Efficacy and safety of treating T4 oral cavity tumors with primary chemoradiotherapy

Cohen, Ezra E.W.; Baru, Joshua; Huo, Dezheng; Haraf, Daniel J.; Crowley, Maureen; Witt, Mary Ellyn; Blair, Elizabeth A.; Weichselbaum, Ralph R.; Rosen, Fred; Vokes, Everett E.; Stenson, Kerstin

doi:10.1002/hed.21062

Cited by 56 publications

(41 citation statements)

References 26 publications

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“…34 In a subgroup of 39 patients with T4 disease, local control was obtained in 75% and ORN occurred in 7 patients. 35 Of the 10 patients with bone invasion, 3 cases (30%) of ORN of the mandible developed at 2 to 3 years posttreatment. In all 3 cases, the patients underwent successful surgical debride- ment and reconstruction.…”

Section: Discussionmentioning

confidence: 99%

Concurrent Chemotherapy and Intensity-Modulated Radiotherapy for Organ Preservation of Locoregionally Advanced Oral Cavity Cancer

Pederson

Salama²,

Witt³

et al. 2011

American Journal of Clinical Oncology

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Section: Discussionmentioning

confidence: 99%

Concurrent Chemotherapy and Intensity-Modulated Radiotherapy for Organ Preservation of Locoregionally Advanced Oral Cavity Cancer

Pederson

Salama²,

Witt³

et al. 2011

American Journal of Clinical Oncology

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“…Rates of locoregional control, survival and complications are comparable to those associated with primary surgical management and postoperative radiotherapy [80]. Another reason to choose chemoradiotherapy as a primary treatment may be “functional irresectability”, for example, to avoid total glossectomy.…”

Section: Principles Of Oral Cavity Cancer Managementmentioning

confidence: 99%

Contemporary management of cancer of the oral cavity

Genden

Ferlito²,

Silver

et al. 2010

Eur Arch Otorhinolaryngol

110

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Oral cancer represents a common entity comprising a third of all head and neck malignant tumors. The options for curative treatment of oral cavity cancer have not changed significantly in the last three decades; however, the work up, the approach to surveillance, and the options for reconstruction have evolved significantly. Because of the profound functional and cosmetic importance of the oral cavity, management of oral cavity cancers requires a thorough understanding of disease progression, approaches to management and options for reconstruction. The purpose of this review is to discuss the most current management options for oral cavity cancers.

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“…12 At this stage, the 5 year survival rate is close to 50%, whether treatment is surgical resection (47% survival) 13 or chemotherapy (56% survival). 14 For this reason, detection of bone tissue invasion significantly improves patient prognosis.…”

Section: Introductionmentioning

confidence: 99%

Accuracy of imaging methods for detection of bone tissue invasion in patients with oral squamous cell carcinoma

Uribe

Rojas²,

Rosas³

2013

Dentomaxillofacial Radiology

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The objective of this review is to evaluate the diagnostic accuracy of imaging methods for detection of mandibular bone tissue invasion by squamous cell carcinoma (SCC). A systematic review was carried out of studies in MEDLINE, SciELO and ScienceDirect, published between 1960 and, in English, Spanish or German, which compared detection of mandibular bone tissue invasion via different imaging tests against a histopathology reference standard. Sensitivity and specificity data were extracted from each study. The outcome measure was diagnostic accuracy. We found 338 articles, of which 5 fulfilled the inclusion criteria. Tests included were: CT (four articles), MRI (four articles), panoramic radiography (one article), positron emission tomography (PET)/CT (one article) and cone beam CT (CBCT) (one article). The quality of articles was low to moderate and the evidence showed that all tests have a high diagnostic accuracy for detection of mandibular bone tissue invasion by SCC, with sensitivity values of 94% (MRI), 91% (CBCT), 83% (CT) and 55% (panoramic radiography), and specificity values of 100% (CT, MRI, CBCT), 97% (PET/CT) and 91.7% (panoramic radiography). Available evidence is scarce and of only low to moderate quality. However, it is consistently shown that current imaging methods give a moderate to high diagnostic accuracy for the detection of mandibular bone tissue invasion by SCC. Recommendations are given for improving the quality of future reports, in particular provision of a detailed description of the patients' conditions, the imaging instrument and both imaging and histopathological invasion criteria.

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Efficacy and safety of treating T4 oral cavity tumors with primary chemoradiotherapy

Cited by 56 publications

References 26 publications

Concurrent Chemotherapy and Intensity-Modulated Radiotherapy for Organ Preservation of Locoregionally Advanced Oral Cavity Cancer

Concurrent Chemotherapy and Intensity-Modulated Radiotherapy for Organ Preservation of Locoregionally Advanced Oral Cavity Cancer

Contemporary management of cancer of the oral cavity

Accuracy of imaging methods for detection of bone tissue invasion in patients with oral squamous cell carcinoma

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