2016
DOI: 10.4103/0366-6999.173432
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Efficacy and Safety of “URSA Complex” in Subjects with Physical Fatigue

Abstract: Background:Fatigue is a common symptom both in diseases status and in healthy subjects. Various supplements and nutraceuticals for relieving of fatigue have been used. However, there are a few studies to evaluate the efficacy and the safety of the drug for fatigue alleviation, we conducted using URSA Complex to evaluate the efficacy on physical fatigue via score changes in the checklist individual strength (CIS).Methods:The study was designed as a multicenter, randomized, double-blind, placebo-controlled trial… Show more

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(11 citation statements)
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“…All 8 studies ( Gal et al., 1996 ; Engels et al., 1996 ; Engels et al., 2001 ; Engels et al., 2003 ; Hartz et al., 2004 ; Hyeong-Geug et al., 2013 ; Kim et al., 2016 ; Lee et al., 2016 ) were RCTs, which involved a total of 678 participants, and the sample size ranged from 19 to 218. Five RCTs ( Gal et al., 1996 ; Hartz et al., 2004 ; Hyeong-Geug et al., 2013 ; Kim et al., 2016 ; Lee et al., 2016 ) involved 615 participants with CFS. The diagnostic criteria of patients with CFS were based on ECUCF.…”
Section: Resultsmentioning
confidence: 99%
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“…All 8 studies ( Gal et al., 1996 ; Engels et al., 1996 ; Engels et al., 2001 ; Engels et al., 2003 ; Hartz et al., 2004 ; Hyeong-Geug et al., 2013 ; Kim et al., 2016 ; Lee et al., 2016 ) were RCTs, which involved a total of 678 participants, and the sample size ranged from 19 to 218. Five RCTs ( Gal et al., 1996 ; Hartz et al., 2004 ; Hyeong-Geug et al., 2013 ; Kim et al., 2016 ; Lee et al., 2016 ) involved 615 participants with CFS. The diagnostic criteria of patients with CFS were based on ECUCF.…”
Section: Resultsmentioning
confidence: 99%
“…The rest of 3 RCTs ( Engels et al., 1996 ; Engels et al., 2001 ; Engels et al., 2003 ) involved 63 healthy adults after exercise. They were published from 1996 to 2016 and conducted in America (n = 4) ( Engels et al., 1996 ; Engels et al., 2001 ; Engels et al., 2003 ; Hartz et al., 2004 ), South Korea (n = 3) ( Hyeong-Geug et al., 2013 ; Kim et al., 2016 ; Lee et al., 2016 ), and France (n = 1) ( Gal et al., 1996 ). The duration of treatment ranged from 4 to 8 weeks.…”
Section: Resultsmentioning
confidence: 99%
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