Efficacy and safety of the compound Chinese medicine SaiLuoTong in vascular dementia: A randomized clinical trial

Abstract

IntroductionNo licensed medications are available to treat vascular dementia (VaD).MethodsPatients were randomly assigned to experimental groups (SaiLuoTong [SLT] 360 or 240 mg for groups A and B for 52 weeks, respectively) or placebo group (SLT 360 mg and 240 mg for group C only from weeks 27 to 52, respectively).ResultsThree hundred twenty-five patients were included in final analysis. At week 26, the difference in VaD Assessment Scale–cognitive subscale scores was 2.67 (95% confidence interval, 1.54 to 3.81) for groups A versus C, and 2.48 (1.34 to 3.62) for groups B versus C (both P < .0001). However, at week 52, no difference was observed among the groups on the VaD Assessment Scale–cognitive subscale (P = .062) because of the emerging efficacy of SLT in placebo beginning at week 27.DiscussionThis study suggests that SLT is effective for treatment of VaD, and this compound Chinese medicine may represent a better choice to treat VaD.

Endothelium-Independent Vasodilatory Effect of Sailuotong (SLT) on Rat Isolated Tail Artery

“…The SLT formula consists of standard extracts of specific dosages of Panax ginseng C. A. Meyer (ginseng), Gingko biloba L. (ginkgo), and Crocus sativus L. (saffron). The chemical profile and ratio of the three herbal extracts had been determined and studied in detail previously [ 10 , 11 ]. The cognitive enhancing effect of SLT has been demonstrated in both preclinical and clinical studies.…”

Involvement of 8-O-acetylharpagide for Ajuga taiwanensis mediated suppression of senescent phenotypes in human dermal fibroblasts

“…However, chemical or growth factor based anti-aging compounds may raise unexpected side effects 25 . On the other hand, the safety of herbal medicine used for designing of cosmetic products is highly acceptable 26,27 . In this study, high passage of HDFs exhibited delayed cell growth rate accompanied by increase of p53 and SA-β-gal.…”

New Insights for Cellular and Molecular Mechanisms of Aging and Aging-Related Diseases: Herbal Medicine as Potential Therapeutic Approach

“…Through in vivo and in vitro studies, various components of herbal medicine have been found to possess the ability to intervene in aging-related diseases by activating telomerase, increasing antioxidant capacity, reducing apoptosis and anti-inflammatory activities, and regulating aging-related pathways and exosomes. We also summarized the clinical randomized controlled trials (RCTs) of herbal medicine in the treatment of aging-related diseases ( Table 3) [240][241][242][243][244][245][246][247][248][249][250]. These trials found that herbal medicine displays certain clinical efficacy in the treatment of agerelated diseases such as type 2 diabetes, vascular dementia, AD, and atherosclerosis.…”

“…A few clinical studies on AMD exist, but this disorder is considered to be related to the special technique used for intravitreal administration when treating macular lesions. Of note, as shown in Table 3, there are some adverse reactions in the clinical use of herbal medicines, including gastrointestinal discomfort, dry mouth, and abnormal alanine aminotransferase [245][246][247]250]. Experimental studies had also found that there was a dose-response curve characterized by stimulation at a low dose and inhibition at a high dose.…”