Contemporary management of cancer of the oral cavity

Genden, Eric M.; Ferlito, Alfio; Silver, Carl E.; Takes, Robert P.; Suárez, Carlos; Owen, Randall P.; Haigentz, Missak; Stoeckli, Sandro J.; Shaha, Ashok R.; Rapidis, Alexander D.; Rodrigo, Juan P.; Rinaldo, Alessandra

doi:10.1007/s00405-010-1206-2

Cited by 116 publications

(81 citation statements)

References 123 publications

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“…5 For malignant tumours such as SCC, rapid growth may occur even though there are no previous clinical signs. 6 For this reason, clinical examination must be complemented by radiological examination 7 for the assessment of size, thickness and depth of the tumour 8 as well as the degree of bone tissue invasion. [9][10][11] This bone tissue invasion detection, cortical or medullary, is indicative of a T4 tumour stage.…”

Section: Introductionmentioning

confidence: 99%

Accuracy of imaging methods for detection of bone tissue invasion in patients with oral squamous cell carcinoma

Uribe

Rojas²,

Rosas³

2013

Dentomaxillofacial Radiology

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The objective of this review is to evaluate the diagnostic accuracy of imaging methods for detection of mandibular bone tissue invasion by squamous cell carcinoma (SCC). A systematic review was carried out of studies in MEDLINE, SciELO and ScienceDirect, published between 1960 and, in English, Spanish or German, which compared detection of mandibular bone tissue invasion via different imaging tests against a histopathology reference standard. Sensitivity and specificity data were extracted from each study. The outcome measure was diagnostic accuracy. We found 338 articles, of which 5 fulfilled the inclusion criteria. Tests included were: CT (four articles), MRI (four articles), panoramic radiography (one article), positron emission tomography (PET)/CT (one article) and cone beam CT (CBCT) (one article). The quality of articles was low to moderate and the evidence showed that all tests have a high diagnostic accuracy for detection of mandibular bone tissue invasion by SCC, with sensitivity values of 94% (MRI), 91% (CBCT), 83% (CT) and 55% (panoramic radiography), and specificity values of 100% (CT, MRI, CBCT), 97% (PET/CT) and 91.7% (panoramic radiography). Available evidence is scarce and of only low to moderate quality. However, it is consistently shown that current imaging methods give a moderate to high diagnostic accuracy for the detection of mandibular bone tissue invasion by SCC. Recommendations are given for improving the quality of future reports, in particular provision of a detailed description of the patients' conditions, the imaging instrument and both imaging and histopathological invasion criteria.

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Section: Introductionmentioning

confidence: 99%

Accuracy of imaging methods for detection of bone tissue invasion in patients with oral squamous cell carcinoma

Uribe

Rojas²,

Rosas³

2013

Dentomaxillofacial Radiology

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“…The standard method for oral cancer screening has long been conventional oral examination and palpation. Visual inspection of the oral cavity is performed under normal white light illumination, followed by palpation of suspicious lesions [34]. The gold standard diagnostic test for oral mucosal lesions remains tissue biopsy and histopathological examination.…”

Section: Diagnosismentioning

confidence: 99%

Oral Cavity Cancer: Risk Factors, Pathology, and Management

Ernani

Saba²

2015

Oncology

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Oral cavity cancers are predominantly squamous cell carcinomas, which arise from premalignant lesions through a multistep carcinogenesis process. Tobacco and alcohol are the major etiologic factors, although human papillomavirus has also recently been implicated as a causative agent. The possibility of a second primary malignancy should be considered during the diagnostic evaluation of head and neck cancers, as well as during the posttreatment surveillance phase. The goals of treatment are not only to improve survival outcomes but also to preserve organ function. These cancers are generally treated with a combination of surgery, radiation therapy, and chemotherapy. A multidisciplinary approach, involving surgeons, medical oncologists, and radiation oncologists, as well as dentists, dietitians, and rehabilitation therapists, is generally required for optimal treatment planning and management of patients with head and neck cancer.

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“…The risk of recurrence or development of a new primary tumor warrant long-term follow-up for all patients treated for cancer of the oral cavity, and regular monitoring is indicated for a minimum 5 years. Finally, high-risk patients should be monitored more frequently than low-risk ones [1,8,37]. We continue doing clinical follow-up of the subjects of the research, as well as other hospital patients, and until the present moment only two cases recurred.…”

Section: Discussionmentioning

confidence: 97%

“…The options for curative treatment of oral cavity squamous cell carcinoma have not changed significantly in the last decades [1], and include surgery, radiation therapy, chemotherapy, or combinations of these modalities [2]. The choice of treatment depends mainly on the site and size of the primary lesion, in addition to the patient's age and general health [3].…”

Section: Introductionmentioning

confidence: 99%