Recent developments in pediatric headache

Hershey, Andrew D.

doi:10.1097/wco.0b013e3283391888

Cited by 19 publications

(15 citation statements)

References 69 publications

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“…Migraine is considered to be a heterogeneous disorder: attacks may vary in terms of the intensity of pain, duration, pattern of associated features and frequency (4,5). The overall prevalence ranges from 3% in children aged 3-7 years to 23% in teenagers (6); however, epidemiological studies are challenging.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological and clinical features of migraine in the pediatric population of Northern Italy

et al. 2015

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We describe the characteristics of pediatric migraine based on the ICHD-II criteria, showing a likely significant loss of diagnoses using the ICHD-III beta. The incidence of migraine increases with age. MO occurs more commonly and shows more frequent attacks and a higher prevalence of associated symptoms, in particular osmophobia. Although males are prevalent in the entire sample, the proportion of females is higher among patients with MA in all of the age groups. Phenotype and sexual prevalence of migraine acquire adult characteristics and become more frequent in females from the onset of puberty.

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Section: Introductionmentioning

confidence: 99%

Epidemiological and clinical features of migraine in the pediatric population of Northern Italy

et al. 2015

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“…29 These neurophysiological findings indicate that migraine is associated with cortical dysfunction. 13,14 It seems that the cerebral cortex serves a primary role in the cascade of migraine attacks. 15 …”

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confidence: 99%

Altered Cortical Activation in Adolescents With Acute Migraine: A Magnetoencephalography Study

Xiang

deGrauw

Korostenskaja

et al. 2013

The Journal of Pain

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To quantitatively assess cortical dysfunction in pediatric migraine, 31 adolescents with acute migraine and age- and gender-matched controls were studied using a magnetoencephalography (MEG) system at a sampling rate of 6,000 Hz. Neuromagnetic brain activation was elicited by a finger-tapping task. The spectral and spatial signatures of magnetoencephalography data in 5 to 2,884 Hz were analyzed using Morlet wavelet and beamformers. Compared with controls, 31 migraine subjects during their headache attack phases (ictal) showed significantly prolonged latencies of neuromagnetic activation in 5 to 30 Hz, increased spectral power in 100 to 200 Hz, and a higher likelihood of neuromagnetic activation in the supplementary motor area, the occipital and ipsilateral sensorimotor cortices, in 2,200 to 2,800 Hz. Of the 31 migraine subjects, 16 migraine subjects during their headache-free phases (interictal) showed that there were no significant differences between interictal and control MEG data except that interictal spectral power in 100 to 200 Hz was significantly decreased. The results demonstrated that migraine subjects had significantly aberrant ictal brain activation, which can normalize interictally. The spread of abnormal ictal brain activation in both low- and high-frequency ranges triggered by movements may play a key role in the cascade of migraine attacks. Perspective This is the first study focusing on the spectral and spatial signatures of cortical dysfunction in adolescents with migraine using MEG signals in a frequency range of 5 to 2,884 Hz. This analyzing aberrant brain activation may be important for developing new therapeutic interventions for migraine in the future.

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“…[1][2][3] It is well known that of the primary headache disorders, pediatric migraine has the greatest effect on a child's quality of life. It has known effects on school performance and attendance, socialization, and family function.…”

Section: Introductionmentioning

confidence: 99%

“…It has known effects on school performance and attendance, socialization, and family function. 1,4,5 Early recognition of migraine is important to ensure appropriate management. Unfortunately, waiting times to see a pediatric neurologist in Canada average between 8 and 12 months (National Pediatric Neurology Survey Data, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8] In spite of these adjustments, the diagnosis of pediatric migraine remains difficult as children may not be able to describe their headache features in a clinical setting. 1,[9][10][11] The diagnosis of migraine specifically depends on a child's or a parent's ability to recall and communicate his or her symptoms at the time of clinical assessment. 11 Furthermore, a sizable number of children have migrainous headaches lasting <1 hour, which based on current ICHD-II criteria could lead to under recognition of pediatric migraine.…”

Section: Introductionmentioning

confidence: 99%

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The McMaster Pediatric Migraine Questionnaire: A Prospective Validation Study

Whitney

Borys

Callen

et al. 2015

Pediatric Neurology

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Recent developments in pediatric headache

Abstract: Our understanding of pediatric headache is improving with increased recognition of the characteristics and associated symptomology. This should further guide the individualized treatment approaches for improved outcome and reduction of progression into adulthood.

Cited by 19 publications

References 69 publications

Epidemiological and clinical features of migraine in the pediatric population of Northern Italy

Epidemiological and clinical features of migraine in the pediatric population of Northern Italy

Altered Cortical Activation in Adolescents With Acute Migraine: A Magnetoencephalography Study

The McMaster Pediatric Migraine Questionnaire: A Prospective Validation Study

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