fungal vulvo-vaginitis: a comparative study using Fluconazole and Clotrimazole

Antioxidant activity of natural flavonoids and their derivatives

Gynecologic Disorders

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