Efficacy and safety of traditional Chinese herbal formula combined with western medicine for gastroesophageal reflux disease

Lin, Wuhong; Huang, Guihua; Liu, Xirong; Hua-sheng, Lin; Zhou, Haoming; Feng, Chunbing; Wang, Tingshuai; Liang, Renjiu

doi:10.1097/md.0000000000022454

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…현재까지 역류성 식도염에 대해 다양한 한의학 적 연구가 있었다. 역류성 식도염에 대한 한-양약 의 병용 치료 효과에 대한 메타분석 논문 11 , 소시호 탕가미를 이용한 무작위 대조 임상시험 논문 등이 있었으며 12 , 가미양격산화탕 8 , 오패산합작약감초탕 가감방 9 등의 약물을 이용한 치험례들이 꾸준히 보 고되었다.…”

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A Case Report of Reflux Esophagitis After Gastrectomy due to Gastric Ulcer

Park¹,

Moon²,

Jeon³

et al. 2022

J Int Korean Med

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Objectives: The purpose of this study was to report the effectiveness of Korean medicine in the treatment of reflux esophagitis.Methods: A 62-year-old male patient had reflux esophagitis that occurred one year after a proximal gastrectomy for gastric ulcer in 2020. The patient underwent drug treatment in 2021 and inpatient treatment in 2022 at Mokpo Hankook Hospital, but he did not improve. We treated him with Korean medical treatments, including herbal medicines (Pyungjingunbi-tang-gami), acupuncture, and moxibustion. His symptom severity was assessed with a daily visual analog scale (VAS) for heartburn, upper abdomen pain, and acid reflux.Results: After treatment, the patient's symptoms were improved. The severity of heartburn and acid reflux was reduced from VAS 7 to VAS 1, and his upper abdomen pain was improved from VAS 6 to VAS 1. The symptom frequency was also reduced.Conclusion: Korean medicine treatment could be an effective and quick treatment for reflux esophagitis.

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A Case Report of Reflux Esophagitis After Gastrectomy due to Gastric Ulcer

Park¹,

Moon²,

Jeon³

et al. 2022

J Int Korean Med

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Mechanisms of Chinese Medicine in Gastroesophageal Reflux Disease Treatment: Data Mining and Systematic Pharmacology Study

Chen

Zhou

et al. 2022

Chin. J. Integr. Med.

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Therapeutic effect of Wendan Decoction combined with mosapride on gastroesophageal reflux disease after esophageal cancer surgery

Zhang,

2024

World J Clin Cases

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BACKGROUND Gastroesophageal reflux disease (GERD) is a common complication of esophageal cancer surgery that can affect quality of life and increase the risk of esophageal stricture and anastomotic leakage. Wendan Decoction (WDD) is a traditional Chinese herbal formula used to treat various gastrointestinal disorders, such as gastritis, functional dyspepsia, and irritable bowel syndrome. Mosapride, a prokinetic agent, functions as a selective 5-hydroxytryptamine 4 agonist, enhancing gastrointestinal motility. AIM To evaluate the therapeutic effects of WDD combined with mosapride on GERD after esophageal cancer surgery. METHODS Eighty patients with GERD were randomly divided into treatment (receiving WDD combined with mosapride) and control (receiving mosapride alone) groups. The treatment was conducted from January 2021 to January 2023. The primary outcome was improved GERD symptoms as measured using the reflux disease questionnaire (RDQ). The secondary outcomes were improved esophageal motility (measured using esophageal manometry), gastric emptying (measured using gastric scintigraphy), and quality of life [measured via the Short Form-36 (SF-36) Health Survey]. RESULTS The treatment group showed a notably reduced RDQ score and improved esophageal motility parameters, such as lower esophageal sphincter pressure, peristaltic amplitude, and peristaltic velocity compared to the control group. The treatment group showed significantly higher gastric emptying rates and SF-36 scores (in both physical and mental domains) compared to the control group. No serious adverse effects were observed in either group. CONCLUSION WDD combined with mosapride is an effective and safe therapy for GERD after esophageal cancer surgery. It can improve GERD symptoms, esophageal motility, gastric emptying, and the quality of life of patients. Further studies with larger sample sizes and longer follow-up periods are required to confirm these findings.

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Efficacy and safety of traditional Chinese herbal formula combined with western medicine for gastroesophageal reflux disease

Cited by 3 publications

References 15 publications

A Case Report of Reflux Esophagitis After Gastrectomy due to Gastric Ulcer

A Case Report of Reflux Esophagitis After Gastrectomy due to Gastric Ulcer

Mechanisms of Chinese Medicine in Gastroesophageal Reflux Disease Treatment: Data Mining and Systematic Pharmacology Study

Therapeutic effect of Wendan Decoction combined with mosapride on gastroesophageal reflux disease after esophageal cancer surgery

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