Efficacy and Tolerability of Almotriptan in Adolescents: A Randomized, Double‐Blind, Placebo‐Controlled Trial

Linder, Steven L.; Mathew, Ninan T.; Cady, Roger; Finlayson, Gary; Ishkanian, Gary; Lewis, Donald W.

doi:10.1111/j.1526-4610.2008.01138.x

Cited by 98 publications

(56 citation statements)

References 28 publications

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“…8 Almotriptan is approved by the Food and Drug Administration for acute migraine therapy in adolescents. 40 Several other triptans have been studied in adolescents and children and used off-label, most notably nasal spray sumatriptan. 8 In case reports, IV verapamil seems effective for acute hemiplegic migraine.…”

mentioning

confidence: 99%

Child Neurology: Migraine with aura in children

Gelfand¹,

Fullerton²,

Goadsby³

2010

Neurology

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The differential diagnosis for an acute hemiparesis in a child includes stroke, Todd paralysis, and hemiplegic migraine. In the context of an illustrative case, this review highlights the differences in clinical presentation among these entities and an approach to the diagnostic workup. Migraine with aura in children is reviewed, including migraine equivalents such as abdominal migraine and the particular presentation of hemiplegic migraine. An approach to the prophylactic and acute treatment for children with migraine with aura is offered. Neurology ® 2010;75:e16 -e19 CASE: PART 1 A 14-year-old boy with Crohn disease was admitted for a presumed flare. On the second hospital day, his abdominal pain acutely increased. Shortly thereafter, he experienced tingling starting in his shoulder and spreading over his left hemibody over 10 seconds. This was accompanied by 7/10 pounding left-sided head pain. Several minutes later, the tingling gave way to diminished sensation and weakness on the left. These symptoms persisted into the next morning, at which time a neurologic consultation was requested. Now 20 hours into the attack, he had 5/10 pounding head pain. Neurologic examination revealed a left hemiparesis in a pyramidal distribution, with face and arm affected more than leg. Sensation was also diminished over the left face and hemibody. Reflexes were normal and there was no neglect. Complete blood count, electrolytes, erythrocyte sedimentation rate, liver function tests, lactate, amylase, and lipase were normal.

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mentioning

confidence: 99%

Child Neurology: Migraine with aura in children

Gelfand¹,

Fullerton²,

Goadsby³

2010

Neurology

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“…Numerous triptans have been studied in adolescent migraine, most with positive results. Triptans most recently studied include almotriptan [ 23 ] and zolmitriptan nasal spray [ 24 ] and tablet [ 25 ]. Others have been studied; however, the short duration of headache in adolescents, high placebo response rate, and few randomized controlled trials have resulted in limited compelling data and no formal approval for use in those younger than 18 years.…”

Section: Abortive Treatmentmentioning

confidence: 97%

Adolescent issues in migraine: A focus on menstrual migraine

Lay¹,

Broner

2008

Current Science Inc

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Migraine commonly affects adolescents, and menstrual migraine often begins in young girls. If undiagnosed or ineffectively treated, migraine can lead to disability, school absenteeism, emotional or social difficulties, and chronification of headache. Thus, recognizing and accurately diagnosing migraine and menstrual migraine, developing effective treatment strategies (both pharmacologic and nonpharmacologic), and educating both the adolescent and her parents are important in order to minimize the potential early disability of this disorder and limit the otherwise likely progression of migraine to a disabling disorder of adulthood.

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“…This was based on a randomized, doubleblind, placebo controlled trial of almotriptan in 866 adolescents (age 12-17), which found a 2-h pain-relief rate that was significantly higher for all doses of almotriptan -6.25 mg (71.8%), 12.5 mg (72.9%) and 25 mg (66.7%) compared with placebo (55.3%) [54].…”

Section: Acute Treatmentmentioning

confidence: 99%