Safety and efficacy of a new imidazole fungicide, Sertaconazole, in the treatment of fungal vulvo-vaginitis: a comparative study using Fluconazole and Clotrimazole

Roongpisuthipong, Anuvat; Chalermchockcharoenkit, Amphan; Sirimai, Korakot; Wanitpongpan, Prapat; Jaishuen, Atthapon; Foongladda, Suporn; Kongkergkiat, Nisit; Prymanee, Jeerawan

doi:10.2478/abm-2010-0054

Cited by 8 publications

(8 citation statements)

References 16 publications

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“…2,4,5-Trisubstituted imidazoles have been found to possess immense biological activities [ 55 , 56 , 57 , 58 , 59 ]. 2,4,5-Triphenyl imidazole ( 8 ) was first synthesized in 1882 from the reaction of aryl aldehyde ( 1 ) and benzyl ( 7 ) in alcoholic ammonia solution [ 60 ].…”

Section: Applications Of Tbab For the Synthesis Of Bioactive mentioning

confidence: 99%

Tetrabutylammonium Bromide (TBAB) Catalyzed Synthesis of Bioactive Heterocycles

Banik

Banerjee²,

Kaur³

et al. 2020

Molecules

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During the last two decades, tetrabutylammonium bromide (TBAB) has gained significant attention as an efficient metal-free homogeneous phase-transfer catalyst. A catalytic amount of TBAB is sufficient to catalyze various alkylation, oxidation, reduction, and esterification processes. It is also employed as an efficient co-catalyst for numerous coupling reactions. It has also acted as an efficient zwitterionic solvent in many organic transformations under molten conditions. In this review, we have summarized the recent developments on TBAB-catalyzed protocols for the efficient synthesis of various biologically promising heterocyclic scaffolds.

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Section: Applications Of Tbab For the Synthesis Of Bioactive mentioning

confidence: 99%

Tetrabutylammonium Bromide (TBAB) Catalyzed Synthesis of Bioactive Heterocycles

Banik

Banerjee²,

Kaur³

et al. 2020

Molecules

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“…However, the gravid uterus can complicate vaginal insertion, especially in the third trimester, a peak period for VC recurrence [ 10 ]. Additionally, a notable drawback of CLO vaginal tablets is their dissolution time [ 5 ]. This limitation led to the introduction of sertaconazole (SER) 300 mg vaginal ovule.…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies [ 3 , 5 , 6 , 16 ] have shown that SER is noninferior to CLO, with quicker symptom relief and similar adverse effects. Efficacy comparable to that of other topical azoles has also been noted [ 4 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Sertaconazole 300 mg versus clotrimazole 500 mg vaginal suppository for treating pregnant women with acute vaginal candidiasis: a double-blinded, randomized trial

Chayachinda,

Thamkhantho,

Rekhawasin

et al. 2024

BMC Pregnancy Childbirth

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Background Vaginal candidiasis (VC) commonly affects pregnant women. Traditionally, clotrimazole vaginal tablets (CLO) have been the cornerstone of management. However, sertaconazole ovules (SER) offer a novel topical antimycotic option. This double-blinded, randomized trial evaluated the efficacy of single-dose SER and CLO in treating acute VC during pregnancy. Methods From June 2020 to May 2021, this trial recruited pregnant women aged ≥ 18 years with VC symptoms (abnormal vaginal discharge and/or vulvar/vaginal itching) confirmed by microscopy. Participants with ≥ 4 VC episodes in the prior year, immunocompromised status, or imidazole contraindications and those who were absent at the 2-week follow-up were excluded. Participants were randomized to receive either 300 mg SER or 500 mg CLO. Evaluations 2 weeks after the initial medication administration included clinical cure (self-reported resolution of all symptoms), microscopic cure (pseudohyphal absence), patient satisfaction, side effects, and time to clinical cure. Participants with persistent VC received weekly SER doses until delivery. Assessments of recurrence and pregnancy outcomes were done. Results The analysis included 96 participants (48 per group, mean age 27.4 ± 7.4 years, gestational age at diagnosis 22.9 ± 6.4 weeks). Without statistical significance, SER achieved a higher clinical cure rate (62.5% vs 50%, p = 0.217; a mean difference of 12.5%, 95%CI: -17.5% to 42.5%; and a rate ratio of 1.25, 95%CI: 0.71 to 2.23) and a lower microscopic cure (47.9% vs. 62.5%, p = 0.151; a mean difference of -14.6%, 95%CI: -44.3% to 15.1%; and a rate ratio of 0.77, 95%CI: 0.43 to 1.37). The two groups had comparable times to clinical cure (SER: 3.1 ± 1.8 days, CLO: 3.4 ± 2.7 days; p = 0.848) and substantial satisfaction rates (SER: 66.7%, CLO: 60.4%; p = 0.753). No side effects were reported. Of 60 participants who gave birth at Siriraj Hospital, there were no significant differences in pregnancy outcomes. Repeated SER dosing eradicated symptoms and enhanced the microscopic cure rate. Recurrence was observed in four SER and two CLO participants within 1–2 months. Conclusion In the treatment of acute VC during pregnancy, 300 mg SER and 500 mg CLO exhibited comparable efficacy in terms of clinical and microscopic cure rates, satisfaction, side effects, time to clinical cure, recurrence rates, and pregnancy outcomes. Trial registration TCTR20190308004 (registration date March 8, 2019).

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“…Heterocyclic compounds containing nitrogen atoms, such as imidazoles and pyrimidines, have been reported as efficient corrosion inhibitors in a HCl solution [2][3][4]. Among these heterocyclic compounds, imidazole derivatives have attracted more attention, because of their wide biological activities, such as analgesic, fungicidal and antitumor actions [5][6][7], and corrosion inhibition properties [8][9][10][11][12][13][14][15][16]. The literature survey reveals that few imidazole derivatives act as good corrosion inhibitors.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical DFT and MD Simulation Study of Substituted Imidazoles as Novel Corrosion Inhibitors for Mild Steel

Dohare¹,

Quraishi²,

Lgaz³

et al. 2019

Port. Electrochim. Acta

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Three substituted imidazoles-2-(3-methoxyphenyl)-4,5-diphenyl-1H-imidazole (IM-1), 2,4,5-triphenyl-1H-imidazole (IM-2), and 2-(3-nitrophenyl)-4,5-diphenyl-1Himidazole (IM-3)-were synthesized, and their inhibiting action was tested using mass loss, electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization (PDP) methods. The results show that methoxy substituted imidazole performed better as a corrosion inhibitor than NO2 substituted imidazole. These findings were corroborated by density functional theory (DFT) and molecular dynamics (MD) simulations methods. IM-1 was found to exhibit maximum IE of 97.5%, at 100 mgL-1 , among the studied IMs. PDP study revealed that all the three IMs inhibitors predominantly acted as cathodic inhibitors, and the adsorption study showed that they followed Langmuir adsorption isotherm. The formation of an inhibitor film on the MS surface was confirmed by scanning electron microscopy (SEM) and atomic force microscopy (AFM). MD study revealed that binding energy and interaction energy of the inhibitors molecules on the MS surface followed the order IM-1> IM-2> IM-3. All the three IMs molecules adsorbed onto the mild steel surface by flat orientation. DFT and MD study results corroborated the experimental results.

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Safety and efficacy of a new imidazole fungicide, Sertaconazole, in the treatment of fungal vulvo-vaginitis: a comparative study using Fluconazole and Clotrimazole

Cited by 8 publications

References 16 publications

Tetrabutylammonium Bromide (TBAB) Catalyzed Synthesis of Bioactive Heterocycles

Tetrabutylammonium Bromide (TBAB) Catalyzed Synthesis of Bioactive Heterocycles

Sertaconazole 300 mg versus clotrimazole 500 mg vaginal suppository for treating pregnant women with acute vaginal candidiasis: a double-blinded, randomized trial

Electrochemical DFT and MD Simulation Study of Substituted Imidazoles as Novel Corrosion Inhibitors for Mild Steel

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